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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for SP1
Z-value: 1.99
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53773944_53773993 | 0.64 | 8.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_31697255 | 3.83 |
ENST00000436437.1 |
DDAH2 |
dimethylarginine dimethylaminohydrolase 2 |
| chr17_-_42277203 | 3.56 |
ENST00000587097.1 |
ATXN7L3 |
ataxin 7-like 3 |
| chr1_+_159141397 | 3.03 |
ENST00000368124.4 ENST00000368125.4 ENST00000416746.1 |
CADM3 |
cell adhesion molecule 3 |
| chr2_+_30369859 | 2.97 |
ENST00000402003.3 |
YPEL5 |
yippee-like 5 (Drosophila) |
| chr6_-_31697563 | 2.93 |
ENST00000375789.2 ENST00000416410.1 |
DDAH2 |
dimethylarginine dimethylaminohydrolase 2 |
| chr10_-_81205373 | 2.92 |
ENST00000372336.3 |
ZCCHC24 |
zinc finger, CCHC domain containing 24 |
| chr19_+_11457232 | 2.89 |
ENST00000587531.1 |
CCDC159 |
coiled-coil domain containing 159 |
| chr17_-_42276574 | 2.46 |
ENST00000589805.1 |
ATXN7L3 |
ataxin 7-like 3 |
| chr2_+_30369807 | 2.45 |
ENST00000379520.3 ENST00000379519.3 ENST00000261353.4 |
YPEL5 |
yippee-like 5 (Drosophila) |
| chr17_-_66453562 | 2.35 |
ENST00000262139.5 ENST00000546360.1 |
WIPI1 |
WD repeat domain, phosphoinositide interacting 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.0 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.1 | 7.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.8 | 7.0 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 6.9 | GO:1902807 | negative regulation of cell cycle G1/S phase transition(GO:1902807) |
| 0.4 | 5.7 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.1 | 5.4 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.3 | 4.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 4.7 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
| 0.2 | 4.7 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.1 | 4.5 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 11.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 9.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 9.6 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.5 | 8.5 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 7.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 7.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 6.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.5 | 6.7 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 6.6 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 14.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 12.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.4 | 9.7 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 9.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 6.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 6.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 6.0 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 6.0 | GO:0004407 | histone deacetylase activity(GO:0004407) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 10.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 7.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 7.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.8 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 5.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 4.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 9.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 6.4 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 6.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 6.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 6.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 6.0 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 5.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 4.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |