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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for SIN3A_CHD1
Z-value: 2.14
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Transcription factors associated with SIN3A_CHD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIN3A | hg19_v2_chr15_-_75744014_75744087 | 0.82 | 1.4e-02 | Click! |
| CHD1 | hg19_v2_chr5_-_98262240_98262240 | -0.16 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIN3A_CHD1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_16964794 | 6.34 |
ENST00000357277.3 |
REPS2 |
RALBP1 associated Eps domain containing 2 |
| chrX_+_16964985 | 6.13 |
ENST00000303843.7 |
REPS2 |
RALBP1 associated Eps domain containing 2 |
| chr4_+_145567297 | 4.50 |
ENST00000434550.2 |
HHIP |
hedgehog interacting protein |
| chr10_-_79397479 | 4.34 |
ENST00000404771.3 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr4_+_145567173 | 3.94 |
ENST00000296575.3 |
HHIP |
hedgehog interacting protein |
| chr10_-_79397202 | 3.78 |
ENST00000372437.1 ENST00000372408.2 ENST00000372403.4 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr10_+_31608054 | 3.67 |
ENST00000320985.10 ENST00000361642.5 ENST00000560721.2 ENST00000558440.1 ENST00000424869.1 ENST00000542815.3 |
ZEB1 |
zinc finger E-box binding homeobox 1 |
| chr10_-_79397316 | 3.59 |
ENST00000372421.5 ENST00000457953.1 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr10_-_79397391 | 3.52 |
ENST00000286628.8 ENST00000406533.3 ENST00000354353.5 ENST00000404857.1 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr12_-_58131931 | 3.51 |
ENST00000547588.1 |
AGAP2 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 18.6 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.2 | 8.0 | GO:0045879 | negative regulation of smoothened signaling pathway(GO:0045879) |
| 0.6 | 5.9 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 1.3 | 5.2 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.2 | 5.0 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.5 | 4.8 | GO:0061551 | trigeminal ganglion development(GO:0061551) |
| 0.3 | 4.6 | GO:1901725 | regulation of histone deacetylase activity(GO:1901725) |
| 0.5 | 4.5 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.0 | 3.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 3.6 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.5 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 7.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 7.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 6.1 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 6.0 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 4.4 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.0 | 4.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 4.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 3.8 | GO:0031941 | filamentous actin(GO:0031941) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 18.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 1.2 | 8.3 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.1 | 7.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 6.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 5.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 5.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.5 | 4.8 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 4.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 4.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.9 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 7.9 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.2 | 6.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 6.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 6.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 5.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 4.3 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 4.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 6.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 5.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 4.9 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.1 | 3.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 3.4 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 3.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 3.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 3.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |