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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for NFIX_NFIB
Z-value: 1.80
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Transcription factors associated with NFIX_NFIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIB | hg19_v2_chr9_-_14314066_14314075, hg19_v2_chr9_-_14314566_14314618, hg19_v2_chr9_-_14314518_14314556, hg19_v2_chr9_-_14313641_14313666 | -0.50 | 2.0e-01 | Click! |
| NFIX | hg19_v2_chr19_+_13106383_13106423, hg19_v2_chr19_+_13135731_13135787, hg19_v2_chr19_+_13134772_13134846 | 0.26 | 5.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIX_NFIB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_189840223 | 1.27 |
ENST00000427335.2 |
LEPREL1 |
leprecan-like 1 |
| chr22_+_24990746 | 1.07 |
ENST00000456869.1 ENST00000411974.1 |
GGT1 |
gamma-glutamyltransferase 1 |
| chr14_+_96722539 | 0.94 |
ENST00000553356.1 |
BDKRB1 |
bradykinin receptor B1 |
| chr5_+_167181917 | 0.92 |
ENST00000519204.1 |
TENM2 |
teneurin transmembrane protein 2 |
| chr2_-_46385 | 0.90 |
ENST00000327669.4 |
FAM110C |
family with sequence similarity 110, member C |
| chr12_+_20848282 | 0.88 |
ENST00000545604.1 |
SLCO1C1 |
solute carrier organic anion transporter family, member 1C1 |
| chr12_+_20848377 | 0.82 |
ENST00000540354.1 ENST00000266509.2 ENST00000381552.1 |
SLCO1C1 |
solute carrier organic anion transporter family, member 1C1 |
| chr7_-_41742697 | 0.73 |
ENST00000242208.4 |
INHBA |
inhibin, beta A |
| chr11_+_1889880 | 0.73 |
ENST00000405957.2 |
LSP1 |
lymphocyte-specific protein 1 |
| chr1_+_153746683 | 0.71 |
ENST00000271857.2 |
SLC27A3 |
solute carrier family 27 (fatty acid transporter), member 3 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 2.0 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 1.8 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.3 | 1.7 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.0 | 1.6 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.3 | 1.5 | GO:0097021 | lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.1 | 1.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 1.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 1.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 1.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.3 | 2.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 2.1 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.5 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 1.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 1.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 1.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.0 | 1.1 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 1.7 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.2 | 1.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.5 | 1.4 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.1 | 1.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 1.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 1.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 1.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 1.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.8 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 1.8 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.8 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |