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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TAF1
Z-value: 2.84
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Transcription factors associated with TAF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg19_v2_chrX_+_70586082_70586114 | 0.95 | 3.7e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_102104980 | 3.18 |
ENST00000545560.2 |
ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
| chr13_+_102104952 | 2.84 |
ENST00000376180.3 |
ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
| chr14_-_30396802 | 2.44 |
ENST00000415220.2 |
PRKD1 |
protein kinase D1 |
| chr3_+_45071622 | 2.21 |
ENST00000428034.1 |
CLEC3B |
C-type lectin domain family 3, member B |
| chr5_-_139944196 | 2.18 |
ENST00000357560.4 |
APBB3 |
amyloid beta (A4) precursor protein-binding, family B, member 3 |
| chr2_+_120770581 | 2.14 |
ENST00000263713.5 |
EPB41L5 |
erythrocyte membrane protein band 4.1 like 5 |
| chr5_-_139943830 | 2.03 |
ENST00000412920.3 ENST00000511201.2 ENST00000356738.2 ENST00000354402.5 ENST00000358580.5 ENST00000508496.2 |
APBB3 |
amyloid beta (A4) precursor protein-binding, family B, member 3 |
| chrX_+_16964985 | 2.00 |
ENST00000303843.7 |
REPS2 |
RALBP1 associated Eps domain containing 2 |
| chr10_-_79397479 | 1.81 |
ENST00000404771.3 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr9_-_123342415 | 1.78 |
ENST00000349780.4 ENST00000360190.4 ENST00000360822.3 ENST00000359309.3 |
CDK5RAP2 |
CDK5 regulatory subunit associated protein 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.3 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.6 | 5.1 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.6 | 4.0 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.9 | 3.7 | GO:0090301 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.1 | 3.7 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.0 | 3.6 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 3.4 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 3.1 | GO:0006333 | chromatin assembly or disassembly(GO:0006333) |
| 0.3 | 3.0 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.3 | 2.8 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0005901 | caveola(GO:0005901) |
| 0.3 | 5.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 3.6 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 3.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 3.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 2.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.4 | 2.2 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 2.1 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 2.1 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 2.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.3 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 5.8 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 5.1 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 3.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 3.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 3.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 3.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.2 | 3.3 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 3.3 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 3.2 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.3 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 4.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 3.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 3.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 2.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 2.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 5.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 4.6 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 4.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 4.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 3.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.6 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.0 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 2.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |