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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SOX21

Z-value: 0.42

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SOX21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.734.0e-02Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_147286065 1.01 ENST00000318315.4
ENST00000515291.1
 C5orf46
 chromosome 5 open reading frame 46
chr1_+_221051699 0.42 ENST00000366903.6
 HLX
 H2.0-like homeobox
chr9_+_99690592 0.35 ENST00000354649.3
 NUTM2G
 NUT family member 2G
chr2_+_102759199 0.32 ENST00000409288.1
ENST00000410023.1
 IL1R1
 interleukin 1 receptor, type I
chr3_+_141103634 0.31 ENST00000507722.1
 ZBTB38
 zinc finger and BTB domain containing 38
chr5_-_95158644 0.30 ENST00000237858.6
 GLRX
 glutaredoxin (thioltransferase)
chr5_-_95158375 0.29 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX
 glutaredoxin (thioltransferase)
chr17_-_8702667 0.27 ENST00000329805.4
 MFSD6L
 major facilitator superfamily domain containing 6-like
chr5_-_61031495 0.25 ENST00000506550.1
ENST00000512882.2
 CTD-2170G1.2
 CTD-2170G1.2
chr3_-_37034702 0.20 ENST00000322716.5
 EPM2AIP1
 EPM2A (laforin) interacting protein 1
chr22_+_39353527 0.16 ENST00000249116.2
 APOBEC3A
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr19_+_42381337 0.16 ENST00000597454.1
ENST00000444740.2
 CD79A
 CD79a molecule, immunoglobulin-associated alpha
chr6_-_52926539 0.15 ENST00000350082.5
ENST00000356971.3
 ICK
 intestinal cell (MAK-like) kinase
chr5_+_134181755 0.14 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
 C5orf24
 chromosome 5 open reading frame 24
chr7_+_120702819 0.13 ENST00000423795.1
 CPED1
 cadherin-like and PC-esterase domain containing 1
chr12_-_10588539 0.13 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
 KLRC2
NKG2-E
 killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chr7_-_73133959 0.12 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A
 syntaxin 1A (brain)
chr1_-_112032284 0.11 ENST00000414219.1
 ADORA3
 adenosine A3 receptor
chr10_-_13276329 0.11 ENST00000378681.3
ENST00000463405.2
 UCMA
 upper zone of growth plate and cartilage matrix associated
chr6_+_131894284 0.10 ENST00000368087.3
ENST00000356962.2
 ARG1
 arginase 1
chr3_+_38537763 0.10 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
 EXOG
 endo/exonuclease (5'-3'), endonuclease G-like
chr3_+_38537960 0.09 ENST00000453767.1
 EXOG
 endo/exonuclease (5'-3'), endonuclease G-like
chrX_+_52927576 0.08 ENST00000416841.2
 FAM156B
 family with sequence similarity 156, member B
chr4_-_39034542 0.08 ENST00000344606.6
 TMEM156
 transmembrane protein 156
chr4_+_81951957 0.08 ENST00000282701.2
 BMP3
 bone morphogenetic protein 3
chrX_+_36053908 0.08 ENST00000378660.2
 CHDC2
 calponin homology domain containing 2
chr12_-_1058849 0.07 ENST00000358495.3
 RAD52
 RAD52 homolog (S. cerevisiae)
chr17_-_71410794 0.07 ENST00000424778.1
 SDK2
 sidekick cell adhesion molecule 2
chr3_+_37035263 0.07 ENST00000458205.2
ENST00000539477.1
 MLH1
 mutL homolog 1
chrX_-_71792477 0.06 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
 HDAC8
 histone deacetylase 8
chr3_-_186288097 0.06 ENST00000446782.1
 TBCCD1
 TBCC domain containing 1
chr3_+_155838337 0.06 ENST00000490337.1
ENST00000389636.5
 KCNAB1
 potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_66245341 0.06 ENST00000577985.1
 AMZ2
 archaelysin family metallopeptidase 2
chr12_-_7261772 0.06 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
 C1RL
 complement component 1, r subcomponent-like
chr3_-_164875850 0.06 ENST00000472120.1
 RP11-747D18.1
 RP11-747D18.1
chr19_-_21950332 0.06 ENST00000598026.1
 ZNF100
 zinc finger protein 100
chr11_+_5410607 0.06 ENST00000328611.3
 OR51M1
 olfactory receptor, family 51, subfamily M, member 1
chr11_-_62474803 0.05 ENST00000533982.1
ENST00000360796.5
 BSCL2
 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr19_+_42381173 0.05 ENST00000221972.3
 CD79A
 CD79a molecule, immunoglobulin-associated alpha
chr10_-_17243579 0.05 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
 TRDMT1
 tRNA aspartic acid methyltransferase 1
chr18_+_29769978 0.05 ENST00000269202.6
ENST00000581447.1
 MEP1B
 meprin A, beta
chr3_+_37035289 0.05 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
 MLH1
 mutL homolog 1
chr14_-_102771462 0.05 ENST00000522874.1
 MOK
 MOK protein kinase
chr5_+_175875349 0.04 ENST00000261942.6
 FAF2
 Fas associated factor family member 2
chr1_+_158901329 0.04 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
 PYHIN1
 pyrin and HIN domain family, member 1
chrX_+_2984874 0.04 ENST00000359361.2
 ARSF
 arylsulfatase F
chr14_-_92588013 0.04 ENST00000553514.1
ENST00000605997.1
 NDUFB1
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr11_+_114168085 0.04 ENST00000541754.1
 NNMT
 nicotinamide N-methyltransferase
chr8_-_19459993 0.04 ENST00000454498.2
ENST00000520003.1
 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_-_1058685 0.03 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
 RAD52
 RAD52 homolog (S. cerevisiae)
chr16_-_15149828 0.03 ENST00000566419.1
ENST00000568320.1
 NTAN1
 N-terminal asparagine amidase
chr5_-_179045199 0.03 ENST00000523921.1
 HNRNPH1
 heterogeneous nuclear ribonucleoprotein H1 (H)
chr9_-_70465758 0.03 ENST00000489273.1
 CBWD5
 COBW domain containing 5
chr7_-_14942944 0.03 ENST00000403951.2
 DGKB
 diacylglycerol kinase, beta 90kDa
chr7_-_86849883 0.03 ENST00000433078.1
 TMEM243
 transmembrane protein 243, mitochondrial
chr8_-_94029882 0.03 ENST00000520686.1
 TRIQK
 triple QxxK/R motif containing
chr20_+_43343886 0.03 ENST00000190983.4
 WISP2
 WNT1 inducible signaling pathway protein 2
chr6_+_140175987 0.03 ENST00000414038.1
ENST00000431609.1
 RP5-899B16.1
 RP5-899B16.1
chr4_-_177190364 0.03 ENST00000296525.3
 ASB5
 ankyrin repeat and SOCS box containing 5
chr10_-_12084770 0.03 ENST00000357604.5
 UPF2
 UPF2 regulator of nonsense transcripts homolog (yeast)
chrX_-_39186610 0.02 ENST00000429281.1
ENST00000448597.1
 RP11-265P11.2
 RP11-265P11.2
chr11_-_57479673 0.02 ENST00000337672.2
ENST00000431606.2
 MED19
 mediator complex subunit 19
chr1_+_199996733 0.02 ENST00000236914.3
 NR5A2
 nuclear receptor subfamily 5, group A, member 2
chr3_+_37034823 0.02 ENST00000231790.2
ENST00000456676.2
 MLH1
 mutL homolog 1
chr8_-_143961236 0.02 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
 CYP11B1
 cytochrome P450, family 11, subfamily B, polypeptide 1
chr5_+_140579162 0.02 ENST00000536699.1
ENST00000354757.3
 PCDHB11
 protocadherin beta 11
chr14_-_92588246 0.02 ENST00000329559.3
 NDUFB1
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr22_-_40929812 0.02 ENST00000422851.1
 MKL1
 megakaryoblastic leukemia (translocation) 1
chr12_+_123011776 0.01 ENST00000450485.2
ENST00000333479.7
 KNTC1
 kinetochore associated 1
chr1_+_151171012 0.01 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
 PIP5K1A
 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr3_-_155572164 0.01 ENST00000392845.3
ENST00000359479.3
 SLC33A1
 solute carrier family 33 (acetyl-CoA transporter), member 1
chr8_+_67687413 0.01 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
 SGK3
 serum/glucocorticoid regulated kinase family, member 3
chr14_+_21498360 0.01 ENST00000321760.6
ENST00000460647.2
ENST00000530140.2
ENST00000472458.1
 TPPP2
 tubulin polymerization-promoting protein family member 2
chr11_-_8285405 0.01 ENST00000335790.3
ENST00000534484.1
 LMO1
 LIM domain only 1 (rhombotin 1)
chr9_+_99691286 0.01 ENST00000372322.3
 NUTM2G
 NUT family member 2G
chr4_-_83931862 0.01 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
 LIN54
 lin-54 homolog (C. elegans)
chr12_-_10324716 0.01 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1
 oxidized low density lipoprotein (lectin-like) receptor 1
chr6_-_112575758 0.01 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
 LAMA4
 laminin, alpha 4
chrY_+_16634483 0.01 ENST00000382872.1
 NLGN4Y
 neuroligin 4, Y-linked
chr12_+_69742121 0.00 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
 LYZ
 lysozyme
chr19_+_16308659 0.00 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
 AP1M1
 adaptor-related protein complex 1, mu 1 subunit
chr20_+_56964253 0.00 ENST00000395802.3
 VAPB
 VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_+_217363559 0.00 ENST00000600880.1
ENST00000446558.1
 RPL37A
 ribosomal protein L37a
chr19_-_2783363 0.00 ENST00000221566.2
 SGTA
 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.1 0.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.6 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.6 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.0 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates