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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MXI1_MYC_MYCN
Z-value: 4.31
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Transcription factors associated with MXI1_MYC_MYCN
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYC | hg19_v2_chr8_+_128748308_128748330, hg19_v2_chr8_+_128748466_128748487 | 0.81 | 1.4e-02 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | 0.75 | 3.3e-02 | Click! |
| MXI1 | hg19_v2_chr10_+_111967345_111967442, hg19_v2_chr10_+_111985713_111985774 | -0.12 | 7.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_40390930 | 9.16 |
ENST00000333407.6 |
FAM83F |
family with sequence similarity 83, member F |
| chr16_+_68679193 | 5.70 |
ENST00000581171.1 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
| chr8_-_75233563 | 5.62 |
ENST00000342232.4 |
JPH1 |
junctophilin 1 |
| chr8_+_95653427 | 5.29 |
ENST00000454170.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr8_+_95653373 | 5.28 |
ENST00000358397.5 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr8_+_95653302 | 5.25 |
ENST00000423620.2 ENST00000433389.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr11_+_72929402 | 5.06 |
ENST00000393596.2 |
P2RY2 |
purinergic receptor P2Y, G-protein coupled, 2 |
| chr11_+_72929319 | 5.05 |
ENST00000393597.2 ENST00000311131.2 |
P2RY2 |
purinergic receptor P2Y, G-protein coupled, 2 |
| chr17_-_17109579 | 4.97 |
ENST00000321560.3 |
PLD6 |
phospholipase D family, member 6 |
| chr17_+_55163075 | 4.93 |
ENST00000571629.1 ENST00000570423.1 ENST00000575186.1 ENST00000573085.1 ENST00000572814.1 |
AKAP1 |
A kinase (PRKA) anchor protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 17.7 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 3.5 | 10.5 | GO:0032773 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 0.8 | 10.1 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.8 | 10.0 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 1.3 | 9.3 | GO:0089712 | L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712) |
| 0.1 | 8.5 | GO:0045815 | positive regulation of gene expression, epigenetic(GO:0045815) |
| 0.6 | 8.2 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.2 | 7.8 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.8 | 7.7 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 54.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 16.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 15.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 13.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.6 | 12.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 10.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 10.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.3 | 9.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.2 | 9.3 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.5 | 8.7 | GO:0034709 | methylosome(GO:0034709) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.5 | 11.0 | GO:0001614 | purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) |
| 0.0 | 10.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.3 | 9.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 8.6 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 8.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.9 | 8.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 8.4 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 7.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.3 | 7.7 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 8.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 5.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 4.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 4.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 4.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 3.7 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.3 | 11.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 10.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 9.9 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.4 | 9.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.5 | 9.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 8.9 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.1 | 8.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 8.1 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 7.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |