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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MLXIPL
Z-value: 0.86
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Transcription factors associated with MLXIPL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLXIPL | hg19_v2_chr7_-_73038867_73038878, hg19_v2_chr7_-_73038822_73038862 | 0.57 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLXIPL
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21452804 | 1.39 |
ENST00000269217.6 |
LAMA3 |
laminin, alpha 3 |
| chr1_+_44401479 | 1.08 |
ENST00000438616.3 |
ARTN |
artemin |
| chr16_+_68679193 | 1.01 |
ENST00000581171.1 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
| chr19_-_36004543 | 0.93 |
ENST00000339686.3 ENST00000447113.2 ENST00000440396.1 |
DMKN |
dermokine |
| chr18_+_21452964 | 0.87 |
ENST00000587184.1 |
LAMA3 |
laminin, alpha 3 |
| chr17_-_3599492 | 0.82 |
ENST00000435558.1 ENST00000345901.3 |
P2RX5 |
purinergic receptor P2X, ligand-gated ion channel, 5 |
| chr22_-_20255212 | 0.82 |
ENST00000416372.1 |
RTN4R |
reticulon 4 receptor |
| chr18_-_28681950 | 0.74 |
ENST00000251081.6 |
DSC2 |
desmocollin 2 |
| chr18_+_21529811 | 0.72 |
ENST00000588004.1 |
LAMA3 |
laminin, alpha 3 |
| chr16_+_66914264 | 0.68 |
ENST00000311765.2 ENST00000568869.1 ENST00000561704.1 ENST00000568398.1 ENST00000566776.1 |
PDP2 |
pyruvate dehyrogenase phosphatase catalytic subunit 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.7 | 2.0 | GO:0060901 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 0.0 | 1.7 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.2 | 1.3 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.2 | 1.3 | GO:0015820 | leucine transport(GO:0015820) |
| 0.1 | 1.2 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.1 | 1.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.2 | 1.1 | GO:0097021 | lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.1 | 1.1 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.1 | 1.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 2.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 2.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 1.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 1.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 1.1 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.9 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.9 | GO:0030673 | axolemma(GO:0030673) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 1.2 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 1.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.3 | 1.0 | GO:0038131 | neuregulin receptor activity(GO:0038131) |
| 0.1 | 0.9 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 0.9 | GO:0031014 | troponin T binding(GO:0031014) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 2.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.1 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.1 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 1.1 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.0 | 0.9 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |