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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for PITX2

Z-value: 0.19

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
ENSG00000164093.11 PITX2

Activity-expression correlation:

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_126237554 0.23 ENST00000394329.3
FAT4
FAT atypical cadherin 4
chr4_+_70916119 0.20 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr2_+_120770581 0.18 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr19_+_2476116 0.16 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr2_+_120770645 0.10 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr8_-_27462822 0.08 ENST00000522098.1
CLU
clusterin
chr1_-_31230650 0.07 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr12_-_90049828 0.07 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049878 0.07 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr11_-_96076334 0.06 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr6_-_111804905 0.05 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chrX_-_48931648 0.04 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr10_+_18240834 0.04 ENST00000377371.3
ENST00000539911.1
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr1_-_165414414 0.04 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr10_+_103986085 0.04 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr9_-_110251836 0.04 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr5_-_64920115 0.04 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr7_-_128415844 0.04 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr2_+_201994569 0.03 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr9_+_34458771 0.03 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr6_+_46661575 0.03 ENST00000450697.1
TDRD6
tudor domain containing 6
chr10_+_18240753 0.03 ENST00000377369.2
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr10_+_18240814 0.02 ENST00000377374.4
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr19_-_51893827 0.02 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chrM_+_9207 0.02 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr2_-_121223697 0.02 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr17_-_10633535 0.01 ENST00000341871.3
TMEM220
transmembrane protein 220
chr17_+_79495397 0.01 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr1_+_22328144 0.01 ENST00000290122.3
ENST00000374663.1
CELA3A
chymotrypsin-like elastase family, member 3A
chr11_-_119217365 0.01 ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
ENST00000445041.2
MFRP
C1QTNF5
membrane frizzled-related protein
C1q and tumor necrosis factor related protein 5
chr3_-_50388522 0.01 ENST00000232501.3
NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr3_+_119421849 0.01 ENST00000273390.5
ENST00000463700.1
MAATS1
MYCBP-associated, testis expressed 1
chr12_+_7941989 0.01 ENST00000229307.4
NANOG
Nanog homeobox
chr11_+_61522844 0.01 ENST00000265460.5
MYRF
myelin regulatory factor
chr15_+_54901540 0.01 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr21_-_19775973 0.01 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr3_+_158787041 0.01 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr5_+_64920543 0.01 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr1_+_22303503 0.01 ENST00000337107.6
CELA3B
chymotrypsin-like elastase family, member 3B
chr3_-_191000172 0.01 ENST00000427544.2
UTS2B
urotensin 2B
chr10_-_75193308 0.01 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chr19_-_19314162 0.01 ENST00000420605.3
ENST00000544883.1
ENST00000538165.2
ENST00000331552.7
NR2C2AP
nuclear receptor 2C2-associated protein
chr4_-_68620053 0.00 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr7_-_122840015 0.00 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr9_+_8858102 0.00 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr16_-_5116025 0.00 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chr1_+_201979645 0.00 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr2_+_3622893 0.00 ENST00000407445.3
ENST00000403564.1
RPS7
ribosomal protein S7
chr1_+_2407754 0.00 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr10_-_49482907 0.00 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.1 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.1 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 0.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.0 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)