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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ZNF691

Z-value: 0.70

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Transcription factors associated with ZNF691

Gene Symbol Gene ID Gene Info
ENSG00000164011.13 ZNF691

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF691hg19_v2_chr1_+_43312258_43312310-0.167.0e-01Click!

Activity profile of ZNF691 motif

Sorted Z-values of ZNF691 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF691

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_147232669 1.69 ENST00000369237.1
GJA5
gap junction protein, alpha 5, 40kDa
chr16_+_57662419 0.83 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr1_+_26856236 0.71 ENST00000374168.2
ENST00000374166.4
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr16_+_57662138 0.69 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
GPR56
G protein-coupled receptor 56
chr2_+_68961934 0.62 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961905 0.61 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr18_+_11751493 0.55 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_-_74669009 0.55 ENST00000272430.5
RTKN
rhotekin
chr19_+_50084561 0.54 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr2_+_106468204 0.52 ENST00000425756.1
ENST00000393349.2
NCK2
NCK adaptor protein 2
chr11_-_5323226 0.47 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr19_-_51472222 0.43 ENST00000376851.3
KLK6
kallikrein-related peptidase 6
chr16_+_53738053 0.42 ENST00000394647.3
FTO
fat mass and obesity associated
chr19_-_51472031 0.40 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr8_+_32579341 0.39 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr14_-_92333873 0.39 ENST00000435962.2
TC2N
tandem C2 domains, nuclear
chr2_+_68962014 0.35 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr11_+_121461097 0.35 ENST00000527934.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr9_+_71944241 0.30 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr5_-_35230434 0.27 ENST00000504500.1
PRLR
prolactin receptor
chr11_-_36619771 0.26 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chrX_+_102965835 0.24 ENST00000319560.6
TMEM31
transmembrane protein 31
chrX_-_103268259 0.22 ENST00000217926.5
H2BFWT
H2B histone family, member W, testis-specific
chrX_+_102469997 0.20 ENST00000372695.5
ENST00000372691.3
BEX4
brain expressed, X-linked 4
chr15_-_83018198 0.20 ENST00000557886.1
RP13-996F3.4
golgin A6 family-like 19
chr3_+_46412345 0.20 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr16_+_84328429 0.19 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr17_+_30771279 0.19 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_203055129 0.19 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr16_+_84328252 0.19 ENST00000219454.5
WFDC1
WAP four-disulfide core domain 1
chr3_-_10452359 0.18 ENST00000452124.1
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr9_+_139847347 0.17 ENST00000371632.3
LCN12
lipocalin 12
chr17_-_41738931 0.16 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr4_-_83719983 0.16 ENST00000319540.4
SCD5
stearoyl-CoA desaturase 5
chr8_-_145159083 0.15 ENST00000398712.2
SHARPIN
SHANK-associated RH domain interactor
chr15_-_26108355 0.15 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr6_+_28493753 0.14 ENST00000469384.1
GPX5
glutathione peroxidase 5 (epididymal androgen-related protein)
chr15_+_84908573 0.14 ENST00000424966.1
ENST00000422563.2
GOLGA6L4
golgin A6 family-like 4
chr17_-_73840415 0.14 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr4_-_120243545 0.13 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr20_-_1317555 0.13 ENST00000537552.1
AL136531.1
HCG2043693; Uncharacterized protein
chr9_+_84603687 0.13 ENST00000344803.2
SPATA31D1
SPATA31 subfamily D, member 1
chr12_-_109221160 0.13 ENST00000326470.5
SSH1
slingshot protein phosphatase 1
chr11_+_102188272 0.13 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr9_+_139553306 0.13 ENST00000371699.1
EGFL7
EGF-like-domain, multiple 7
chr12_-_51717875 0.13 ENST00000604560.1
BIN2
bridging integrator 2
chr12_-_51717948 0.12 ENST00000267012.4
BIN2
bridging integrator 2
chr8_+_145294015 0.12 ENST00000544576.1
MROH1
maestro heat-like repeat family member 1
chr6_+_151186554 0.12 ENST00000367321.3
ENST00000367307.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr11_-_57148619 0.12 ENST00000287143.2
PRG3
proteoglycan 3
chr12_-_51718436 0.12 ENST00000544402.1
BIN2
bridging integrator 2
chr11_+_33902189 0.12 ENST00000330381.2
AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr3_-_46037299 0.11 ENST00000296137.2
FYCO1
FYVE and coiled-coil domain containing 1
chr3_-_167452262 0.11 ENST00000487947.2
PDCD10
programmed cell death 10
chr12_-_51717922 0.11 ENST00000452142.2
BIN2
bridging integrator 2
chr5_-_39074479 0.10 ENST00000514735.1
ENST00000296782.5
ENST00000357387.3
RICTOR
RPTOR independent companion of MTOR, complex 2
chr1_+_248201474 0.10 ENST00000366479.2
OR2L2
olfactory receptor, family 2, subfamily L, member 2
chr15_-_58571445 0.10 ENST00000558231.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr9_+_37485932 0.09 ENST00000377798.4
ENST00000442009.2
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr1_-_935361 0.09 ENST00000484667.2
HES4
hes family bHLH transcription factor 4
chr17_-_38821373 0.09 ENST00000394052.3
KRT222
keratin 222
chr11_+_5410607 0.09 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr9_+_138453595 0.09 ENST00000479141.1
ENST00000371766.2
ENST00000277508.5
ENST00000433563.1
PAEP
progestagen-associated endometrial protein
chr9_+_37486005 0.09 ENST00000377792.3
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr1_+_178482262 0.08 ENST00000367641.3
ENST00000367639.1
TEX35
testis expressed 35
chr3_-_167452298 0.08 ENST00000475915.2
ENST00000462725.2
ENST00000461494.1
PDCD10
programmed cell death 10
chr17_-_3417062 0.08 ENST00000570318.1
ENST00000541913.1
SPATA22
spermatogenesis associated 22
chr22_-_43539346 0.08 ENST00000327555.5
ENST00000290429.6
MCAT
malonyl CoA:ACP acyltransferase (mitochondrial)
chr9_+_135854091 0.08 ENST00000450530.1
ENST00000534944.1
GFI1B
growth factor independent 1B transcription repressor
chr15_-_86338100 0.07 ENST00000536947.1
KLHL25
kelch-like family member 25
chr10_+_104678102 0.07 ENST00000433628.2
CNNM2
cyclin M2
chr12_-_11062161 0.07 ENST00000390677.2
TAS2R13
taste receptor, type 2, member 13
chr12_-_23737534 0.07 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr10_+_104678032 0.07 ENST00000369878.4
ENST00000369875.3
CNNM2
cyclin M2
chr13_-_52027134 0.07 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr11_-_133826852 0.07 ENST00000533871.2
ENST00000321016.8
IGSF9B
immunoglobulin superfamily, member 9B
chr3_-_167452614 0.06 ENST00000392750.2
ENST00000464360.1
ENST00000492139.1
ENST00000471885.1
ENST00000470131.1
PDCD10
programmed cell death 10
chr2_+_202098203 0.06 ENST00000450491.1
ENST00000440732.1
ENST00000392258.3
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr4_+_48492269 0.06 ENST00000327939.4
ZAR1
zygote arrest 1
chr6_-_90529418 0.06 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr6_-_27279949 0.06 ENST00000444565.1
ENST00000377451.2
POM121L2
POM121 transmembrane nucleoporin-like 2
chr5_+_7396141 0.06 ENST00000338316.4
ADCY2
adenylate cyclase 2 (brain)
chr1_+_33938236 0.05 ENST00000361328.3
ENST00000373413.2
ZSCAN20
zinc finger and SCAN domain containing 20
chr19_+_40877583 0.05 ENST00000596470.1
PLD3
phospholipase D family, member 3
chr1_+_178482212 0.05 ENST00000319416.2
ENST00000258298.2
ENST00000367643.3
ENST00000367642.3
TEX35
testis expressed 35
chr17_+_80416050 0.05 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr6_+_31553978 0.05 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr10_-_61122220 0.05 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C
family with sequence similarity 13, member C
chr8_+_20831460 0.04 ENST00000522604.1
RP11-421P23.1
RP11-421P23.1
chr5_-_131892501 0.04 ENST00000450655.1
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr6_+_31553901 0.04 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr9_-_135754164 0.04 ENST00000298545.3
AK8
adenylate kinase 8
chr15_+_84904525 0.04 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr1_+_15986364 0.04 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr10_+_122357721 0.04 ENST00000369071.2
C10orf85
chromosome 10 open reading frame 85
chr7_-_143059780 0.03 ENST00000409578.1
ENST00000409346.1
FAM131B
family with sequence similarity 131, member B
chr6_+_28493666 0.03 ENST00000412168.2
GPX5
glutathione peroxidase 5 (epididymal androgen-related protein)
chr6_+_31021973 0.03 ENST00000570223.1
ENST00000566475.1
ENST00000426185.1
HCG22
HLA complex group 22
chr1_-_148202536 0.03 ENST00000544708.1
PPIAL4D
peptidylprolyl isomerase A (cyclophilin A)-like 4D
chr8_+_140943416 0.03 ENST00000507535.3
C8orf17
chromosome 8 open reading frame 17
chr5_-_175395283 0.03 ENST00000513482.1
ENST00000265097.4
THOC3
THO complex 3
chrX_+_107069063 0.03 ENST00000262843.6
MID2
midline 2
chr11_+_44748361 0.03 ENST00000533202.1
ENST00000533080.1
ENST00000520358.2
ENST00000520999.2
TSPAN18
tetraspanin 18
chr17_-_61777459 0.03 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr10_-_99258135 0.03 ENST00000327238.10
ENST00000327277.7
ENST00000355839.6
ENST00000437002.1
ENST00000422685.1
MMS19
MMS19 nucleotide excision repair homolog (S. cerevisiae)
chr17_+_37824700 0.03 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr17_+_43922241 0.03 ENST00000329196.5
SPPL2C
signal peptide peptidase like 2C
chr8_-_28347737 0.02 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
FBXO16
F-box protein 16
chr1_+_26644441 0.02 ENST00000374213.2
CD52
CD52 molecule
chr9_+_116267536 0.02 ENST00000374136.1
RGS3
regulator of G-protein signaling 3
chr17_+_20978854 0.02 ENST00000456235.1
AC087393.1
AC087393.1
chr1_-_16763911 0.02 ENST00000375577.1
ENST00000335496.1
SPATA21
spermatogenesis associated 21
chr4_-_7105056 0.02 ENST00000504402.1
ENST00000499242.2
ENST00000501888.2
RP11-367J11.3
RP11-367J11.3
chr1_-_155232221 0.01 ENST00000355379.3
SCAMP3
secretory carrier membrane protein 3
chr7_-_84569561 0.01 ENST00000439105.1
AC074183.4
AC074183.4
chr6_-_144329531 0.01 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr1_-_111174054 0.01 ENST00000369770.3
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr2_-_203736452 0.01 ENST00000419460.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr15_+_89402148 0.01 ENST00000560601.1
ACAN
aggrecan
chr19_-_15560730 0.00 ENST00000389282.4
ENST00000263381.7
WIZ
widely interspaced zinc finger motifs
chr16_+_78133293 0.00 ENST00000566780.1
WWOX
WW domain containing oxidoreductase
chr8_-_102181718 0.00 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chr8_-_121457332 0.00 ENST00000518918.1
MRPL13
mitochondrial ribosomal protein L13
chr6_+_31021225 0.00 ENST00000565192.1
ENST00000562344.1
HCG22
HLA complex group 22
chr22_+_23264766 0.00 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr14_-_74296806 0.00 ENST00000555539.1
RP5-1021I20.2
RP5-1021I20.2
chr17_+_80416482 0.00 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0010652 pulmonary valve formation(GO:0003193) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.1 0.4 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.1 0.3 GO:1902948 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.7 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.5 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.1 0.5 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.1 0.3 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 0.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.2 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.3 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.1 GO:1904719 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.1 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.8 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.2 GO:1903862 regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:1902490 regulation of sperm capacitation(GO:1902490)
0.0 0.2 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.2 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.0 0.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.1 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.0 0.5 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.0 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.1 0.4 GO:0035514 DNA demethylase activity(GO:0035514)
0.1 0.3 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling