Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
Navigation
Downloads
Results for SRF
Z-value: 1.31
Motif logo
Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43139037_43139094 | -0.23 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_35169885 | 4.51 |
ENST00000279022.2 ENST00000346786.2 |
MYL9 |
myosin, light chain 9, regulatory |
| chr8_+_97597148 | 3.22 |
ENST00000521590.1 |
SDC2 |
syndecan 2 |
| chr5_+_92919043 | 2.89 |
ENST00000327111.3 |
NR2F1 |
nuclear receptor subfamily 2, group F, member 1 |
| chr10_-_64576105 | 2.67 |
ENST00000242480.3 ENST00000411732.1 |
EGR2 |
early growth response 2 |
| chr10_+_31610064 | 1.99 |
ENST00000446923.2 ENST00000559476.1 |
ZEB1 |
zinc finger E-box binding homeobox 1 |
| chr19_+_2476116 | 1.64 |
ENST00000215631.4 ENST00000587345.1 |
GADD45B |
growth arrest and DNA-damage-inducible, beta |
| chr5_+_40679584 | 1.48 |
ENST00000302472.3 |
PTGER4 |
prostaglandin E receptor 4 (subtype EP4) |
| chr9_-_79520989 | 1.46 |
ENST00000376713.3 ENST00000376718.3 ENST00000428286.1 |
PRUNE2 |
prune homolog 2 (Drosophila) |
| chr5_-_111093167 | 1.44 |
ENST00000446294.2 ENST00000419114.2 |
NREP |
neuronal regeneration related protein |
| chr9_+_36136700 | 1.40 |
ENST00000396613.3 ENST00000377959.1 ENST00000377960.4 |
GLIPR2 |
GLI pathogenesis-related 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.5 | 3.2 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 2.9 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.1 | 2.8 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.9 | 2.7 | GO:0035284 | rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.5 | 2.3 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.2 | 2.0 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.3 | 1.7 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.5 | 1.5 | GO:2000417 | negative regulation of eosinophil migration(GO:2000417) |
| 0.2 | 1.4 | GO:0006848 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 3.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 2.6 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.7 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.0 | 0.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.6 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 3.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.4 | 2.9 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 2.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 2.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 2.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 1.5 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.4 | 1.4 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.3 | 1.3 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.1 | 1.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.3 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 3.2 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 2.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.7 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 3.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 2.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 2.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.5 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.1 | 1.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.9 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |