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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TFAP2C
Z-value: 2.61
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Transcription factors associated with TFAP2C
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2C | hg19_v2_chr20_+_55205825_55205938 | 0.64 | 8.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2C
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_27286897 | 4.07 |
ENST00000320567.5 |
C1orf172 |
chromosome 1 open reading frame 172 |
| chr19_-_35992780 | 3.97 |
ENST00000593342.1 ENST00000601650.1 ENST00000408915.2 |
DMKN |
dermokine |
| chr19_-_51522955 | 3.92 |
ENST00000358789.3 |
KLK10 |
kallikrein-related peptidase 10 |
| chr13_-_20806440 | 3.79 |
ENST00000400066.3 ENST00000400065.3 ENST00000356192.6 |
GJB6 |
gap junction protein, beta 6, 30kDa |
| chr1_+_44401479 | 3.73 |
ENST00000438616.3 |
ARTN |
artemin |
| chr18_-_28622774 | 3.66 |
ENST00000434452.1 |
DSC3 |
desmocollin 3 |
| chr16_+_68679193 | 3.54 |
ENST00000581171.1 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
| chr15_+_41136586 | 3.38 |
ENST00000431806.1 |
SPINT1 |
serine peptidase inhibitor, Kunitz type 1 |
| chr16_+_22825475 | 3.35 |
ENST00000261374.3 |
HS3ST2 |
heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| chr18_-_28681950 | 3.34 |
ENST00000251081.6 |
DSC2 |
desmocollin 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.6 | GO:0070268 | cornification(GO:0070268) |
| 1.5 | 9.1 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.8 | 8.3 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 1.2 | 7.1 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.0 | 5.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 4.7 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.4 | 4.6 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.3 | 4.1 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 4.1 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
| 1.0 | 4.0 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.2 | GO:0030057 | desmosome(GO:0030057) |
| 1.3 | 9.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 7.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 6.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 5.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 3.7 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 3.6 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 3.6 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.2 | 3.5 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.4 | 3.2 | GO:0061689 | tricellular tight junction(GO:0061689) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 6.1 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 6.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.7 | 5.9 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 5.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 5.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 5.1 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 4.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 4.3 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 6.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 5.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 4.1 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.1 | 4.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 3.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 5.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 5.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 4.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.2 | 4.1 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 4.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 4.0 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 3.6 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 3.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |