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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for NRF1
Z-value: 3.79
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | 0.43 | 2.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_183605200 | 5.59 |
ENST00000304685.4 |
RGL1 |
ral guanine nucleotide dissociation stimulator-like 1 |
| chr3_+_49449636 | 4.40 |
ENST00000273590.3 |
TCTA |
T-cell leukemia translocation altered |
| chr12_-_124457371 | 4.24 |
ENST00000238156.3 ENST00000545037.1 |
CCDC92 |
coiled-coil domain containing 92 |
| chr20_-_34042558 | 3.89 |
ENST00000374372.1 |
GDF5 |
growth differentiation factor 5 |
| chr12_-_124457257 | 3.65 |
ENST00000545891.1 |
CCDC92 |
coiled-coil domain containing 92 |
| chr7_+_149571045 | 3.55 |
ENST00000479613.1 ENST00000606024.1 ENST00000464662.1 ENST00000425642.2 |
ATP6V0E2 |
ATPase, H+ transporting V0 subunit e2 |
| chrX_+_54835493 | 2.97 |
ENST00000396224.1 |
MAGED2 |
melanoma antigen family D, 2 |
| chr20_-_35580104 | 2.62 |
ENST00000373694.5 |
SAMHD1 |
SAM domain and HD domain 1 |
| chr22_+_24666763 | 2.60 |
ENST00000437398.1 ENST00000421374.1 ENST00000314328.9 ENST00000541492.1 |
SPECC1L |
sperm antigen with calponin homology and coiled-coil domains 1-like |
| chr17_+_260097 | 2.53 |
ENST00000360127.6 ENST00000571106.1 ENST00000491373.1 |
C17orf97 |
chromosome 17 open reading frame 97 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.5 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.2 | 7.0 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.8 | 6.4 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 6.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.3 | 5.1 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.9 | 4.7 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.0 | 4.7 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.3 | 4.5 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.7 | 4.4 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.0 | 4.2 | GO:0046546 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.4 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 7.2 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 6.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 6.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 4.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 4.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.2 | 4.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 3.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 3.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.4 | 3.6 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 7.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 6.9 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) |
| 0.0 | 6.0 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.9 | 5.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 5.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.6 | 4.9 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
| 0.0 | 4.7 | GO:0060090 | binding, bridging(GO:0060090) |
| 0.1 | 4.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.3 | 3.9 | GO:0036122 | BMP binding(GO:0036122) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 4.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 4.1 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 3.9 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 3.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 3.5 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 3.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 3.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 3.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 3.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 6.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 4.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 3.7 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.2 | 3.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 3.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 3.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.5 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |