Motif ID: EN1,2.p2

Z-value: 1.350


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.533.3e-02Click!
EN1chr2_-_119322228-0.523.9e-02Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_98021144 2.567 NM_001114094
NM_013314
BLNK

B-cell linker

chr4_+_74500748 2.466 ALB
albumin
chr11_+_22652894 2.424 NM_005256
GAS2
growth arrest-specific 2
chr11_+_59979857 1.516 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr4_+_74488947 1.438 ALB
albumin
chr17_-_36928604 1.415 NM_002275
KRT15
keratin 15
chr14_-_105182025 1.169


chr6_+_32515596 1.106 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_-_158008763 1.081 NM_004288
CYTIP
cytohesin 1 interacting protein
chr17_-_61655915 0.936 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_-_105845570 0.930 IGHA1
immunoglobulin heavy constant alpha 1
chr2_-_88208650 0.913 NM_001443
FABP1
fatty acid binding protein 1, liver
chr10_+_114123828 0.903 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_-_78050515 0.877 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr12_-_101115677 0.869 NM_002674
PMCH
pro-melanin-concentrating hormone
chr12_+_111829191 0.848 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_31441390 0.836 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr17_-_37181636 0.821 JUP
junction plakoglobin
chr12_+_6424293 0.818 NM_001242
CD27
CD27 molecule
chr14_-_64479198 0.784 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_-_41811916 0.766 NM_001167827
TFEB
transcription factor EB
chr1_+_111217244 0.727 NM_000560
CD53
CD53 molecule
chr12_-_6356783 0.696 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr14_-_105182159 0.690 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr17_+_22996461 0.679 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_-_184756101 0.670 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_+_39874921 0.658 NM_004310
RHOH
ras homolog gene family, member H
chr2_+_33592445 0.650 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_-_176769141 0.633 NM_000505
F12
coagulation factor XII (Hageman factor)
chr2_+_68855436 0.620 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr6_+_30402203 0.608


chr14_+_87541220 0.603 NM_003608
GPR65
G protein-coupled receptor 65
chr22_+_38627031 0.602 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr2_-_113310796 0.583 NM_000576
IL1B
interleukin 1, beta
chr20_-_45410033 0.583 ZMYND8
zinc finger, MYND-type containing 8
chr3_-_150422474 0.578 NM_000096
CP
ceruloplasmin (ferroxidase)
chr7_+_20653490 0.551 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr6_+_32713160 0.548 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr8_-_28403652 0.530 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr10_+_114123765 0.527 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_121884091 0.523 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr11_+_7574992 0.510 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_71096830 0.499 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr15_-_53350383 0.486 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr19_+_45973139 0.481 NM_006533
MIA
melanoma inhibitory activity
chr6_+_14225836 0.480 NM_001040280
NM_004233
CD83

CD83 molecule

chr8_-_38577891 0.479


chr5_-_86739683 0.468 CCNH
cyclin H
chrX_+_128741578 0.466 SASH3
SAM and SH3 domain containing 3
chr12_+_111829121 0.463 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr20_+_61838479 0.461 LIME1
Lck interacting transmembrane adaptor 1
chr2_+_68445936 0.456 PLEK
pleckstrin
chr14_-_23107106 0.454 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr4_+_155703581 0.450 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr19_-_44518465 0.450 GMFG
glia maturation factor, gamma
chr6_+_6533932 0.449 NM_004271
LY86
lymphocyte antigen 86
chr4_+_74488835 0.446 NM_000477
ALB
albumin
chr3_-_152517204 0.441 NM_023915
GPR87
G protein-coupled receptor 87
chrX_+_128741562 0.439 NM_018990
SASH3
SAM and SH3 domain containing 3
chr22_+_38627129 0.433 GRAP2
GRB2-related adaptor protein 2
chr19_-_44518516 0.421 NM_004877
GMFG
glia maturation factor, gamma
chr6_-_123999640 0.419 NM_006073
TRDN
triadin
chr14_-_106149623 0.406


chr1_+_210275752 0.405 DTL
denticleless homolog (Drosophila)
chr1_+_154390939 0.402 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr20_+_61838389 0.399 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr12_-_121767272 0.395 NM_006018
GPR109B
G protein-coupled receptor 109B
chr19_+_47073029 0.384 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr11_+_22316242 0.384 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_-_24067347 0.383 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr8_+_11702803 0.381 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr12_+_6925997 0.378 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr14_+_94148466 0.376 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_-_229627412 0.374 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr3_+_99733432 0.374 NM_005290
GPR15
G protein-coupled receptor 15
chr7_-_25234582 0.373 NM_022150
NPVF
neuropeptide VF precursor
chr22_+_21053972 0.369


chr16_+_49288550 0.364 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr12_-_101396459 0.362 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_+_6926014 0.361 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr7_+_50318801 0.356 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr18_-_28247186 0.354


chr19_+_39402167 0.351 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_-_152185764 0.350 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr10_-_7722747 0.349 ITIH5
inter-alpha (globulin) inhibitor H5
chr14_-_106038573 0.347 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr16_+_28850760 0.342 NM_001178098
NM_001770
CD19

CD19 molecule

chr2_+_102401580 0.342 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_31823097 0.341 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr17_-_36347197 0.341 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr11_+_22646229 0.339 NM_177553
GAS2
growth arrest-specific 2
chr1_-_108032645 0.333 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr6_-_79732391 0.332 PHIP
pleckstrin homology domain interacting protein
chr19_-_56164628 0.331 NM_002774
KLK6
kallikrein-related peptidase 6
chr17_-_53946899 0.331 MTMR4
myotubularin related protein 4
chr2_+_171316462 0.329 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr4_-_77147625 0.324 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr10_-_105835525 0.323 COL17A1
collagen, type XVII, alpha 1
chr6_+_106653429 0.321 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr4_+_74493266 0.320 ALB
albumin
chr15_-_50375143 0.317 NM_018728
MYO5C
myosin VC
chr14_-_93924873 0.316 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_23998515 0.313 NM_001127621
GALE
UDP-galactose-4-epimerase
chrX_-_48655978 0.308 PIM2
pim-2 oncogene
chr16_+_55950195 0.308 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr7_+_106897737 0.305 NM_005295
GPR22
G protein-coupled receptor 22
chr6_+_32021831 0.304 CFB
complement factor B
chr5_-_176769094 0.304 F12
coagulation factor XII (Hageman factor)
chr3_-_122862391 0.303 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_101036407 0.303 NM_024057
NUP37
nucleoporin 37kDa
chr4_-_17415918 0.302 DCAF16
DDB1 and CUL4 associated factor 16
chr12_+_84792203 0.299 NM_006183
NTS
neurotensin
chr1_-_159459999 0.294 NM_001643
APOA2
apolipoprotein A-II
chr17_-_24491521 0.293 MYO18A
myosin XVIIIA
chr15_+_41672543 0.292 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_+_20788027 0.288 NM_001785
CDA
cytidine deaminase
chr5_-_169749215 0.288 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr14_-_94669547 0.288 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr9_-_103185621 0.287 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_+_74499651 0.282 ALB
albumin
chr1_+_210275541 0.275 NM_016448
DTL
denticleless homolog (Drosophila)
chr3_-_122862447 0.275 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_-_133126278 0.275 NM_078488
VNN2
vanin 2
chr1_+_111571803 0.272 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr7_+_115650240 0.272 NM_152829
TES
testis derived transcript (3 LIM domains)
chr5_+_68703036 0.269 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr13_-_45654296 0.269 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_51585004 0.267 NM_002273
KRT8
keratin 8
chr7_+_94130752 0.266 PEG10
paternally expressed 10
chr13_-_45577144 0.266 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_-_121883647 0.261 HGD
homogentisate 1,2-dioxygenase
chr12_-_61615124 0.260 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr17_-_26665144 0.260 EVI2B
ecotropic viral integration site 2B
chr14_+_59782222 0.257 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_+_68028407 0.256 LYZ
lysozyme
chr3_+_42176662 0.255 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr9_-_122852356 0.253 NM_001735
C5
complement component 5
chr6_-_154692906 0.251 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_+_86662356 0.250 NM_006536
CLCA2
chloride channel accessory 2
chrX_-_47374647 0.250 NM_002621
CFP
complement factor properdin
chr14_-_105280425 0.248 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_2593351 0.248 LOC652276
hypothetical LOC652276
chr6_+_12825818 0.248 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr18_+_27425727 0.247 NM_000371
TTR
transthyretin
chr9_-_122728993 0.246 NM_005658
TRAF1
TNF receptor-associated factor 1
chr15_-_32416336 0.245 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr15_-_63199228 0.242 PDCD7
programmed cell death 7
chr12_-_51253875 0.241 NM_175053
KRT74
keratin 74
chr14_-_93924663 0.240 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_105610144 0.239 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr16_+_29734785 0.238 C16orf53
chromosome 16 open reading frame 53
chr10_-_104168890 0.237 NM_002779
PSD
pleckstrin and Sec7 domain containing
chrX_-_7855400 0.237 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr4_+_74493174 0.236 ALB
albumin
chr13_+_52114565 0.234 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr1_+_57093030 0.234 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_+_74493218 0.234 ALB
albumin
chr1_-_27604656 0.230 WASF2
WAS protein family, member 2
chr19_+_61151009 0.230 NM_176811
NLRP8
NLR family, pyrin domain containing 8
chr18_-_29882555 0.230 NM_001198549
NOL4
nucleolar protein 4
chr1_+_240078655 0.229 NM_003686
NM_006027
EXO1

exonuclease 1

chr20_-_23915431 0.229 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr2_+_88966170 0.229


chr1_+_173111306 0.228 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr10_+_104169560 0.228 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr2_-_89073496 0.226 IGKC
immunoglobulin kappa constant
chr13_-_45654327 0.226 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_70539922 0.225 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr12_+_21059896 0.224 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr2_-_74235860 0.223


chr1_-_202726068 0.220 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr5_+_180399830 0.219 NM_152547
BTNL9
butyrophilin-like 9
chr4_+_74488910 0.219 ALB
albumin
chr9_+_33016482 0.219 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr3_+_195336625 0.218 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr5_+_67558217 0.218 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_24342158 0.216 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr10_+_17891348 0.215 NM_001009567
NM_002438
MRC1L1
MRC1
mannose receptor, C type 1-like 1
mannose receptor, C type 1
chr14_+_94117483 0.214 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_+_74496575 0.213 ALB
albumin
chr17_+_31562577 0.212 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr18_-_56190980 0.211 NM_005912
MC4R
melanocortin 4 receptor
chr12_-_89922888 0.211 NM_004950
EPYC
epiphycan
chr8_+_22900863 0.208 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr12_+_51783554 0.206 SOAT2
sterol O-acyltransferase 2
chr10_-_116408046 0.203 NM_002313
ABLIM1
actin binding LIM protein 1
chr3_+_48239865 0.202 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr8_+_28230567 0.202 NM_006228
PNOC
prepronociceptin
chr6_-_119512035 0.202 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr14_-_94677807 0.200 NM_030621
DICER1
dicer 1, ribonuclease type III
chr12_-_642786 0.200 NM_016533
NINJ2
ninjurin 2
chr12_+_119617060 0.200


chr5_-_150583808 0.197 CCDC69
coiled-coil domain containing 69
chr18_-_58005268 0.196 NM_012327
NM_176787
PIGN

phosphatidylinositol glycan anchor biosynthesis, class N

chr12_-_66933492 0.196 NM_020525
IL22
interleukin 22
chr3_-_137395966 0.195 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr10_-_52315436 0.195 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr17_+_43165608 0.195 NM_013351
TBX21
T-box 21
chr1_-_28392966 0.193 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr10_-_105835609 0.190 NM_000494
COL17A1
collagen, type XVII, alpha 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.18 2.58e-10 GO:0006955 immune response
1.79 4.15e-08 GO:0002376 immune system process
1.89 1.15e-05 GO:0006952 defense response
2.30 1.82e-03 GO:0006954 inflammatory response
1.21 2.04e-03 GO:0050896 response to stimulus
3.17 1.28e-02 GO:0007586 digestion
1.98 2.15e-02 GO:0051707 response to other organism
1.98 3.01e-02 GO:0045087 innate immune response
1.85 3.99e-02 GO:0009607 response to biotic stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 4.28e-09 GO:0005576 extracellular region
1.84 7.30e-06 GO:0005615 extracellular space
1.72 1.24e-05 GO:0044421 extracellular region part
1.26 2.31e-03 GO:0071944 cell periphery
1.26 3.00e-03 GO:0005886 plasma membrane
1.32 2.18e-02 GO:0044459 plasma membrane part
1.42 4.24e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.23 3.88e-08 GO:0005125 cytokine activity
5.28 8.01e-06 GO:0008009 chemokine activity
4.74 4.64e-05 GO:0042379 chemokine receptor binding
1.69 6.03e-05 GO:0005102 receptor binding
2.69 1.25e-04 GO:0005126 cytokine receptor binding
3.08 8.13e-03 GO:0005179 hormone activity
1.60 8.17e-03 GO:0004888 transmembrane receptor activity
1.45 3.10e-02 GO:0004872 receptor activity