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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for PKNOX2

Z-value: 0.36

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
ENSG00000165495.11 PKNOX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg19_v2_chr11_+_125034586_125034604-0.801.8e-02Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_+_33010175 0.48 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr16_+_2880157 0.30 ENST00000382280.3
ZG16B
zymogen granule protein 16B
chr9_-_79307096 0.27 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
PRUNE2
prune homolog 2 (Drosophila)
chr16_+_2880369 0.27 ENST00000572863.1
ZG16B
zymogen granule protein 16B
chr4_-_157892167 0.26 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr4_-_157892055 0.25 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr11_+_6411670 0.24 ENST00000530395.1
ENST00000527275.1
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr16_+_2880254 0.23 ENST00000570670.1
ZG16B
zymogen granule protein 16B
chr11_+_6411636 0.22 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr16_+_2880296 0.22 ENST00000571723.1
ZG16B
zymogen granule protein 16B
chr4_-_157892498 0.21 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr5_+_118407053 0.16 ENST00000311085.8
ENST00000539542.1
DMXL1
Dmx-like 1
chr6_-_87804815 0.16 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr9_-_73477826 0.15 ENST00000396285.1
ENST00000396292.4
ENST00000396280.5
ENST00000358082.3
ENST00000408909.2
ENST00000377097.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr3_-_52719810 0.14 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
PBRM1
polybromo 1
chr2_+_202316392 0.14 ENST00000194530.3
ENST00000392249.2
STRADB
STE20-related kinase adaptor beta
chr18_-_54305658 0.14 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chrX_-_39923656 0.13 ENST00000413905.1
BCOR
BCL6 corepressor
chr2_-_202316260 0.13 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr3_-_127541679 0.11 ENST00000265052.5
MGLL
monoglyceride lipase
chr3_-_101395936 0.11 ENST00000461821.1
ZBTB11
zinc finger and BTB domain containing 11
chrX_-_153775426 0.10 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr12_+_103981044 0.10 ENST00000388887.2
STAB2
stabilin 2
chr2_-_73460334 0.10 ENST00000258083.2
PRADC1
protease-associated domain containing 1
chr22_-_31885514 0.09 ENST00000397525.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr5_-_81046904 0.09 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr5_-_81046841 0.09 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2
single-stranded DNA binding protein 2
chr6_+_110299501 0.09 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr20_-_39946237 0.09 ENST00000441102.2
ENST00000559234.1
ZHX3
zinc fingers and homeoboxes 3
chr5_-_81046922 0.09 ENST00000514493.1
ENST00000320672.4
SSBP2
single-stranded DNA binding protein 2
chr6_+_108881012 0.09 ENST00000343882.6
FOXO3
forkhead box O3
chr22_-_50946113 0.08 ENST00000216080.5
ENST00000474879.2
ENST00000380796.3
LMF2
lipase maturation factor 2
chr10_+_94608245 0.08 ENST00000443748.2
ENST00000260762.6
EXOC6
exocyst complex component 6
chr6_-_116575226 0.08 ENST00000420283.1
TSPYL4
TSPY-like 4
chr7_-_148580563 0.08 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_-_52001448 0.08 ENST00000461554.1
ENST00000395013.3
ENST00000428823.2
ENST00000483411.1
ENST00000461544.1
ENST00000355852.2
PCBP4
poly(rC) binding protein 4
chr11_+_12132117 0.08 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr6_-_11382478 0.07 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr3_-_127541194 0.07 ENST00000453507.2
MGLL
monoglyceride lipase
chr15_-_37392086 0.07 ENST00000561208.1
MEIS2
Meis homeobox 2
chr4_+_166300084 0.07 ENST00000402744.4
CPE
carboxypeptidase E
chr5_-_132073111 0.06 ENST00000403231.1
KIF3A
kinesin family member 3A
chr7_-_137028498 0.06 ENST00000393083.2
PTN
pleiotrophin
chr18_+_3449330 0.06 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr11_-_111741994 0.05 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr17_-_72358001 0.05 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr5_-_127873896 0.05 ENST00000502468.1
FBN2
fibrillin 2
chr7_-_137028534 0.05 ENST00000348225.2
PTN
pleiotrophin
chr15_-_61521495 0.05 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr8_+_11666649 0.05 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chrX_-_71792477 0.05 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr18_+_3449695 0.05 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr16_-_1275257 0.05 ENST00000234798.4
TPSG1
tryptase gamma 1
chr15_+_57668695 0.05 ENST00000281282.5
CGNL1
cingulin-like 1
chr3_+_52828805 0.04 ENST00000416872.2
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr4_-_175750364 0.04 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr9_-_132805430 0.04 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
FNBP1
formin binding protein 1
chr2_+_128848881 0.04 ENST00000259253.6
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr11_-_842509 0.04 ENST00000322028.4
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr9_-_123639600 0.04 ENST00000373896.3
PHF19
PHD finger protein 19
chr9_-_123639304 0.04 ENST00000436309.1
PHF19
PHD finger protein 19
chr20_+_43514320 0.04 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr12_-_121734489 0.04 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr5_-_58882219 0.04 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_39759154 0.04 ENST00000331982.5
IFNL2
interferon, lambda 2
chr17_-_26220366 0.03 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr18_+_54318566 0.03 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr6_+_41021027 0.03 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr14_-_21492113 0.03 ENST00000554094.1
NDRG2
NDRG family member 2
chr10_-_101945771 0.03 ENST00000370408.2
ENST00000407654.3
ERLIN1
ER lipid raft associated 1
chr9_-_123639445 0.03 ENST00000312189.6
PHF19
PHD finger protein 19
chr17_-_35969409 0.03 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG
synergin, gamma
chr1_-_179112173 0.03 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr3_-_3221358 0.03 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr1_-_179112189 0.03 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr20_-_3065362 0.03 ENST00000380293.3
AVP
arginine vasopressin
chr8_+_57124245 0.03 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr6_-_84418841 0.03 ENST00000369694.2
ENST00000195649.6
SNAP91
synaptosomal-associated protein, 91kDa
chr3_+_185080908 0.03 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr2_+_128848740 0.03 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_+_169418255 0.03 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr11_-_19262486 0.03 ENST00000250024.4
E2F8
E2F transcription factor 8
chr6_-_84418860 0.03 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr1_-_35658736 0.03 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr20_-_61847586 0.02 ENST00000370339.3
YTHDF1
YTH domain family, member 1
chr2_-_211179883 0.02 ENST00000352451.3
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr6_-_32140886 0.02 ENST00000395496.1
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr4_+_169418195 0.02 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr12_+_113495492 0.02 ENST00000257600.3
DTX1
deltex homolog 1 (Drosophila)
chr11_+_120207787 0.02 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr6_-_37225391 0.02 ENST00000356757.2
TMEM217
transmembrane protein 217
chr13_+_33160553 0.02 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr9_+_137772652 0.02 ENST00000350339.2
ENST00000291744.6
FCN2
ficolin (collagen/fibrinogen domain containing lectin) 2
chr1_+_161736072 0.02 ENST00000367942.3
ATF6
activating transcription factor 6
chr2_+_191208196 0.02 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1
inositol polyphosphate-1-phosphatase
chr8_-_57123815 0.02 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr11_-_71810258 0.01 ENST00000544594.1
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr15_+_68346501 0.01 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr17_+_39868577 0.01 ENST00000329402.3
GAST
gastrin
chr12_+_49621658 0.01 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr22_+_17082732 0.01 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1
transmembrane phosphatase with tensin homology pseudogene 1
chr2_+_219524473 0.01 ENST00000439945.1
ENST00000431802.1
BCS1L
BC1 (ubiquinol-cytochrome c reductase) synthesis-like
chr16_-_30457048 0.01 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chrX_-_77225135 0.01 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr4_-_149365827 0.01 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr19_+_7733929 0.01 ENST00000221515.2
RETN
resistin
chr22_+_50946645 0.01 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
NCAPH2
non-SMC condensin II complex, subunit H2
chr1_+_74701062 0.01 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr5_+_125758865 0.01 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr11_+_74660278 0.01 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr16_+_50776021 0.01 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr1_+_154966058 0.01 ENST00000392487.1
LENEP
lens epithelial protein
chr3_+_46742823 0.01 ENST00000326431.3
TMIE
transmembrane inner ear
chr11_-_46867780 0.01 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
CKAP5
cytoskeleton associated protein 5
chr2_-_179672142 0.00 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
TTN
titin
chr10_+_28822636 0.00 ENST00000442148.1
ENST00000448193.1
WAC
WW domain containing adaptor with coiled-coil
chr3_+_32147997 0.00 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr10_+_70661014 0.00 ENST00000373585.3
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr2_-_219524193 0.00 ENST00000450560.1
ENST00000449707.1
ENST00000432460.1
ENST00000411696.2
ZNF142
zinc finger protein 142
chr6_+_31674639 0.00 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr11_-_64013288 0.00 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_+_125758813 0.00 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr6_-_114664180 0.00 ENST00000312719.5
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr16_-_57481278 0.00 ENST00000567751.1
ENST00000568940.1
ENST00000563341.1
ENST00000565961.1
ENST00000569370.1
ENST00000567518.1
ENST00000565786.1
ENST00000394391.4
CIAPIN1
cytokine induced apoptosis inhibitor 1
chr11_+_842928 0.00 ENST00000397408.1
TSPAN4
tetraspanin 4
chr1_+_181057638 0.00 ENST00000367577.4
IER5
immediate early response 5
chr6_+_42123141 0.00 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr1_+_66258846 0.00 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.5 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 1.0 GO:0001895 retina homeostasis(GO:0001895)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043291 RAVE complex(GO:0043291)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.0 GO:0016935 glycine-gated chloride channel complex(GO:0016935)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0016015 morphogen activity(GO:0016015)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.0 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones