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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for REST

Z-value: 0.46

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.334.3e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_-_153141302 0.77 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM
 L1 cell adhesion molecule
chr7_+_145813453 0.38 ENST00000361727.3
 CNTNAP2
 contactin associated protein-like 2
chr20_+_62327996 0.38 ENST00000369996.1
 TNFRSF6B
 tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_-_91095099 0.33 ENST00000265431.3
 CALB1
 calbindin 1, 28kDa
chr17_+_30813576 0.32 ENST00000313401.3
 CDK5R1
 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr15_-_72612470 0.30 ENST00000287202.5
 CELF6
 CUGBP, Elav-like family member 6
chr11_-_72492878 0.26 ENST00000535054.1
ENST00000545082.1
 STARD10
 StAR-related lipid transfer (START) domain containing 10
chr10_-_50970382 0.25 ENST00000419399.1
ENST00000432695.1
 OGDHL
 oxoglutarate dehydrogenase-like
chr10_-_50970322 0.25 ENST00000374103.4
 OGDHL
 oxoglutarate dehydrogenase-like
chr7_+_154862028 0.24 ENST00000287907.2
 HTR5A
 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
chr3_+_193853927 0.24 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chr8_-_145559943 0.23 ENST00000332135.4
 SCRT1
 scratch family zinc finger 1
chr20_-_62284766 0.23 ENST00000370053.1
 STMN3
 stathmin-like 3
chr9_+_138606400 0.21 ENST00000486577.2
 KCNT1
 potassium channel, subfamily T, member 1
chr2_+_46524537 0.20 ENST00000263734.3
 EPAS1
 endothelial PAS domain protein 1
chrX_-_49056635 0.19 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
 SYP
 synaptophysin
chr9_+_135457530 0.18 ENST00000263610.2
 BARHL1
 BarH-like homeobox 1
chr10_-_44880491 0.18 ENST00000374426.2
ENST00000395795.4
ENST00000395794.2
ENST00000374429.2
ENST00000395793.3
ENST00000343575.6
 CXCL12
 chemokine (C-X-C motif) ligand 12
chr8_+_6565854 0.17 ENST00000285518.6
 AGPAT5
 1-acylglycerol-3-phosphate O-acyltransferase 5
chr17_-_3337135 0.16 ENST00000248384.1
 OR1E2
 olfactory receptor, family 1, subfamily E, member 2
chr2_-_47798044 0.15 ENST00000327876.4
 KCNK12
 potassium channel, subfamily K, member 12
chr2_-_51259528 0.14 ENST00000404971.1
 NRXN1
 neurexin 1
chr3_+_120626919 0.14 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
 STXBP5L
 syntaxin binding protein 5-like
chr4_+_96012614 0.13 ENST00000264568.4
 BMPR1B
 bone morphogenetic protein receptor, type IB
chr2_-_51259641 0.13 ENST00000406316.2
ENST00000405581.1
 NRXN1
 neurexin 1
chr11_-_125773085 0.12 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
 PUS3
 pseudouridylate synthase 3
chr2_-_51259229 0.12 ENST00000405472.3
 NRXN1
 neurexin 1
chr2_-_51259292 0.12 ENST00000401669.2
 NRXN1
 neurexin 1
chr20_+_5892037 0.11 ENST00000378961.4
 CHGB
 chromogranin B (secretogranin 1)
chr19_-_3971050 0.11 ENST00000545797.2
ENST00000596311.1
 DAPK3
 death-associated protein kinase 3
chr14_-_106781017 0.10 ENST00000390612.2
 IGHV4-28
 immunoglobulin heavy variable 4-28
chr3_-_113897899 0.09 ENST00000383673.2
ENST00000295881.7
 DRD3
 dopamine receptor D3
chr11_-_92931098 0.08 ENST00000326402.4
 SLC36A4
 solute carrier family 36 (proton/amino acid symporter), member 4
chr15_-_83378526 0.08 ENST00000535348.1
ENST00000535359.1
 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
chr12_+_113229543 0.08 ENST00000447659.2
 RPH3A
 rabphilin 3A homolog (mouse)
chr14_+_93389425 0.08 ENST00000216492.5
ENST00000334654.4
 CHGA
 chromogranin A (parathyroid secretory protein 1)
chr12_+_175930 0.08 ENST00000538872.1
ENST00000326261.4
 IQSEC3
 IQ motif and Sec7 domain 3
chr19_-_11639910 0.07 ENST00000588998.1
ENST00000586149.1
 ECSIT
 ECSIT signalling integrator
chr12_+_113229452 0.07 ENST00000389385.4
 RPH3A
 rabphilin 3A homolog (mouse)
chr1_+_212606219 0.07 ENST00000366988.3
 NENF
 neudesin neurotrophic factor
chr16_+_335680 0.07 ENST00000435833.1
 PDIA2
 protein disulfide isomerase family A, member 2
chr15_-_83378638 0.07 ENST00000261722.3
 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
chrX_-_153237258 0.07 ENST00000310441.7
 HCFC1
 host cell factor C1 (VP16-accessory protein)
chr5_+_175298573 0.07 ENST00000512824.1
 CPLX2
 complexin 2
chr6_+_158957431 0.07 ENST00000367090.3
 TMEM181
 transmembrane protein 181
chr1_-_102462565 0.07 ENST00000370103.4
 OLFM3
 olfactomedin 3
chr15_-_83378611 0.06 ENST00000542200.1
 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
chr2_+_115199876 0.06 ENST00000436732.1
ENST00000410059.1
 DPP10
 dipeptidyl-peptidase 10 (non-functional)
chr17_-_27333311 0.06 ENST00000317338.12
ENST00000585644.1
 SEZ6
 seizure related 6 homolog (mouse)
chr13_-_111214015 0.06 ENST00000267328.3
 RAB20
 RAB20, member RAS oncogene family
chr6_+_35773070 0.06 ENST00000373853.1
ENST00000360215.1
 LHFPL5
 lipoma HMGIC fusion partner-like 5
chr1_+_210111570 0.06 ENST00000367019.1
ENST00000472886.1
 SYT14
 synaptotagmin XIV
chr20_+_36012051 0.06 ENST00000373567.2
 SRC
 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr3_-_113897545 0.06 ENST00000467632.1
 DRD3
 dopamine receptor D3
chr17_-_27332931 0.06 ENST00000442608.3
ENST00000335960.6
 SEZ6
 seizure related 6 homolog (mouse)
chr17_-_27333163 0.05 ENST00000360295.9
 SEZ6
 seizure related 6 homolog (mouse)
chr17_+_42385927 0.05 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
 RUNDC3A
 RUN domain containing 3A
chr19_-_11639931 0.05 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
 ECSIT
 ECSIT signalling integrator
chr5_+_63802109 0.05 ENST00000334025.2
 RGS7BP
 regulator of G-protein signaling 7 binding protein
chr12_+_113229737 0.05 ENST00000551052.1
ENST00000415485.3
 RPH3A
 rabphilin 3A homolog (mouse)
chr14_+_93897199 0.05 ENST00000553484.1
 UNC79
 unc-79 homolog (C. elegans)
chr14_+_93897272 0.05 ENST00000393151.2
 UNC79
 unc-79 homolog (C. elegans)
chr1_+_154540246 0.05 ENST00000368476.3
 CHRNB2
 cholinergic receptor, nicotinic, beta 2 (neuronal)
chr15_+_75287861 0.05 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
 SCAMP5
 secretory carrier membrane protein 5
chr5_+_175298487 0.05 ENST00000393745.3
 CPLX2
 complexin 2
chr16_+_3019246 0.05 ENST00000318782.8
ENST00000293978.8
 PAQR4
 progestin and adipoQ receptor family member IV
chrX_+_153237740 0.04 ENST00000369982.4
 TMEM187
 transmembrane protein 187
chr1_-_40105617 0.04 ENST00000372852.3
 HEYL
 hes-related family bHLH transcription factor with YRPW motif-like
chr20_-_60795296 0.04 ENST00000340177.5
 HRH3
 histamine receptor H3
chr20_-_44144249 0.04 ENST00000217428.6
 SPINT3
 serine peptidase inhibitor, Kunitz type, 3
chr16_+_5008290 0.04 ENST00000251170.7
 SEC14L5
 SEC14-like 5 (S. cerevisiae)
chr6_+_43603552 0.03 ENST00000372171.4
 MAD2L1BP
 MAD2L1 binding protein
chr1_+_171750776 0.03 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
 METTL13
 methyltransferase like 13
chr11_+_637246 0.03 ENST00000176183.5
 DRD4
 dopamine receptor D4
chr6_+_154360357 0.03 ENST00000330432.7
ENST00000360422.4
 OPRM1
 opioid receptor, mu 1
chr14_+_96039882 0.03 ENST00000556346.1
ENST00000553785.1
 RP11-1070N10.4
 RP11-1070N10.4
chr14_-_106478603 0.03 ENST00000390596.2
 IGHV4-4
 immunoglobulin heavy variable 4-4
chr4_+_158141806 0.02 ENST00000393815.2
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr5_+_175298674 0.02 ENST00000514150.1
 CPLX2
 complexin 2
chr4_+_158141843 0.02 ENST00000509417.1
ENST00000296526.7
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr14_-_51561784 0.02 ENST00000360392.4
 TRIM9
 tripartite motif containing 9
chr19_+_4769117 0.01 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
 MIR7-3HG
 MIR7-3 host gene (non-protein coding)
chr3_+_9745487 0.01 ENST00000383832.3
 CPNE9
 copine family member IX
chr4_+_8582287 0.01 ENST00000382487.4
 GPR78
 G protein-coupled receptor 78
chr14_-_74892805 0.01 ENST00000331628.3
ENST00000554953.1
 SYNDIG1L
 synapse differentiation inducing 1-like
chr1_+_210111534 0.01 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
 SYT14
 synaptotagmin XIV
chr20_-_60795316 0.01 ENST00000317393.6
 HRH3
 histamine receptor H3
chr12_+_119419294 0.01 ENST00000267260.4
 SRRM4
 serine/arginine repetitive matrix 4
chr3_-_131753830 0.01 ENST00000429747.1
 CPNE4
 copine IV
chr22_+_23054174 0.01 ENST00000390308.2
 IGLV3-21
 immunoglobulin lambda variable 3-21
chr10_+_99609996 0.01 ENST00000370602.1
 GOLGA7B
 golgin A7 family, member B
chr12_+_113796347 0.01 ENST00000545182.2
ENST00000280800.3
 PLBD2
 phospholipase B domain containing 2
chrX_-_47479246 0.01 ENST00000295987.7
ENST00000340666.4
 SYN1
 synapsin I
chr7_+_150748288 0.01 ENST00000490540.1
 ASIC3
 acid-sensing (proton-gated) ion channel 3
chr10_+_26505179 0.00 ENST00000376261.3
 GAD2
 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_151689259 0.00 ENST00000420342.1
ENST00000290583.4
 CELF3
 CUGBP, Elav-like family member 3
chr5_-_176037105 0.00 ENST00000303991.4
 GPRIN1
 G protein regulated inducer of neurite outgrowth 1
chr18_-_40857493 0.00 ENST00000255224.3
 SYT4
 synaptotagmin IV

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.3 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.2 GO:2000974 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.2 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0061110 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.2 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.0 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.2 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.8 GO:0045773 positive regulation of axon extension(GO:0045773)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.0 GO:0035939 microsatellite binding(GO:0035939)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling