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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ZEB1
Z-value: 9.24
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31608054_31608156 | -0.99 | 1.4e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_95653427 | 30.91 |
ENST00000454170.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr8_+_95653373 | 29.30 |
ENST00000358397.5 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr8_+_95653302 | 29.16 |
ENST00000423620.2 ENST00000433389.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr14_-_61747949 | 28.39 |
ENST00000355702.2 |
TMEM30B |
transmembrane protein 30B |
| chr19_+_35739597 | 27.35 |
ENST00000361790.3 |
LSR |
lipolysis stimulated lipoprotein receptor |
| chr19_+_35739631 | 27.23 |
ENST00000602003.1 ENST00000360798.3 ENST00000354900.3 |
LSR |
lipolysis stimulated lipoprotein receptor |
| chr19_+_35739782 | 26.94 |
ENST00000347609.4 |
LSR |
lipolysis stimulated lipoprotein receptor |
| chr1_-_27286897 | 23.61 |
ENST00000320567.5 |
C1orf172 |
chromosome 1 open reading frame 172 |
| chr6_-_136871957 | 23.43 |
ENST00000354570.3 |
MAP7 |
microtubule-associated protein 7 |
| chr19_-_10697895 | 22.80 |
ENST00000591240.1 ENST00000589684.1 ENST00000591676.1 ENST00000250244.6 ENST00000590923.1 |
AP1M2 |
adaptor-related protein complex 1, mu 2 subunit |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.8 | 123.8 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 1.2 | 102.5 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.6 | 89.1 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 12.2 | 60.9 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 1.9 | 55.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 6.1 | 55.0 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 17.8 | 53.5 | GO:0032773 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 0.4 | 44.7 | GO:0070268 | cornification(GO:0070268) |
| 1.5 | 39.6 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 2.8 | 38.6 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 291.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 14.8 | 133.6 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 101.0 | GO:0016604 | nuclear body(GO:0016604) |
| 0.5 | 74.2 | GO:0070160 | occluding junction(GO:0070160) |
| 0.7 | 66.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.9 | 60.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.3 | 44.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 36.7 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 2.9 | 35.3 | GO:0016342 | catenin complex(GO:0016342) |
| 1.8 | 29.5 | GO:0035253 | ciliary rootlet(GO:0035253) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 95.3 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.5 | 71.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 58.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 6.1 | 55.0 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.7 | 41.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 3.1 | 40.2 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.6 | 38.8 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.6 | 38.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.5 | 34.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.3 | 34.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 85.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.7 | 60.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 2.0 | 45.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.9 | 35.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 1.0 | 34.4 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 29.1 | PID P73PATHWAY | p73 transcription factor network |
| 0.7 | 25.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 24.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.7 | 23.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.7 | 18.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 97.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 2.0 | 63.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 3.1 | 59.0 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.6 | 53.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.3 | 31.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.6 | 29.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.7 | 26.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.2 | 26.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 1.3 | 22.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 20.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |