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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for NKX2-6

Z-value: 1.04

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NKX2-6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_60337684 1.85 ENST00000267484.5
 RTN1
 reticulon 1
chr12_+_56075330 1.81 ENST00000394252.3
 METTL7B
 methyltransferase like 7B
chr12_-_56236690 1.47 ENST00000322569.4
 MMP19
 matrix metallopeptidase 19
chr4_+_70916119 1.43 ENST00000246896.3
ENST00000511674.1
 HTN1
 histatin 1
chr8_-_120651020 1.01 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
 ENPP2
 ectonucleotide pyrophosphatase/phosphodiesterase 2
chr22_+_31160239 0.76 ENST00000445781.1
ENST00000401475.1
 OSBP2
 oxysterol binding protein 2
chr5_-_111091948 0.76 ENST00000447165.2
 NREP
 neuronal regeneration related protein
chr11_+_65265141 0.68 ENST00000534336.1
 MALAT1
 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr1_-_227505289 0.62 ENST00000366765.3
 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
chr2_-_163100045 0.51 ENST00000188790.4
 FAP
 fibroblast activation protein, alpha
chr10_-_27529486 0.51 ENST00000375888.1
 ACBD5
 acyl-CoA binding domain containing 5
chr2_-_163099885 0.50 ENST00000443424.1
 FAP
 fibroblast activation protein, alpha
chr5_+_140723601 0.49 ENST00000253812.6
 PCDHGA3
 protocadherin gamma subfamily A, 3
chr8_+_27629459 0.45 ENST00000523566.1
 ESCO2
 establishment of sister chromatid cohesion N-acetyltransferase 2
chr12_-_39300071 0.44 ENST00000550863.1
 CPNE8
 copine VIII
chr9_+_96846740 0.44 ENST00000288976.3
 PTPDC1
 protein tyrosine phosphatase domain containing 1
chr5_-_139937895 0.44 ENST00000336283.6
 SRA1
 steroid receptor RNA activator 1
chr10_-_13342097 0.43 ENST00000263038.4
 PHYH
 phytanoyl-CoA 2-hydroxylase
chr18_+_7754957 0.43 ENST00000400053.4
 PTPRM
 protein tyrosine phosphatase, receptor type, M
chr2_-_175462934 0.40 ENST00000392546.2
ENST00000436221.1
 WIPF1
 WAS/WASL interacting protein family, member 1
chr3_-_114790179 0.38 ENST00000462705.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr11_-_118901559 0.37 ENST00000330775.7
ENST00000545985.1
ENST00000357590.5
ENST00000538950.1
 SLC37A4
 solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr12_-_89920030 0.37 ENST00000413530.1
ENST00000547474.1
 GALNT4
POC1B-GALNT4
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr12_+_60083118 0.36 ENST00000261187.4
ENST00000543448.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr10_-_101841588 0.34 ENST00000370418.3
 CPN1
 carboxypeptidase N, polypeptide 1
chr17_-_7216939 0.33 ENST00000573684.1
 GPS2
 G protein pathway suppressor 2
chr4_+_113739244 0.32 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
 ANK2
 ankyrin 2, neuronal
chr12_+_44152740 0.32 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
 IRAK4
 interleukin-1 receptor-associated kinase 4
chr14_+_52164820 0.32 ENST00000554167.1
 FRMD6
 FERM domain containing 6
chr1_+_144989309 0.32 ENST00000596396.1
 AL590452.1
 Uncharacterized protein
chr4_-_1685718 0.31 ENST00000472884.2
ENST00000489363.1
ENST00000308132.6
ENST00000463238.1
 FAM53A
 family with sequence similarity 53, member A
chr11_-_62521614 0.31 ENST00000527994.1
ENST00000394807.3
 ZBTB3
 zinc finger and BTB domain containing 3
chr15_-_56757329 0.30 ENST00000260453.3
 MNS1
 meiosis-specific nuclear structural 1
chr5_+_78407602 0.30 ENST00000274353.5
ENST00000524080.1
 BHMT
 betaine--homocysteine S-methyltransferase
chr11_+_111126707 0.29 ENST00000280325.4
 C11orf53
 chromosome 11 open reading frame 53
chr6_-_15586238 0.29 ENST00000462989.2
 DTNBP1
 dystrobrevin binding protein 1
chr13_+_115000556 0.28 ENST00000252458.6
 CDC16
 cell division cycle 16
chr22_-_24096562 0.28 ENST00000398465.3
 VPREB3
 pre-B lymphocyte 3
chr11_-_64527425 0.27 ENST00000377432.3
 PYGM
 phosphorylase, glycogen, muscle
chr4_+_17579110 0.27 ENST00000606142.1
 LAP3
 leucine aminopeptidase 3
chr7_+_142498725 0.27 ENST00000466254.1
 TRBC2
 T cell receptor beta constant 2
chr19_+_39903185 0.27 ENST00000409794.3
 PLEKHG2
 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr13_+_115000521 0.26 ENST00000252457.5
ENST00000375308.1
 CDC16
 cell division cycle 16
chr4_-_156875003 0.26 ENST00000433477.3
 CTSO
 cathepsin O
chr3_-_42003479 0.26 ENST00000420927.1
 ULK4
 unc-51 like kinase 4
chr9_+_35906176 0.25 ENST00000354323.2
 HRCT1
 histidine rich carboxyl terminus 1
chr1_-_48866517 0.24 ENST00000371841.1
 SPATA6
 spermatogenesis associated 6
chr3_-_127541194 0.24 ENST00000453507.2
 MGLL
 monoglyceride lipase
chr9_-_134406565 0.24 ENST00000372210.3
ENST00000372211.3
 UCK1
 uridine-cytidine kinase 1
chr20_-_271009 0.24 ENST00000382369.5
 C20orf96
 chromosome 20 open reading frame 96
chr11_-_65629497 0.24 ENST00000532134.1
 CFL1
 cofilin 1 (non-muscle)
chr17_+_66521936 0.23 ENST00000592800.1
 PRKAR1A
 protein kinase, cAMP-dependent, regulatory, type I, alpha
chr11_-_105892937 0.23 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
 MSANTD4
 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr17_+_58755184 0.23 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
 BCAS3
 breast carcinoma amplified sequence 3
chr13_+_44453969 0.23 ENST00000325686.6
 LACC1
 laccase (multicopper oxidoreductase) domain containing 1
chr17_-_41116454 0.22 ENST00000427569.2
ENST00000430739.1
 AARSD1
 alanyl-tRNA synthetase domain containing 1
chr9_-_134406611 0.22 ENST00000372208.3
ENST00000372215.4
 UCK1
 uridine-cytidine kinase 1
chr9_+_125133315 0.21 ENST00000223423.4
ENST00000362012.2
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_39234074 0.21 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
 XIRP1
 xin actin-binding repeat containing 1
chr17_+_33914460 0.21 ENST00000537622.2
 AP2B1
 adaptor-related protein complex 2, beta 1 subunit
chr6_+_126102292 0.20 ENST00000368357.3
 NCOA7
 nuclear receptor coactivator 7
chr15_-_20170354 0.20 ENST00000338912.5
 IGHV1OR15-9
 immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr11_+_65627865 0.20 ENST00000308110.4
 MUS81
 MUS81 structure-specific endonuclease subunit
chr22_-_24096630 0.20 ENST00000248948.3
 VPREB3
 pre-B lymphocyte 3
chrX_-_153637612 0.20 ENST00000369807.1
ENST00000369808.3
 DNASE1L1
 deoxyribonuclease I-like 1
chr1_+_202431859 0.20 ENST00000391959.3
ENST00000367270.4
 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
chr2_-_175462456 0.19 ENST00000409891.1
ENST00000410117.1
 WIPF1
 WAS/WASL interacting protein family, member 1
chr10_+_124670121 0.19 ENST00000368894.1
 FAM24A
 family with sequence similarity 24, member A
chr19_-_49552006 0.19 ENST00000391869.3
 CGB1
 chorionic gonadotropin, beta polypeptide 1
chr1_+_64936428 0.19 ENST00000371073.2
ENST00000290039.5
 CACHD1
 cache domain containing 1
chr9_-_137809718 0.18 ENST00000371806.3
 FCN1
 ficolin (collagen/fibrinogen domain containing) 1
chr3_-_160167301 0.18 ENST00000494486.1
 TRIM59
 tripartite motif containing 59
chr14_+_50779071 0.18 ENST00000426751.2
 ATP5S
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr3_-_81811312 0.18 ENST00000429644.2
 GBE1
 glucan (1,4-alpha-), branching enzyme 1
chr2_-_27545921 0.18 ENST00000402310.1
ENST00000405983.1
ENST00000403262.2
ENST00000428910.1
ENST00000402722.1
ENST00000399052.4
ENST00000380044.1
ENST00000405076.1
 MPV17
 MpV17 mitochondrial inner membrane protein
chrX_-_47518527 0.17 ENST00000333119.3
 UXT
 ubiquitously-expressed, prefoldin-like chaperone
chr12_-_44152551 0.17 ENST00000416848.2
ENST00000550784.1
ENST00000547156.1
ENST00000549868.1
ENST00000553166.1
ENST00000551923.1
ENST00000431332.3
ENST00000344862.5
 PUS7L
 pseudouridylate synthase 7 homolog (S. cerevisiae)-like
chrX_-_47518498 0.17 ENST00000335890.2
 UXT
 ubiquitously-expressed, prefoldin-like chaperone
chr16_+_58783542 0.17 ENST00000500117.1
ENST00000565722.1
 RP11-410D17.2
 RP11-410D17.2
chr1_+_158969752 0.17 ENST00000566111.1
 IFI16
 interferon, gamma-inducible protein 16
chr16_-_20367584 0.17 ENST00000570689.1
 UMOD
 uromodulin
chr12_+_129028500 0.17 ENST00000315208.8
 TMEM132C
 transmembrane protein 132C
chr14_+_31494672 0.16 ENST00000542754.2
ENST00000313566.6
 AP4S1
 adaptor-related protein complex 4, sigma 1 subunit
chr22_+_44577724 0.16 ENST00000466375.2
 PARVG
 parvin, gamma
chr5_-_140070897 0.16 ENST00000448240.1
ENST00000438307.2
ENST00000415192.2
ENST00000457527.2
ENST00000307633.3
ENST00000507746.1
ENST00000431330.2
 HARS
 histidyl-tRNA synthetase
chr5_-_133510456 0.16 ENST00000520417.1
 SKP1
 S-phase kinase-associated protein 1
chr9_+_134065506 0.15 ENST00000483497.2
 NUP214
 nucleoporin 214kDa
chr17_+_33914276 0.15 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
 AP2B1
 adaptor-related protein complex 2, beta 1 subunit
chr19_+_50433476 0.15 ENST00000596658.1
 ATF5
 activating transcription factor 5
chr5_+_140071178 0.15 ENST00000508522.1
ENST00000448069.2
 HARS2
 histidyl-tRNA synthetase 2, mitochondrial
chr17_-_55911970 0.15 ENST00000581805.1
ENST00000580960.1
 RP11-60A24.3
 RP11-60A24.3
chr6_+_10528560 0.15 ENST00000379597.3
 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr7_+_100466433 0.15 ENST00000429658.1
 TRIP6
 thyroid hormone receptor interactor 6
chr16_+_69796209 0.14 ENST00000359154.2
ENST00000561780.1
ENST00000563659.1
ENST00000448661.1
 WWP2
 WW domain containing E3 ubiquitin protein ligase 2
chr20_+_32254286 0.14 ENST00000330271.4
 ACTL10
 actin-like 10
chr12_-_109531264 0.14 ENST00000429722.2
ENST00000536242.1
ENST00000343075.3
ENST00000536358.1
 ALKBH2
 alkB, alkylation repair homolog 2 (E. coli)
chr5_+_140071011 0.14 ENST00000230771.3
ENST00000509299.1
ENST00000503873.1
ENST00000435019.2
ENST00000437649.2
ENST00000432671.2
 HARS2
 histidyl-tRNA synthetase 2, mitochondrial
chr3_+_114012819 0.14 ENST00000383671.3
 TIGIT
 T cell immunoreceptor with Ig and ITIM domains
chr6_-_159466042 0.14 ENST00000338313.5
 TAGAP
 T-cell activation RhoGTPase activating protein
chr10_+_38717074 0.14 ENST00000423687.1
 LINC00999
 long intergenic non-protein coding RNA 999
chr16_-_23724518 0.14 ENST00000457008.2
 ERN2
 endoplasmic reticulum to nucleus signaling 2
chr20_-_32262165 0.13 ENST00000606690.1
ENST00000246190.6
ENST00000439478.1
ENST00000375238.4
 NECAB3
 N-terminal EF-hand calcium binding protein 3
chr8_+_42396712 0.13 ENST00000518574.1
ENST00000417410.2
ENST00000414154.2
 SMIM19
 small integral membrane protein 19
chr8_-_62602327 0.13 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
 ASPH
 aspartate beta-hydroxylase
chr3_-_48130707 0.13 ENST00000360240.6
ENST00000383737.4
 MAP4
 microtubule-associated protein 4
chr9_-_215744 0.13 ENST00000382387.2
 C9orf66
 chromosome 9 open reading frame 66
chr13_+_24883703 0.13 ENST00000332018.4
 C1QTNF9
 C1q and tumor necrosis factor related protein 9
chr17_-_2966901 0.13 ENST00000575751.1
 OR1D5
 olfactory receptor, family 1, subfamily D, member 5
chr14_+_31494841 0.13 ENST00000556232.1
ENST00000216366.4
ENST00000334725.4
ENST00000554609.1
ENST00000554345.1
 AP4S1
 adaptor-related protein complex 4, sigma 1 subunit
chr1_-_21113105 0.13 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
 HP1BP3
 heterochromatin protein 1, binding protein 3
chr9_+_131452239 0.13 ENST00000372688.4
ENST00000372686.5
 SET
 SET nuclear oncogene
chr3_-_39196049 0.12 ENST00000514182.1
 CSRNP1
 cysteine-serine-rich nuclear protein 1
chr21_-_31852663 0.12 ENST00000390689.2
 KRTAP19-1
 keratin associated protein 19-1
chr19_-_49552363 0.12 ENST00000448456.3
ENST00000355414.2
 CGB8
 chorionic gonadotropin, beta polypeptide 8
chr11_-_104480019 0.12 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
 RP11-886D15.1
 RP11-886D15.1
chr19_+_10563567 0.12 ENST00000344979.3
 PDE4A
 phosphodiesterase 4A, cAMP-specific
chr5_-_176889381 0.12 ENST00000393563.4
ENST00000512501.1
 DBN1
 drebrin 1
chr3_+_186358148 0.12 ENST00000382134.3
ENST00000265029.3
 FETUB
 fetuin B
chr2_-_25565377 0.11 ENST00000264709.3
ENST00000406659.3
 DNMT3A
 DNA (cytosine-5-)-methyltransferase 3 alpha
chr19_-_39881669 0.11 ENST00000221266.7
 PAF1
 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr1_-_115259337 0.11 ENST00000369535.4
 NRAS
 neuroblastoma RAS viral (v-ras) oncogene homolog
chr2_+_203776937 0.11 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
 CARF
 calcium responsive transcription factor
chr1_-_203144941 0.11 ENST00000255416.4
 MYBPH
 myosin binding protein H
chr7_-_56101826 0.11 ENST00000421626.1
 PSPH
 phosphoserine phosphatase
chr5_-_175612149 0.10 ENST00000515403.1
 RP11-844P9.2
 RP11-844P9.2
chr4_-_186317034 0.10 ENST00000505916.1
 LRP2BP
 LRP2 binding protein
chr20_-_1373682 0.10 ENST00000381724.3
 FKBP1A
 FK506 binding protein 1A, 12kDa
chr14_+_100531615 0.10 ENST00000392920.3
 EVL
 Enah/Vasp-like
chr16_-_47493041 0.10 ENST00000565940.2
 ITFG1
 integrin alpha FG-GAP repeat containing 1
chr10_+_18629628 0.10 ENST00000377329.4
 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
chr19_+_496454 0.10 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
 MADCAM1
 mucosal vascular addressin cell adhesion molecule 1
chr13_-_44453826 0.10 ENST00000444614.3
 CCDC122
 coiled-coil domain containing 122
chr10_+_115939008 0.10 ENST00000369282.1
ENST00000251864.2
ENST00000369281.2
ENST00000422662.1
 TDRD1
 tudor domain containing 1
chr5_+_52083730 0.10 ENST00000282588.6
ENST00000274311.2
 ITGA1
PELO
 integrin, alpha 1
pelota homolog (Drosophila)
chr1_+_110162448 0.10 ENST00000342115.4
ENST00000469039.2
ENST00000474459.1
ENST00000528667.1
 AMPD2
 adenosine monophosphate deaminase 2
chr12_-_89919965 0.10 ENST00000548729.1
 POC1B-GALNT4
 POC1B-GALNT4 readthrough
chr17_+_44370099 0.10 ENST00000496930.1
 LRRC37A
 leucine rich repeat containing 37A
chr9_+_125132803 0.09 ENST00000540753.1
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_173793458 0.09 ENST00000356198.2
 CENPL
 centromere protein L
chr2_-_69870747 0.09 ENST00000409068.1
 AAK1
 AP2 associated kinase 1
chr1_-_173793246 0.09 ENST00000345664.6
ENST00000367710.3
 CENPL
 centromere protein L
chr12_-_50294033 0.09 ENST00000552669.1
 FAIM2
 Fas apoptotic inhibitory molecule 2
chr22_+_22749343 0.09 ENST00000390298.2
 IGLV7-43
 immunoglobulin lambda variable 7-43
chr7_-_150777949 0.09 ENST00000482571.1
 FASTK
 Fas-activated serine/threonine kinase
chr14_+_22265444 0.09 ENST00000390430.2
 TRAV8-1
 T cell receptor alpha variable 8-1
chr17_-_57229155 0.09 ENST00000584089.1
 SKA2
 spindle and kinetochore associated complex subunit 2
chr20_-_21494654 0.09 ENST00000377142.4
 NKX2-2
 NK2 homeobox 2
chr7_-_150777874 0.09 ENST00000540185.1
 FASTK
 Fas-activated serine/threonine kinase
chr3_+_37035289 0.08 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
 MLH1
 mutL homolog 1
chr16_-_69373396 0.08 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
 COG8
 component of oligomeric golgi complex 8
chr8_+_42396936 0.08 ENST00000416469.2
 SMIM19
 small integral membrane protein 19
chr11_+_118958689 0.08 ENST00000535253.1
ENST00000392841.1
 HMBS
 hydroxymethylbilane synthase
chr11_-_129817356 0.08 ENST00000526082.1
 PRDM10
 PR domain containing 10
chr4_+_169418255 0.08 ENST00000505667.1
ENST00000511948.1
 PALLD
 palladin, cytoskeletal associated protein
chr10_+_135204338 0.08 ENST00000468317.2
 RP11-108K14.8
 Mitochondrial GTPase 1
chr2_+_132160448 0.08 ENST00000437751.1
 AC073869.19
 long intergenic non-protein coding RNA 1120
chr15_+_84841242 0.08 ENST00000558195.1
 RP11-182J1.16
 ubiquitin-conjugating enzyme E2Q family member 2-like
chr19_-_37663332 0.08 ENST00000392157.2
 ZNF585A
 zinc finger protein 585A
chr5_-_42825983 0.08 ENST00000506577.1
 SEPP1
 selenoprotein P, plasma, 1
chr19_+_58144529 0.08 ENST00000347302.3
ENST00000254182.7
ENST00000391703.3
ENST00000541801.1
ENST00000299871.5
ENST00000544273.1
 ZNF211
 zinc finger protein 211
chr22_+_23229960 0.08 ENST00000526893.1
ENST00000532223.2
ENST00000531372.1
 IGLL5
 immunoglobulin lambda-like polypeptide 5
chr17_+_25621102 0.07 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
 WSB1
 WD repeat and SOCS box containing 1
chr11_+_27062272 0.07 ENST00000529202.1
ENST00000533566.1
 BBOX1
 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr15_+_65843130 0.07 ENST00000569894.1
 PTPLAD1
 protein tyrosine phosphatase-like A domain containing 1
chr7_-_38389573 0.07 ENST00000390344.2
 TRGV5
 T cell receptor gamma variable 5
chr20_-_36661826 0.07 ENST00000373448.2
ENST00000373447.3
 TTI1
 TELO2 interacting protein 1
chr19_-_37663572 0.07 ENST00000588354.1
ENST00000292841.5
ENST00000355533.2
ENST00000356958.4
 ZNF585A
 zinc finger protein 585A
chr9_+_131447342 0.07 ENST00000409104.3
 SET
 SET nuclear oncogene
chrX_-_47341928 0.07 ENST00000313116.7
 ZNF41
 zinc finger protein 41
chr21_-_43735628 0.07 ENST00000291525.10
ENST00000518498.1
 TFF3
 trefoil factor 3 (intestinal)
chrX_+_47053208 0.07 ENST00000442035.1
ENST00000457753.1
ENST00000335972.6
 UBA1
 ubiquitin-like modifier activating enzyme 1
chr2_+_219246746 0.06 ENST00000233202.6
 SLC11A1
 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr7_+_101917407 0.06 ENST00000487284.1
 CUX1
 cut-like homeobox 1
chr9_-_111882195 0.06 ENST00000374586.3
 TMEM245
 transmembrane protein 245
chr14_+_64680854 0.06 ENST00000458046.2
 SYNE2
 spectrin repeat containing, nuclear envelope 2
chr9_-_33402506 0.06 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
 AQP7
 aquaporin 7
chr1_-_169337176 0.06 ENST00000472647.1
ENST00000367811.3
 NME7
 NME/NM23 family member 7
chr1_-_198509804 0.06 ENST00000489986.1
ENST00000367382.1
 ATP6V1G3
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
chr7_-_150777920 0.06 ENST00000353841.2
ENST00000297532.6
 FASTK
 Fas-activated serine/threonine kinase
chr2_+_86426478 0.06 ENST00000254644.8
ENST00000605125.1
ENST00000337109.4
ENST00000409180.1
 MRPL35
 mitochondrial ribosomal protein L35
chr12_-_75603482 0.06 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
 KCNC2
 potassium voltage-gated channel, Shaw-related subfamily, member 2
chr4_+_169418195 0.06 ENST00000261509.6
ENST00000335742.7
 PALLD
 palladin, cytoskeletal associated protein
chr22_+_42017987 0.06 ENST00000405506.1
 XRCC6
 X-ray repair complementing defective repair in Chinese hamster cells 6
chr15_-_55563072 0.06 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
 RAB27A
 RAB27A, member RAS oncogene family
chr7_+_128116783 0.06 ENST00000262432.8
ENST00000480046.1
 METTL2B
 methyltransferase like 2B
chr5_+_173763250 0.06 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
 RP11-267A15.1
 RP11-267A15.1
chr3_-_157824292 0.06 ENST00000483851.2
 SHOX2
 short stature homeobox 2
chr17_-_34329084 0.05 ENST00000354059.4
ENST00000536149.1
 CCL15
CCL14
 chemokine (C-C motif) ligand 15
chemokine (C-C motif) ligand 14
chr6_-_110012380 0.05 ENST00000424296.2
ENST00000341338.6
ENST00000368948.2
ENST00000285397.5
 AK9
 adenylate kinase 9
chr11_+_122709200 0.05 ENST00000227348.4
 CRTAM
 cytotoxic and regulatory T cell molecule
chrX_+_139791917 0.05 ENST00000607004.1
ENST00000370535.3
 LINC00632
 long intergenic non-protein coding RNA 632
chr17_-_34890709 0.05 ENST00000544606.1
 MYO19
 myosin XIX
chr12_-_50290839 0.05 ENST00000552863.1
 FAIM2
 Fas apoptotic inhibitory molecule 2
chr3_+_100428188 0.05 ENST00000418917.2
ENST00000490574.1
 TFG
 TRK-fused gene
chr17_-_47723943 0.05 ENST00000510476.1
ENST00000503676.1
 SPOP
 speckle-type POZ protein
chr5_-_43412418 0.05 ENST00000537013.1
ENST00000361115.4
 CCL28
 chemokine (C-C motif) ligand 28
chr2_+_109335929 0.05 ENST00000283195.6
 RANBP2
 RAN binding protein 2
chr1_+_113010056 0.05 ENST00000369686.5
 WNT2B
 wingless-type MMTV integration site family, member 2B
chr11_-_66360548 0.05 ENST00000333861.3
 CCDC87
 coiled-coil domain containing 87
chr22_+_44577237 0.04 ENST00000415224.1
ENST00000417767.1
 PARVG
 parvin, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097325 melanocyte proliferation(GO:0097325)
0.2 1.5 GO:0001554 luteolysis(GO:0001554)
0.2 0.5 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.1 0.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.3 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.5 GO:0030242 pexophagy(GO:0030242)
0.1 0.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.2 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.5 GO:0044211 CTP salvage(GO:0044211)
0.1 0.2 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.3 GO:0003383 apical constriction(GO:0003383)
0.0 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.3 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.4 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.2 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.1 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 1.4 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0055073 cadmium ion homeostasis(GO:0055073) divalent metal ion export(GO:0070839)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.3 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0061566 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.2 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.3 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.0 0.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.4 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.0 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 0.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.2 0.5 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.1 0.3 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.2 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.4 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.8 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.5 GO:0004849 uridine kinase activity(GO:0004849)
0.0 1.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.2 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones