ISMARA results: SIX5_SMARCC2

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SIX5_SMARCC2_HCFC1

Z-value: 3.15

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Transcription factors associated with SIX5_SMARCC2_HCFC1

Gene Symbol	Gene ID	Gene Info
SIX5 Ensembl NCBI GeneCards UniProt	ENSG00000177045.6	SIX5
SMARCC2 Ensembl NCBI GeneCards UniProt	ENSG00000139613.7	SMARCC2
HCFC1 Ensembl NCBI GeneCards UniProt	ENSG00000172534.9	HCFC1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HCFC1	hg19_v2_chrX_-_153236819_153236978, hg19_v2_chrX_-_153236620_153236684, hg19_v2_chrX_-_153237258_153237295	-0.65	8.0e-02	Click!
SMARCC2	hg19_v2_chr12_-_56583243_56583293, hg19_v2_chr12_-_56583332_56583369	0.63	9.4e-02	Click!
SIX5	hg19_v2_chr19_-_46272462_46272562	0.60	1.2e-01	Click!

Activity profile of SIX5_SMARCC2_HCFC1 motif

Sorted Z-values of SIX5_SMARCC2_HCFC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX5_SMARCC2_HCFC1

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Promoter	Score	Transcript	Gene	Gene Info
chr20_+_62694834	5.99	ENST00000415602.1	TCEA2	transcription elongation factor A (SII), 2
chr20_+_62694590	5.32	ENST00000339217.4	TCEA2	transcription elongation factor A (SII), 2
chr20_+_62694461	5.25	ENST00000343484.5 ENST00000395053.3	TCEA2	transcription elongation factor A (SII), 2
chr1_+_47799542	3.32	ENST00000471289.2 ENST00000450808.2	CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr22_-_30162924	3.17	ENST00000344318.3 ENST00000397781.3	ZMAT5	zinc finger, matrin-type 5
chr16_-_3074231	3.11	ENST00000572355.1 ENST00000248089.3 ENST00000574980.1 ENST00000354679.3 ENST00000396916.1 ENST00000573842.1	HCFC1R1	host cell factor C1 regulator 1 (XPO1 dependent)
chr11_-_82782861	3.10	ENST00000524635.1 ENST00000526205.1 ENST00000527633.1 ENST00000533486.1 ENST00000533276.2	RAB30	RAB30, member RAS oncogene family
chr3_+_69788576	3.08	ENST00000352241.4 ENST00000448226.2	MITF	microphthalmia-associated transcription factor
chr16_-_3073933	3.04	ENST00000574151.1	HCFC1R1	host cell factor C1 regulator 1 (XPO1 dependent)
chr2_-_232645977	3.00	ENST00000409772.1	PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	16.5	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)
0.3	6.9	GO:0042424	catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1	6.5	GO:0048678	response to axon injury(GO:0048678)
0.1	6.0	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	5.7	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	5.6	GO:0035308	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.1	5.4	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.1	4.8	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.1	4.8	GO:2000144	positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1	4.3	GO:0043101	purine-containing compound salvage(GO:0043101)

Showing 1 to 10 of 244 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.4	GO:0008023	transcription elongation factor complex(GO:0008023)
0.2	7.0	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1	6.2	GO:0070469	respiratory chain(GO:0070469)
0.1	6.1	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.6	5.6	GO:0071986	Ragulator complex(GO:0071986)
0.6	4.9	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
1.2	4.8	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.7	4.3	GO:1902560	GMP reductase complex(GO:1902560)
0.2	4.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.1	4.0	GO:0005801	cis-Golgi network(GO:0005801)

Showing 1 to 10 of 132 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	35.2	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0	15.0	GO:0008270	zinc ion binding(GO:0008270)
0.2	10.7	GO:0070888	E-box binding(GO:0070888)
0.0	9.0	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	8.4	GO:0005525	GTP binding(GO:0005525)
0.8	6.8	GO:0016206	catechol O-methyltransferase activity(GO:0016206)
0.2	6.0	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.2	6.0	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	5.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	5.6	GO:0032947	protein complex scaffold(GO:0032947)

Showing 1 to 10 of 160 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.5	PID MYC PATHWAY	C-MYC pathway
0.2	6.8	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	5.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	4.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	3.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	3.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	2.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	2.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	2.1	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	2.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	39.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	9.7	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.1	6.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	4.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2	4.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.2	3.7	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.2	3.3	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	2.8	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	2.4	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	2.2	REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK

Showing 1 to 10 of 45 entries

Results for SIX5_SMARCC2_HCFC1

Z-value: 3.15

Motif logo

Transcription factors associated with SIX5_SMARCC2_HCFC1

Activity-expression correlation:

Activity profile of SIX5_SMARCC2_HCFC1 motif

Sorted Z-values of SIX5_SMARCC2_HCFC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX5_SMARCC2_HCFC1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: