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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for WRNIP1
Z-value: 2.15
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Transcription factors associated with WRNIP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| WRNIP1 | hg19_v2_chr6_+_2765595_2765797 | 0.69 | 6.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of WRNIP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_36004543 | 7.30 |
ENST00000339686.3 ENST00000447113.2 ENST00000440396.1 |
DMKN |
dermokine |
| chr19_-_51456344 | 6.46 |
ENST00000336334.3 ENST00000593428.1 |
KLK5 |
kallikrein-related peptidase 5 |
| chr1_-_153588334 | 6.09 |
ENST00000476873.1 |
S100A14 |
S100 calcium binding protein A14 |
| chr19_-_51504852 | 4.97 |
ENST00000391806.2 ENST00000347619.4 ENST00000291726.7 ENST00000320838.5 |
KLK8 |
kallikrein-related peptidase 8 |
| chr19_-_51456321 | 4.96 |
ENST00000391809.2 |
KLK5 |
kallikrein-related peptidase 5 |
| chr2_+_102608306 | 4.69 |
ENST00000332549.3 |
IL1R2 |
interleukin 1 receptor, type II |
| chr7_+_145813453 | 4.67 |
ENST00000361727.3 |
CNTNAP2 |
contactin associated protein-like 2 |
| chr1_-_153588765 | 4.47 |
ENST00000368701.1 ENST00000344616.2 |
S100A14 |
S100 calcium binding protein A14 |
| chr8_-_41166953 | 4.32 |
ENST00000220772.3 |
SFRP1 |
secreted frizzled-related protein 1 |
| chr19_-_51504411 | 4.03 |
ENST00000593490.1 |
KLK8 |
kallikrein-related peptidase 8 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.8 | GO:0070268 | cornification(GO:0070268) |
| 3.2 | 19.4 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 2.8 | 16.8 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.5 | 15.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.5 | 13.1 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 1.1 | 9.2 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.5 | 9.2 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.2 | 9.2 | GO:0043616 | keratinocyte proliferation(GO:0043616) |
| 0.0 | 8.3 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 1.4 | 8.2 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 20.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.2 | 19.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.4 | 15.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 15.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.6 | 14.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 12.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 11.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.3 | 10.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 10.4 | GO:0034706 | sodium channel complex(GO:0034706) |
| 1.3 | 10.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 54.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 13.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.9 | 13.0 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 12.7 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.2 | 9.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 9.3 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.6 | 8.9 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 7.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 7.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 1.3 | 6.3 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 15.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 14.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 12.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.5 | 11.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 9.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 8.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 8.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 6.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 16.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 11.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 10.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 9.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 9.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 8.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.3 | 7.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 7.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 6.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |