ISMARA results: MLX_USF2_USF1

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for MLX_USF2_USF1_PAX2

Z-value: 1.57

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Transcription factors associated with MLX_USF2_USF1_PAX2

Gene Symbol	Gene ID	Gene Info
MLX Ensembl NCBI GeneCards UniProt	ENSG00000108788.7	MLX
USF2 Ensembl NCBI GeneCards UniProt	ENSG00000105698.11	USF2
USF1 Ensembl NCBI GeneCards UniProt	ENSG00000158773.10	USF1
PAX2 Ensembl NCBI GeneCards UniProt	ENSG00000075891.17	PAX2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
USF1	hg19_v2_chr1_-_161014731_161014788, hg19_v2_chr1_-_161015752_161015778	-0.55	1.5e-01	Click!
USF2	hg19_v2_chr19_+_35759968_35760042	0.38	3.6e-01	Click!
MLX	hg19_v2_chr17_+_40719073_40719092	-0.27	5.1e-01	Click!
PAX2	hg19_v2_chr10_+_102505468_102505546	-0.16	7.0e-01	Click!

Activity profile of MLX_USF2_USF1_PAX2 motif

Sorted Z-values of MLX_USF2_USF1_PAX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr1_+_183605200	3.85	ENST00000304685.4	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr19_+_49458107	3.45	ENST00000539787.1 ENST00000345358.7 ENST00000391871.3 ENST00000415969.2 ENST00000354470.3 ENST00000506183.1 ENST00000293288.8	BAX	BCL2-associated X protein
chr15_+_41913690	3.12	ENST00000563576.1	MGA	MGA, MAX dimerization protein
chr9_-_79307096	2.99	ENST00000376717.2 ENST00000223609.6 ENST00000443509.2	PRUNE2	prune homolog 2 (Drosophila)
chr1_+_221051699	2.98	ENST00000366903.6	HLX	H2.0-like homeobox
chr15_+_33022885	2.74	ENST00000322805.4	GREM1	gremlin 1, DAN family BMP antagonist
chr5_-_172198190	2.64	ENST00000239223.3	DUSP1	dual specificity phosphatase 1
chr12_-_63328817	2.60	ENST00000228705.6	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_-_241520525	2.45	ENST00000366565.1	RGS7	regulator of G-protein signaling 7
chr12_+_90102729	2.40	ENST00000605386.1	LINC00936	long intergenic non-protein coding RNA 936

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	6.2	GO:0060155	platelet dense granule organization(GO:0060155)
1.0	5.9	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.4	5.5	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.1	5.3	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.5	5.2	GO:0015889	cobalamin transport(GO:0015889)
1.2	4.8	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	3.1	GO:0051865	protein autoubiquitination(GO:0051865)
0.3	2.9	GO:1990253	cellular response to leucine starvation(GO:1990253)
0.9	2.7	GO:1900158	negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2	2.7	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)

Showing 1 to 10 of 367 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.5	GO:0031083	BLOC-1 complex(GO:0031083)
0.1	5.9	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1	5.2	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	4.5	GO:0043202	lysosomal lumen(GO:0043202)
0.0	3.9	GO:0005901	caveola(GO:0005901)
0.2	3.5	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.5	3.3	GO:1990131	Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	3.0	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	2.9	GO:0016235	aggresome(GO:0016235)
0.0	2.7	GO:0031902	late endosome membrane(GO:0031902)

Showing 1 to 10 of 163 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.1	GO:0005507	copper ion binding(GO:0005507)
0.2	8.6	GO:0050699	WW domain binding(GO:0050699)
0.5	5.1	GO:0031419	cobalamin binding(GO:0031419)
0.3	4.8	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	4.3	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.1	4.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.6	3.9	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	3.9	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.1	3.6	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.1	3.6	GO:0042169	SH2 domain binding(GO:0042169)

Showing 1 to 10 of 207 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	4.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	4.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	4.0	PID MYC PATHWAY	C-MYC pathway
0.0	3.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	3.5	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	3.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	2.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	2.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.5	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta

Showing 1 to 10 of 54 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.6	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	7.0	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	3.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	3.4	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	3.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	2.9	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	2.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	2.5	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	2.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	2.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins

Showing 1 to 10 of 66 entries

Results for MLX_USF2_USF1_PAX2

Z-value: 1.57

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Activity-expression correlation:

Activity profile of MLX_USF2_USF1_PAX2 motif

Sorted Z-values of MLX_USF2_USF1_PAX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: