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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for STAT5B
Z-value: 1.32
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Transcription factors associated with STAT5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5B | hg19_v2_chr17_-_40428359_40428462 | -0.66 | 7.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5B
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_154250989 | 1.70 |
ENST00000360256.4 |
F8 |
coagulation factor VIII, procoagulant component |
| chr5_+_178450753 | 1.58 |
ENST00000444149.2 ENST00000519896.1 ENST00000522442.1 |
ZNF879 |
zinc finger protein 879 |
| chr5_-_111093081 | 1.56 |
ENST00000453526.2 ENST00000509427.1 |
NREP |
neuronal regeneration related protein |
| chr5_-_111092873 | 1.47 |
ENST00000509025.1 ENST00000515855.1 |
NREP |
neuronal regeneration related protein |
| chr19_+_35168633 | 1.43 |
ENST00000505365.2 |
ZNF302 |
zinc finger protein 302 |
| chr19_+_35168567 | 1.37 |
ENST00000457781.2 ENST00000505163.1 ENST00000505242.1 ENST00000423823.2 ENST00000507959.1 ENST00000446502.2 |
ZNF302 |
zinc finger protein 302 |
| chr19_+_35168547 | 1.36 |
ENST00000502743.1 ENST00000509528.1 ENST00000506901.1 |
ZNF302 |
zinc finger protein 302 |
| chr19_-_44860820 | 1.34 |
ENST00000354340.4 ENST00000337401.4 ENST00000587909.1 |
ZNF112 |
zinc finger protein 112 |
| chr5_-_111092930 | 1.30 |
ENST00000257435.7 |
NREP |
neuronal regeneration related protein |
| chr5_-_111093340 | 1.27 |
ENST00000508870.1 |
NREP |
neuronal regeneration related protein |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 1.4 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.1 | 1.0 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.0 | 0.6 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 0.5 | GO:0048850 | hypophysis morphogenesis(GO:0048850) |
| 0.1 | 0.5 | GO:0090521 | regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521) |
| 0.0 | 0.5 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.0 | 0.5 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.5 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.3 | 1.1 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 0.6 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.6 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 0.5 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.5 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.4 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 0.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 1.4 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.0 | 1.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.8 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.5 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 0.5 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.5 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.0 | 0.5 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.4 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.0 | 0.4 | GO:0005549 | odorant binding(GO:0005549) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 1.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.5 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.4 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 0.4 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |