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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TCF3_MYOG
Z-value: 1.52
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Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYOG | hg19_v2_chr1_-_203055129_203055164 | -0.62 | 1.0e-01 | Click! |
| TCF3 | hg19_v2_chr19_-_1652575_1652621 | -0.34 | 4.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_89990431 | 2.91 |
ENST00000330947.2 ENST00000358200.4 |
LRRC8B |
leucine rich repeat containing 8 family, member B |
| chrX_-_107018969 | 2.75 |
ENST00000372383.4 |
TSC22D3 |
TSC22 domain family, member 3 |
| chr14_-_92413353 | 2.70 |
ENST00000556154.1 |
FBLN5 |
fibulin 5 |
| chrX_+_86772787 | 2.66 |
ENST00000373114.4 |
KLHL4 |
kelch-like family member 4 |
| chr3_+_69788576 | 2.59 |
ENST00000352241.4 ENST00000448226.2 |
MITF |
microphthalmia-associated transcription factor |
| chr14_-_92414055 | 2.47 |
ENST00000342058.4 |
FBLN5 |
fibulin 5 |
| chr2_+_33359646 | 2.41 |
ENST00000390003.4 ENST00000418533.2 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chr2_+_33359687 | 2.37 |
ENST00000402934.1 ENST00000404525.1 ENST00000407925.1 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chrX_+_86772707 | 2.35 |
ENST00000373119.4 |
KLHL4 |
kelch-like family member 4 |
| chr17_-_19648683 | 2.26 |
ENST00000573368.1 ENST00000457500.2 |
ALDH3A1 |
aldehyde dehydrogenase 3 family, member A1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.2 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.7 | 7.1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 4.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.4 | 3.9 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.0 | 3.8 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.3 | 3.2 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.3 | 3.1 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 3.1 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.2 | 2.9 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.2 | 2.8 | GO:0006527 | arginine catabolic process(GO:0006527) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.7 | 7.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 5.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 4.7 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 3.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 3.2 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 3.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 3.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.0 | GO:0031672 | A band(GO:0031672) |
| 1.0 | 2.9 | GO:0032173 | septin ring(GO:0005940) septin collar(GO:0032173) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 5.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.9 | 4.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 4.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 3.9 | GO:0043426 | MRF binding(GO:0043426) |
| 0.4 | 3.4 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.4 | 3.2 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 2.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.4 | 2.8 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.1 | 2.8 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 2.8 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 2.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.9 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 1.5 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 1.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.4 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 3.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.7 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 2.5 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 1.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.3 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 1.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |