ISMARA results: YBX1_FOS_NFYC_NFYA_NFYB

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.34

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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Gene Symbol	Gene ID	Gene Info
YBX1 Ensembl NCBI GeneCards UniProt	ENSG00000065978.13	YBX1
FOS Ensembl NCBI GeneCards UniProt	ENSG00000170345.5	FOS
NFYC Ensembl NCBI GeneCards UniProt	ENSG00000066136.15	NFYC
NFYA Ensembl NCBI GeneCards UniProt	ENSG00000001167.10	NFYA
NFYB Ensembl NCBI GeneCards UniProt	ENSG00000120837.3	NFYB
CEBPZ Ensembl NCBI GeneCards UniProt	ENSG00000115816.9	CEBPZ

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFYC	hg19_v2_chr1_+_41204506_41204541	0.85	8.1e-03	Click!
NFYA	hg19_v2_chr6_+_41040678_41040722	0.80	1.8e-02	Click!
FOS	hg19_v2_chr14_+_75745477_75745680	-0.65	7.9e-02	Click!
YBX1	hg19_v2_chr1_+_43148059_43148111	0.55	1.6e-01	Click!
NFYB	hg19_v2_chr12_-_104531785_104531812	0.48	2.3e-01	Click!
CEBPZ	hg19_v2_chr2_-_37458749_37458856	-0.41	3.1e-01	Click!

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Promoter	Score	Transcript	Gene	Gene Info
chr4_-_2264015	5.50	ENST00000337190.2	MXD4	MAX dimerization protein 4
chr1_+_163039143	4.54	ENST00000531057.1 ENST00000527809.1 ENST00000367908.4	RGS4	regulator of G-protein signaling 4
chr1_+_163038565	4.29	ENST00000421743.2	RGS4	regulator of G-protein signaling 4
chr6_-_167040731	4.25	ENST00000265678.4	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_145438469	4.23	ENST00000369317.4	TXNIP	thioredoxin interacting protein
chr12_-_6665200	3.87	ENST00000336604.4 ENST00000396840.2 ENST00000356896.4	IFFO1	intermediate filament family orphan 1
chr14_-_52535712	3.31	ENST00000216286.5 ENST00000541773.1	NID2	nidogen 2 (osteonidogen)
chr14_-_74551096	3.21	ENST00000350259.4	ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr1_+_213123915	2.99	ENST00000366968.4 ENST00000490792.1	VASH2	vasohibin 2
chr1_-_46598284	2.98	ENST00000423209.1 ENST00000262741.5	PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.1	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.2	9.2	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1	8.2	GO:0015701	bicarbonate transport(GO:0015701)
0.2	7.0	GO:0071711	basement membrane organization(GO:0071711)
0.2	5.9	GO:2001275	positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.4	5.5	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.7	5.5	GO:0021678	third ventricle development(GO:0021678)
1.6	4.8	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.1	4.8	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.1	4.7	GO:0045026	plasma membrane fusion(GO:0045026)

Showing 1 to 10 of 580 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	15.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	13.7	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.2	9.9	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	8.0	GO:0043197	dendritic spine(GO:0043197)
0.1	7.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.3	6.5	GO:0097386	glial cell projection(GO:0097386)
0.2	6.0	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	5.4	GO:0005739	mitochondrion(GO:0005739)
0.2	5.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.3	4.8	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Showing 1 to 10 of 244 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.1	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.3	10.3	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	10.2	GO:0017124	SH3 domain binding(GO:0017124)
0.3	8.3	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.3	7.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	6.9	GO:0030695	GTPase regulator activity(GO:0030695)
0.1	6.2	GO:0019003	GDP binding(GO:0019003)
0.2	5.9	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	5.9	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.5	5.8	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)

Showing 1 to 10 of 386 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.3	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.1	8.1	PID PLK1 PATHWAY	PLK1 signaling events
0.1	7.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	6.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	5.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	4.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	4.0	PID E2F PATHWAY	E2F transcription factor network
0.1	3.9	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	3.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	3.5	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway

Showing 1 to 10 of 69 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.7	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	9.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.3	8.0	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.3	7.9	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	7.8	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	6.5	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.2	6.3	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1	6.3	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1	6.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	5.9	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis

Showing 1 to 10 of 112 entries

Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.34

Motif logo

Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Activity-expression correlation:

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: