Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MYB
Z-value: 1.77
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Transcription factors associated with MYB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYB | hg19_v2_chr6_+_135502501_135502652 | -0.51 | 2.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_31608054 | 1.30 |
ENST00000320985.10 ENST00000361642.5 ENST00000560721.2 ENST00000558440.1 ENST00000424869.1 ENST00000542815.3 |
ZEB1 |
zinc finger E-box binding homeobox 1 |
| chr14_+_29236269 | 1.15 |
ENST00000313071.4 |
FOXG1 |
forkhead box G1 |
| chr7_-_127032363 | 0.84 |
ENST00000393312.1 |
ZNF800 |
zinc finger protein 800 |
| chr5_+_151151471 | 0.61 |
ENST00000394123.3 ENST00000543466.1 |
G3BP1 |
GTPase activating protein (SH3 domain) binding protein 1 |
| chr2_-_190044480 | 0.58 |
ENST00000374866.3 |
COL5A2 |
collagen, type V, alpha 2 |
| chr21_+_47531328 | 0.56 |
ENST00000409416.1 ENST00000397763.1 |
COL6A2 |
collagen, type VI, alpha 2 |
| chr19_-_14530143 | 0.56 |
ENST00000242776.4 |
DDX39A |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A |
| chr2_-_230579185 | 0.56 |
ENST00000341772.4 |
DNER |
delta/notch-like EGF repeat containing |
| chr17_+_7482785 | 0.54 |
ENST00000250092.6 ENST00000380498.6 ENST00000584502.1 |
CD68 |
CD68 molecule |
| chr1_+_162602244 | 0.53 |
ENST00000367922.3 ENST00000367921.3 |
DDR2 |
discoidin domain receptor tyrosine kinase 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.0 | 1.3 | GO:0032392 | DNA geometric change(GO:0032392) |
| 0.1 | 1.2 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.0 | 1.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 0.9 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 0.8 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.0 | 0.8 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 0.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 0.7 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.1 | 0.7 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.4 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.0 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.9 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.7 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 0.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.3 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 1.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.3 | 0.9 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.2 | 0.7 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.0 | 0.7 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 0.6 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 0.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 0.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.5 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.8 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 0.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 1.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.8 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.6 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.6 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.5 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.0 | 0.5 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |