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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ZBTB33_CHD2
Z-value: 2.04
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg19_v2_chr15_+_93447675_93447703 | 0.89 | 3.1e-03 | Click! |
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | -0.50 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_48937982 | 2.08 |
ENST00000316623.5 |
FBN1 |
fibrillin 1 |
| chr3_+_42642106 | 1.64 |
ENST00000232978.8 |
NKTR |
natural killer-tumor recognition sequence |
| chr5_+_169010638 | 1.45 |
ENST00000265295.4 ENST00000506574.1 ENST00000515224.1 ENST00000508247.1 ENST00000513941.1 |
SPDL1 |
spindle apparatus coiled-coil protein 1 |
| chr2_-_20101701 | 1.18 |
ENST00000402414.1 ENST00000333610.3 |
TTC32 |
tetratricopeptide repeat domain 32 |
| chr8_+_16884740 | 1.15 |
ENST00000318063.5 |
MICU3 |
mitochondrial calcium uptake family, member 3 |
| chr2_-_20101385 | 1.13 |
ENST00000431392.1 |
TTC32 |
tetratricopeptide repeat domain 32 |
| chr14_-_92413727 | 1.13 |
ENST00000267620.10 |
FBLN5 |
fibulin 5 |
| chr13_+_115047097 | 1.12 |
ENST00000351487.5 |
UPF3A |
UPF3 regulator of nonsense transcripts homolog A (yeast) |
| chr14_+_104394770 | 1.10 |
ENST00000409874.4 ENST00000339063.5 |
TDRD9 |
tudor domain containing 9 |
| chr15_+_78730622 | 1.07 |
ENST00000560440.1 |
IREB2 |
iron-responsive element binding protein 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.2 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.1 | 2.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 2.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 1.9 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway(GO:0035666) |
| 0.1 | 1.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.0 | 1.6 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.2 | 1.5 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 1.3 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.1 | 1.2 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.2 | 1.1 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 2.2 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 1.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 1.9 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.2 | 1.5 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.1 | 1.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.2 | 1.1 | GO:0071547 | piP-body(GO:0071547) |
| 0.1 | 1.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 1.1 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 1.0 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.0 | 2.1 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 1.9 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 1.6 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.2 | 1.4 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.4 | 1.1 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.1 | 1.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 1.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.3 | 0.9 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.9 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.7 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.0 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 1.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 1.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.1 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 0.7 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |