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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for XBP1
Z-value: 1.12
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg19_v2_chr22_-_29196030_29196121, hg19_v2_chr22_-_29196546_29196585 | -0.14 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_94023873 | 5.94 |
ENST00000297268.6 |
COL1A2 |
collagen, type I, alpha 2 |
| chr5_+_119799927 | 2.26 |
ENST00000407149.2 ENST00000379551.2 |
PRR16 |
proline rich 16 |
| chr5_-_9546180 | 2.16 |
ENST00000382496.5 |
SEMA5A |
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| chr5_-_121413974 | 1.34 |
ENST00000231004.4 |
LOX |
lysyl oxidase |
| chr22_+_38864041 | 1.24 |
ENST00000216014.4 ENST00000409006.3 |
KDELR3 |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 |
| chr10_+_89419370 | 1.21 |
ENST00000361175.4 ENST00000456849.1 |
PAPSS2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| chr8_+_104384616 | 1.05 |
ENST00000520337.1 |
CTHRC1 |
collagen triple helix repeat containing 1 |
| chr7_-_19157248 | 0.99 |
ENST00000242261.5 |
TWIST1 |
twist family bHLH transcription factor 1 |
| chr14_+_100259666 | 0.85 |
ENST00000262233.6 ENST00000334192.4 |
EML1 |
echinoderm microtubule associated protein like 1 |
| chr5_+_9546306 | 0.84 |
ENST00000508179.1 |
SNHG18 |
small nucleolar RNA host gene 18 (non-protein coding) |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.9 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.1 | 2.3 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.2 | 2.2 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.2 | 1.3 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.1 | 1.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 1.2 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.1 | 1.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 1.1 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.3 | 1.0 | GO:2000276 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.1 | 1.0 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.9 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 2.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.1 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.2 | 0.9 | GO:0043293 | apoptosome(GO:0043293) |
| 0.1 | 0.8 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 0.7 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 0.6 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 0.6 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.4 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.5 | 2.2 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.0 | 1.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.3 | 1.3 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.4 | 1.2 | GO:0004020 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.1 | 1.2 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 1.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 1.0 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.2 | 0.9 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 2.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.9 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |