ISMARA results: SREBF2

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SREBF2

Z-value: 0.45

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Transcription factors associated with SREBF2

Gene Symbol	Gene ID	Gene Info
SREBF2 Ensembl NCBI GeneCards UniProt	ENSG00000198911.7	SREBF2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SREBF2	hg19_v2_chr22_+_42229100_42229146	-0.04	9.2e-01	Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Promoter	Score	Transcript	Gene	Gene Info
chr5_-_149535421	0.69	ENST00000261799.4	PDGFRB	platelet-derived growth factor receptor, beta polypeptide
chr15_+_33010175	0.65	ENST00000300177.4 ENST00000560677.1 ENST00000560830.1	GREM1	gremlin 1, DAN family BMP antagonist
chr19_-_11308190	0.37	ENST00000586659.1 ENST00000592903.1 ENST00000589359.1 ENST00000588724.1 ENST00000432929.2	KANK2	KN motif and ankyrin repeat domains 2
chr6_+_151561085	0.29	ENST00000402676.2	AKAP12	A kinase (PRKA) anchor protein 12
chr20_+_33464238	0.25	ENST00000360596.2	ACSS2	acyl-CoA synthetase short-chain family member 2
chr5_-_39425068	0.25	ENST00000515700.1 ENST00000339788.6	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr20_+_33464407	0.22	ENST00000253382.5	ACSS2	acyl-CoA synthetase short-chain family member 2
chr17_-_15168624	0.22	ENST00000312280.3 ENST00000494511.1 ENST00000580584.1	PMP22	peripheral myelin protein 22
chr12_-_91505608	0.16	ENST00000266718.4	LUM	lumican
chr8_+_26435359	0.15	ENST00000311151.5	DPYSL2	dihydropyrimidinase-like 2

Showing 1 to 10 of 75 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:1900158	negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2	0.7	GO:0035441	cell migration involved in vasculogenesis(GO:0035441) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1	0.5	GO:0019427	acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.1	0.4	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1	0.3	GO:0035026	leading edge cell differentiation(GO:0035026)
0.0	0.3	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.3	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.2	GO:0046618	drug export(GO:0046618)
0.0	0.2	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)

Showing 1 to 10 of 14 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	GO:0035976	AP1 complex(GO:0035976)
0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	GO:0019008	molybdopterin synthase complex(GO:0019008)

Showing 1 to 5 of 5 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.7	GO:0016015	morphogen activity(GO:0016015)
0.1	0.5	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.3	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.3	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	0.2	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation

Showing 1 to 2 of 2 entries

Results for SREBF2

Z-value: 0.45

Motif logo

Transcription factors associated with SREBF2

Activity-expression correlation:

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: