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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for POU3F2
Z-value: 1.07
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | 0.23 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_97597148 | 2.26 |
ENST00000521590.1 |
SDC2 |
syndecan 2 |
| chr13_-_38172863 | 1.78 |
ENST00000541481.1 ENST00000379743.4 ENST00000379742.4 ENST00000379749.4 ENST00000541179.1 ENST00000379747.4 |
POSTN |
periostin, osteoblast specific factor |
| chr12_-_91572278 | 1.70 |
ENST00000425043.1 ENST00000420120.2 ENST00000441303.2 ENST00000456569.2 |
DCN |
decorin |
| chr2_+_189839046 | 1.58 |
ENST00000304636.3 ENST00000317840.5 |
COL3A1 |
collagen, type III, alpha 1 |
| chr2_+_152214098 | 1.58 |
ENST00000243347.3 |
TNFAIP6 |
tumor necrosis factor, alpha-induced protein 6 |
| chr9_+_99690592 | 1.50 |
ENST00000354649.3 |
NUTM2G |
NUT family member 2G |
| chr3_+_157154578 | 1.40 |
ENST00000295927.3 |
PTX3 |
pentraxin 3, long |
| chr14_-_60097297 | 1.25 |
ENST00000395090.1 |
RTN1 |
reticulon 1 |
| chr11_+_5710919 | 1.22 |
ENST00000379965.3 ENST00000425490.1 |
TRIM22 |
tripartite motif containing 22 |
| chr5_+_110409012 | 1.17 |
ENST00000379706.4 |
TSLP |
thymic stromal lymphopoietin |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.4 | 2.3 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 2.0 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.4 | 1.8 | GO:0032571 | response to vitamin K(GO:0032571) bone regeneration(GO:1990523) |
| 0.2 | 1.4 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.3 | 1.3 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 0.1 | 1.3 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 0.0 | 1.3 | GO:0030728 | ovulation(GO:0030728) |
| 0.1 | 1.2 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 1.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.3 | 4.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 4.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 1.6 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 1.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 1.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.9 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 0.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 2.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 1.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 1.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 1.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 1.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 1.3 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.0 | 1.1 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.1 | 1.0 | GO:0015057 | thrombin receptor activity(GO:0015057) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 1.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 1.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.7 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 1.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.9 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |