ISMARA results: STAT1_STAT3

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for STAT1_STAT3_BCL6

Z-value: 1.37

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Transcription factors associated with STAT1_STAT3_BCL6

Gene Symbol	Gene ID	Gene Info
STAT1 Ensembl NCBI GeneCards UniProt	ENSG00000115415.14	STAT1
STAT3 Ensembl NCBI GeneCards UniProt	ENSG00000168610.10	STAT3
BCL6 Ensembl NCBI GeneCards UniProt	ENSG00000113916.13	BCL6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BCL6	hg19_v2_chr3_-_187454281_187454357	0.83	1.0e-02	Click!
STAT1	hg19_v2_chr2_-_191878874_191878976	0.76	2.9e-02	Click!
STAT3	hg19_v2_chr17_-_40540586_40540600	0.66	7.7e-02	Click!

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr14_-_30396948	2.99	ENST00000331968.5	PRKD1	protein kinase D1
chr8_-_120651020	2.90	ENST00000522826.1 ENST00000520066.1 ENST00000259486.6 ENST00000075322.6	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr1_+_163038565	2.81	ENST00000421743.2	RGS4	regulator of G-protein signaling 4
chr12_+_53443963	2.76	ENST00000546602.1 ENST00000552570.1 ENST00000549700.1	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr12_-_91539918	2.46	ENST00000548218.1	DCN	decorin
chr12_+_53443680	2.45	ENST00000314250.6 ENST00000451358.1	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_163039143	2.42	ENST00000531057.1 ENST00000527809.1 ENST00000367908.4	RGS4	regulator of G-protein signaling 4
chr3_-_93692781	2.22	ENST00000394236.3	PROS1	protein S (alpha)
chr5_-_111092873	2.14	ENST00000509025.1 ENST00000515855.1	NREP	neuronal regeneration related protein
chr2_-_190044480	2.06	ENST00000374866.3	COL5A2	collagen, type V, alpha 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.7	4.4	GO:1902847	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2	3.7	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.4	3.0	GO:0089700	protein kinase D signaling(GO:0089700)
0.2	2.5	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3	2.3	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.7	2.1	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.6	1.9	GO:0001544	initiation of primordial ovarian follicle growth(GO:0001544)
0.1	1.9	GO:0048251	elastic fiber assembly(GO:0048251)
0.3	1.8	GO:0010756	positive regulation of plasminogen activation(GO:0010756)

Showing 1 to 10 of 169 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.4	GO:0097418	neurofibrillary tangle(GO:0097418)
0.1	3.0	GO:0000421	autophagosome membrane(GO:0000421)
0.2	2.5	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.7	2.1	GO:0005588	collagen type V trimer(GO:0005588)
0.3	1.8	GO:0001652	granular component(GO:0001652)
0.0	1.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	1.5	GO:0071953	elastic fiber(GO:0071953)
0.0	1.4	GO:0005884	actin filament(GO:0005884)
0.1	1.3	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	1.3	GO:0031941	filamentous actin(GO:0031941)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.3	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.2	4.4	GO:0051787	misfolded protein binding(GO:0051787)
1.0	3.9	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	2.6	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	2.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	2.0	GO:0004697	protein kinase C activity(GO:0004697)
0.0	1.9	GO:0001221	transcription cofactor binding(GO:0001221)
0.0	1.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	1.6	GO:0004707	MAP kinase activity(GO:0004707)
0.1	1.4	GO:0035374	chondroitin sulfate binding(GO:0035374)

Showing 1 to 10 of 109 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	3.0	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	2.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	2.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	2.0	NABA COLLAGENS	Genes encoding collagen proteins
0.1	1.9	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	1.4	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	1.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	1.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	3.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	2.8	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	2.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	2.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	2.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	2.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	1.9	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	1.7	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	1.6	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Showing 1 to 10 of 27 entries

Results for STAT1_STAT3_BCL6

Z-value: 1.37

Motif logo

Transcription factors associated with STAT1_STAT3_BCL6

Activity-expression correlation:

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: