Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
Navigation
Downloads
Results for NR2E3
Z-value: 1.45
Motif logo
Transcription factors associated with NR2E3
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_60337684 | 3.65 |
ENST00000267484.5 |
RTN1 |
reticulon 1 |
| chr13_+_102104980 | 3.43 |
ENST00000545560.2 |
ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
| chr13_+_102104952 | 3.09 |
ENST00000376180.3 |
ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
| chr7_+_94023873 | 2.30 |
ENST00000297268.6 |
COL1A2 |
collagen, type I, alpha 2 |
| chr12_-_91539918 | 2.09 |
ENST00000548218.1 |
DCN |
decorin |
| chr2_+_33359646 | 1.82 |
ENST00000390003.4 ENST00000418533.2 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chr10_-_93392811 | 1.80 |
ENST00000238994.5 |
PPP1R3C |
protein phosphatase 1, regulatory subunit 3C |
| chr2_+_33359687 | 1.79 |
ENST00000402934.1 ENST00000404525.1 ENST00000407925.1 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chr2_-_145277569 | 1.70 |
ENST00000303660.4 |
ZEB2 |
zinc finger E-box binding homeobox 2 |
| chr3_-_195310802 | 1.67 |
ENST00000421243.1 ENST00000453131.1 |
APOD |
apolipoprotein D |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.7 | 4.5 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.4 | 3.6 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 3.1 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 2.6 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.1 | 2.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.6 | 1.7 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.4 | 1.7 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.0 | 1.7 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.1 | 1.6 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.2 | 4.0 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 3.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 2.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 2.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 1.2 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 1.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.2 | 1.0 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 4.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.7 | 3.6 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 3.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.2 | 3.1 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 2.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 2.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 1.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 1.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 1.6 | GO:0070888 | E-box binding(GO:0070888) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 1.6 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.1 | 1.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.8 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.7 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.7 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.6 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |