Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
Navigation
Downloads
Results for PLAGL1
Z-value: 2.19
Motif logo
Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144385698_144385742 | -0.75 | 3.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_3028354 | 2.62 |
ENST00000586422.1 |
TLE2 |
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) |
| chr5_-_168727713 | 2.52 |
ENST00000404867.3 |
SLIT3 |
slit homolog 3 (Drosophila) |
| chr5_+_75699149 | 2.28 |
ENST00000379730.3 |
IQGAP2 |
IQ motif containing GTPase activating protein 2 |
| chr5_-_168727786 | 1.94 |
ENST00000332966.8 |
SLIT3 |
slit homolog 3 (Drosophila) |
| chr17_-_42276574 | 1.83 |
ENST00000589805.1 |
ATXN7L3 |
ataxin 7-like 3 |
| chr19_-_18653781 | 1.76 |
ENST00000596558.2 ENST00000453489.2 |
FKBP8 |
FK506 binding protein 8, 38kDa |
| chr5_+_75699040 | 1.76 |
ENST00000274364.6 |
IQGAP2 |
IQ motif containing GTPase activating protein 2 |
| chr9_+_90112767 | 1.66 |
ENST00000408954.3 |
DAPK1 |
death-associated protein kinase 1 |
| chr9_+_90112741 | 1.64 |
ENST00000469640.2 |
DAPK1 |
death-associated protein kinase 1 |
| chr11_-_3186494 | 1.62 |
ENST00000389989.3 ENST00000542243.1 |
OSBPL5 |
oxysterol binding protein-like 5 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | GO:1902807 | negative regulation of cell cycle G1/S phase transition(GO:1902807) |
| 0.3 | 5.7 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.8 | 5.0 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) |
| 0.1 | 4.5 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.0 | 4.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 4.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 3.9 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.2 | 3.8 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 3.8 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.0 | 3.8 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 9.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 6.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 6.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 6.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 5.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.5 | 5.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 4.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 4.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 4.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 12.5 | GO:0019001 | guanyl nucleotide binding(GO:0019001) |
| 0.0 | 11.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 9.6 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.1 | 6.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 5.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.6 | 5.3 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 4.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.4 | 4.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 4.5 | GO:0004407 | histone deacetylase activity(GO:0004407) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.3 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 4.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 4.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 4.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 3.4 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 3.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 7.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 6.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 6.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 5.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 5.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 4.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 4.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 4.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |