Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for SPIC
Z-value: 1.51
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Transcription factors associated with SPIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIC | hg19_v2_chr12_+_101869096_101869199 | 0.31 | 4.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_68678739 | 2.73 |
ENST00000264012.4 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
| chr16_+_68678892 | 2.64 |
ENST00000429102.2 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
| chr12_-_51785182 | 1.70 |
ENST00000356317.3 ENST00000603188.1 ENST00000604847.1 ENST00000604506.1 |
GALNT6 |
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) |
| chr2_-_113594279 | 1.65 |
ENST00000416750.1 ENST00000418817.1 ENST00000263341.2 |
IL1B |
interleukin 1, beta |
| chr10_-_99161033 | 1.63 |
ENST00000315563.6 ENST00000370992.4 ENST00000414986.1 |
RRP12 |
ribosomal RNA processing 12 homolog (S. cerevisiae) |
| chr15_+_90744533 | 1.58 |
ENST00000411539.2 |
SEMA4B |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
| chr1_-_175161890 | 1.58 |
ENST00000545251.2 ENST00000423313.1 |
KIAA0040 |
KIAA0040 |
| chr2_+_182321925 | 1.57 |
ENST00000339307.4 ENST00000397033.2 |
ITGA4 |
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| chr4_-_89152474 | 1.57 |
ENST00000515655.1 |
ABCG2 |
ATP-binding cassette, sub-family G (WHITE), member 2 |
| chr6_-_11779403 | 1.56 |
ENST00000414691.3 |
ADTRP |
androgen-dependent TFPI-regulating protein |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0032771 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 0.7 | 4.2 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.7 | 4.0 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.1 | 2.4 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.3 | 2.1 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.0 | 2.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 2.0 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 2.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 1.9 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 1.7 | GO:0016266 | O-glycan processing(GO:0016266) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.6 | 4.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 3.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.3 | 2.5 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 2.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 2.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.5 | 2.1 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 0.1 | 2.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 2.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 2.5 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 2.5 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.2 | 2.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 2.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 1.8 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 1.7 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.1 | 1.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 1.6 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.0 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.4 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 1.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 2.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 2.4 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 2.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 2.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.0 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 2.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |