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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ZNF143
Z-value: 2.12
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Transcription factors associated with ZNF143
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF143 | hg19_v2_chr11_+_9482512_9482534 | -0.55 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF143
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_202316392 | 1.27 |
ENST00000194530.3 ENST00000392249.2 |
STRADB |
STE20-related kinase adaptor beta |
| chr2_-_202316260 | 1.14 |
ENST00000332624.3 |
TRAK2 |
trafficking protein, kinesin binding 2 |
| chr15_+_41913690 | 1.13 |
ENST00000563576.1 |
MGA |
MGA, MAX dimerization protein |
| chr19_-_44123734 | 1.07 |
ENST00000598676.1 |
ZNF428 |
zinc finger protein 428 |
| chr19_+_14551066 | 0.98 |
ENST00000342216.4 |
PKN1 |
protein kinase N1 |
| chr17_+_76210367 | 0.98 |
ENST00000592734.1 ENST00000587746.1 |
BIRC5 |
baculoviral IAP repeat containing 5 |
| chr12_+_107168418 | 0.97 |
ENST00000392839.2 ENST00000548914.1 ENST00000355478.2 ENST00000552619.1 ENST00000549643.1 |
RIC8B |
RIC8 guanine nucleotide exchange factor B |
| chr19_-_48673552 | 0.96 |
ENST00000536218.1 ENST00000596549.1 |
LIG1 |
ligase I, DNA, ATP-dependent |
| chr6_-_30709980 | 0.95 |
ENST00000416018.1 ENST00000445853.1 ENST00000413165.1 ENST00000418160.1 |
FLOT1 |
flotillin 1 |
| chr19_+_14544099 | 0.95 |
ENST00000242783.6 ENST00000586557.1 ENST00000590097.1 |
PKN1 |
protein kinase N1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.0 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.3 | 1.9 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.4 | 1.8 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.2 | 1.7 | GO:0035624 | receptor transactivation(GO:0035624) |
| 0.1 | 1.7 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.1 | 1.6 | GO:2000582 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.2 | 1.3 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.1 | 1.3 | GO:0048793 | pronephros development(GO:0048793) |
| 0.0 | 1.3 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 1.3 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 2.8 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 2.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 2.0 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 1.9 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.7 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 1.5 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 1.3 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 2.1 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 2.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.3 | 1.9 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.2 | 1.8 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 1.5 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 1.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.2 | 1.3 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 1.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 1.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 3.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.2 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.2 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.1 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 3.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.2 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.0 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.3 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.0 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.7 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.7 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 0.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |