ISMARA results: REST

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for REST

Z-value: 0.46

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Transcription factors associated with REST

Gene Symbol	Gene ID	Gene Info
REST Ensembl NCBI GeneCards UniProt	ENSG00000084093.11	REST

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REST	hg19_v2_chr4_+_57774042_57774114	-0.33	4.3e-01	Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chrX_-_153141302	0.77	ENST00000361699.4 ENST00000543994.1 ENST00000370057.3 ENST00000538883.1 ENST00000361981.3	L1CAM	L1 cell adhesion molecule
chr7_+_145813453	0.38	ENST00000361727.3	CNTNAP2	contactin associated protein-like 2
chr20_+_62327996	0.38	ENST00000369996.1	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_-_91095099	0.33	ENST00000265431.3	CALB1	calbindin 1, 28kDa
chr17_+_30813576	0.32	ENST00000313401.3	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr15_-_72612470	0.30	ENST00000287202.5	CELF6	CUGBP, Elav-like family member 6
chr11_-_72492878	0.26	ENST00000535054.1 ENST00000545082.1	STARD10	StAR-related lipid transfer (START) domain containing 10
chr10_-_50970382	0.25	ENST00000419399.1 ENST00000432695.1	OGDHL	oxoglutarate dehydrogenase-like
chr10_-_50970322	0.25	ENST00000374103.4	OGDHL	oxoglutarate dehydrogenase-like
chr7_+_154862028	0.24	ENST00000287907.2	HTR5A	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

Showing 1 to 10 of 98 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0045773	positive regulation of axon extension(GO:0045773)
0.1	0.5	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0	0.5	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.1	0.4	GO:0071109	superior temporal gyrus development(GO:0071109)
0.1	0.3	GO:0021722	superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0	0.3	GO:0035502	metanephric part of ureteric bud development(GO:0035502)
0.0	0.3	GO:0032782	bile acid secretion(GO:0032782)
0.1	0.2	GO:2000974	trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.1	0.2	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1	0.2	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)

Showing 1 to 10 of 23 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.5	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.4	GO:0033010	paranodal junction(GO:0033010)
0.1	0.3	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.2	GO:0030123	AP-3 adaptor complex(GO:0030123)
0.0	0.1	GO:0070554	synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)

Showing 1 to 7 of 7 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.5	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.3	GO:0016534	cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1	0.3	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.2	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0043176	amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0	0.2	GO:0008430	selenium binding(GO:0008430)
0.0	0.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)

Showing 1 to 10 of 11 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors

Showing 1 to 3 of 3 entries

Results for REST

Z-value: 0.46

Motif logo

Transcription factors associated with REST

Activity-expression correlation:

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: