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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TWIST1_SNAI1
Z-value: 2.12
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Transcription factors associated with TWIST1_SNAI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TWIST1 | hg19_v2_chr7_-_19157248_19157295 | -0.94 | 4.4e-04 | Click! |
| SNAI1 | hg19_v2_chr20_+_48599506_48599536 | 0.48 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TWIST1_SNAI1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_160990886 | 5.37 |
ENST00000537746.1 |
F11R |
F11 receptor |
| chr1_+_35247859 | 5.16 |
ENST00000373362.3 |
GJB3 |
gap junction protein, beta 3, 31kDa |
| chr2_+_47596287 | 4.60 |
ENST00000263735.4 |
EPCAM |
epithelial cell adhesion molecule |
| chr19_-_49565254 | 3.94 |
ENST00000593537.1 |
NTF4 |
neurotrophin 4 |
| chr3_-_111314230 | 3.88 |
ENST00000317012.4 |
ZBED2 |
zinc finger, BED-type containing 2 |
| chr16_+_68679193 | 3.81 |
ENST00000581171.1 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
| chr4_+_40198527 | 3.78 |
ENST00000381799.5 |
RHOH |
ras homolog family member H |
| chr1_+_60280458 | 3.68 |
ENST00000455990.1 ENST00000371208.3 |
HOOK1 |
hook microtubule-tethering protein 1 |
| chr19_+_35609380 | 3.67 |
ENST00000604621.1 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr17_-_39677971 | 3.49 |
ENST00000393976.2 |
KRT15 |
keratin 15 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | GO:0031424 | keratinization(GO:0031424) |
| 2.5 | 7.5 | GO:0032773 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 1.5 | 6.1 | GO:0007402 | ganglion mother cell fate determination(GO:0007402) |
| 0.3 | 5.4 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.2 | 5.2 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.1 | 4.7 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.1 | 4.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 4.6 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.7 | 4.4 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.5 | 4.4 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 11.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 5.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 5.3 | GO:0005769 | early endosome(GO:0005769) |
| 0.6 | 5.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 4.9 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 4.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 4.4 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 4.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.7 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 7.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 6.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.0 | 6.1 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.1 | 5.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.2 | 5.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.4 | 5.3 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.2 | 4.9 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.5 | 4.4 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 3.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 5.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 2.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 7.8 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 7.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 7.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 5.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 4.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 3.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.2 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 2.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 2.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |