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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for PATZ1_KLF4
Z-value: 1.85
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Transcription factors associated with PATZ1_KLF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF4 | hg19_v2_chr9_-_110251836_110251927 | -0.77 | 2.5e-02 | Click! |
| PATZ1 | hg19_v2_chr22_-_31741757_31741770 | -0.48 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PATZ1_KLF4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_55658687 | 4.92 |
ENST00000593046.1 |
TNNT1 |
troponin T type 1 (skeletal, slow) |
| chr19_-_55658650 | 4.47 |
ENST00000589226.1 |
TNNT1 |
troponin T type 1 (skeletal, slow) |
| chr18_+_11981427 | 3.99 |
ENST00000269159.3 |
IMPA2 |
inositol(myo)-1(or 4)-monophosphatase 2 |
| chr18_+_11981547 | 3.77 |
ENST00000588927.1 |
IMPA2 |
inositol(myo)-1(or 4)-monophosphatase 2 |
| chr18_+_11981014 | 3.56 |
ENST00000589238.1 |
IMPA2 |
inositol(myo)-1(or 4)-monophosphatase 2 |
| chr19_-_55658281 | 3.35 |
ENST00000585321.2 ENST00000587465.2 |
TNNT1 |
troponin T type 1 (skeletal, slow) |
| chr14_-_105635090 | 3.16 |
ENST00000331782.3 ENST00000347004.2 |
JAG2 |
jagged 2 |
| chr19_-_6767516 | 3.14 |
ENST00000245908.6 |
SH2D3A |
SH2 domain containing 3A |
| chr19_-_291365 | 3.12 |
ENST00000591572.1 ENST00000269812.3 ENST00000434325.2 |
PPAP2C |
phosphatidic acid phosphatase type 2C |
| chr1_-_11714700 | 3.12 |
ENST00000354287.4 |
FBXO2 |
F-box protein 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 15.4 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 2.1 | 12.5 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.1 | 11.9 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 8.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 8.3 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.5 | 7.7 | GO:0021894 | cerebral cortex GABAergic interneuron development(GO:0021894) |
| 1.2 | 7.0 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.6 | 6.4 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 0.4 | 6.0 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 5.4 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.8 | 20.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 11.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 11.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 11.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 9.8 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 7.7 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 7.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.0 | 7.0 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.4 | 6.0 | GO:0035253 | ciliary rootlet(GO:0035253) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 19.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 12.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.2 | 11.1 | GO:0052834 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.0 | 10.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 10.2 | GO:0005525 | GTP binding(GO:0005525) |
| 0.2 | 9.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.2 | 9.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 9.1 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.3 | 8.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 8.5 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 7.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 6.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 5.8 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.2 | 5.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 4.8 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 4.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 4.6 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 4.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 4.4 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 14.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 10.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 9.0 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 8.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 7.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 6.5 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.3 | 6.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 6.2 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.1 | 6.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |