Motif ID: ESR1.p2

Z-value: 1.647


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_152168500-0.175.2e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_129445002 1.497 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_129445017 1.492 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_129444997 1.293 APLP2
amyloid beta (A4) precursor-like protein 2
chr22_-_18309447 1.271 TXNRD2
thioredoxin reductase 2
chr11_+_129444877 1.226 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr4_-_57671307 1.203 IGFBP7
insulin-like growth factor binding protein 7
chr6_+_31976754 1.132 NM_001178063
C2
complement component 2
chr6_+_148705646 1.109 SASH1
SAM and SH3 domain containing 1
chr6_+_148705421 1.082 NM_015278
SASH1
SAM and SH3 domain containing 1
chr15_-_50375143 1.065 NM_018728
MYO5C
myosin VC
chr22_-_18309333 1.027 NM_006440
TXNRD2
thioredoxin reductase 2
chr10_+_115428924 1.019 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr7_+_45894480 0.990 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr22_-_18309250 0.978 TXNRD2
thioredoxin reductase 2
chr6_+_7486836 0.960 DSP
desmoplakin
chr16_+_54072969 0.937 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr18_+_53862744 0.936 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_7486891 0.924 DSP
desmoplakin
chr11_-_116213511 0.924 NM_000039
APOA1
apolipoprotein A-I
chr6_+_7486862 0.920 NM_001008844
NM_004415
DSP

desmoplakin

chr17_-_72218535 0.901 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr1_-_94475504 0.897 ARHGAP29
Rho GTPase activating protein 29
chr17_+_77261477 0.864 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr18_+_53862888 0.864 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_53862386 0.845 NM_001144967
NM_015277
NEDD4L

neural precursor cell expressed, developmentally down-regulated 4-like

chr1_-_94475840 0.826 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr6_-_47385313 0.825 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr16_+_64958025 0.823 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr9_-_73573121 0.793 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr21_+_41461924 0.790 BACE2
beta-site APP-cleaving enzyme 2
chr13_+_109757593 0.763 NM_001846
COL4A2
collagen, type IV, alpha 2
chr19_-_18578631 0.760 NM_004750
CRLF1
cytokine receptor-like factor 1
chr7_-_47588160 0.751 TNS3
tensin 3
chr7_-_47588266 0.728 TNS3
tensin 3
chr17_+_77261440 0.724 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr4_+_184257337 0.720 NM_024949
WWC2
WW and C2 domain containing 2
chr17_+_77261447 0.719 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_+_17501589 0.707 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr19_-_18578577 0.704 CRLF1
cytokine receptor-like factor 1
chr19_-_18578467 0.698 CRLF1
cytokine receptor-like factor 1
chr13_-_102249263 0.689 NM_024089
KDELC1
KDEL (Lys-Asp-Glu-Leu) containing 1
chrX_+_117745551 0.687 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr19_-_11234117 0.674 NM_020812
DOCK6
dedicator of cytokinesis 6
chr6_-_47385205 0.673 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_167342149 0.662 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_1727247 0.658 PXDN
peroxidasin homolog (Drosophila)
chr12_-_123023312 0.658 CCDC92
coiled-coil domain containing 92
chr2_-_1727324 0.656 PXDN
peroxidasin homolog (Drosophila)
chr17_+_77261401 0.654 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_-_82289006 0.654 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr2_+_236067424 0.645 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr19_+_54707739 0.638 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_2118916 0.637 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr22_-_36245155 0.636 NM_014550
CARD10
caspase recruitment domain family, member 10
chr2_+_187162969 0.636 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr17_+_71893014 0.621 SPHK1
sphingosine kinase 1
chr11_+_129445057 0.620 APLP2
amyloid beta (A4) precursor-like protein 2
chr21_+_41461962 0.616 BACE2
beta-site APP-cleaving enzyme 2
chr16_+_55217085 0.611 NM_175617
MT1E
metallothionein 1E
chr6_+_148705817 0.609 SASH1
SAM and SH3 domain containing 1
chr17_+_71892538 0.608 SPHK1
sphingosine kinase 1
chr17_+_71892271 0.605 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr9_+_136673464 0.601 NM_000093
COL5A1
collagen, type V, alpha 1
chr13_-_109757442 0.599 NM_001845
COL4A1
collagen, type IV, alpha 1
chr7_-_50828159 0.595 GRB10
growth factor receptor-bound protein 10
chr10_+_129595289 0.591 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr2_-_101134146 0.582 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr9_-_83493415 0.579 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr16_+_81218074 0.578 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr12_-_123023052 0.570 NM_025140
CCDC92
coiled-coil domain containing 92
chr4_-_122837501 0.562 ANXA5
annexin A5
chr3_+_52504391 0.561 NM_015136
STAB1
stabilin 1
chr21_+_45649719 0.560


chr10_-_126839546 0.558 NM_001083914
CTBP2
C-terminal binding protein 2
chr4_-_122837590 0.557 NM_001154
ANXA5
annexin A5
chr17_-_3518654 0.556 NM_014604
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr17_+_71892781 0.556 NM_001142602
SPHK1
sphingosine kinase 1
chr7_-_27190882 0.550 HOXA11
homeobox A11
chr11_+_822965 0.540 CD151
CD151 molecule (Raph blood group)
chr4_-_40911212 0.538 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr11_+_67836575 0.536 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr5_+_150380325 0.533 GPX3
glutathione peroxidase 3 (plasma)
chr4_+_4912272 0.532 NM_002448
MSX1
msh homeobox 1
chr3_+_52464657 0.532 NISCH
nischarin
chr4_-_122837579 0.532 ANXA5
annexin A5
chr5_+_150380270 0.529 GPX3
glutathione peroxidase 3 (plasma)
chr12_+_50631704 0.528 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr17_+_72648580 0.518 NM_001039573
NM_001143998
NM_001143999
NM_003003
SEC14L1



SEC14-like 1 (S. cerevisiae)



chr19_+_40242634 0.517 HPN
hepsin
chr22_+_42651007 0.501 PNPLA3
patatin-like phospholipase domain containing 3
chr5_+_150380173 0.501 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr22_+_42650951 0.501 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr16_+_8675904 0.496 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr11_-_63138516 0.494 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr22_+_42651018 0.492 PNPLA3
patatin-like phospholipase domain containing 3
chr11_-_63138061 0.491 PLA2G16
phospholipase A2, group XVI
chr11_-_63138483 0.486 NM_007069
PLA2G16
phospholipase A2, group XVI
chr11_-_63138416 0.485 PLA2G16
phospholipase A2, group XVI
chr17_-_72218661 0.485 MXRA7
matrix-remodelling associated 7
chr2_-_1727292 0.483 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr19_+_54708247 0.482 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_120810899 0.478 NM_001171993
HPD
4-hydroxyphenylpyruvate dioxygenase
chr19_+_40224457 0.476 HPN
hepsin
chr7_+_93976927 0.476 NM_022900
CASD1
CAS1 domain containing 1
chr21_+_17807167 0.472 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr19_+_47521600 0.471 NM_001410
MEGF8
multiple EGF-like-domains 8
chr17_-_3518568 0.466 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr5_-_141041933 0.465 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr9_+_123003549 0.463 GSN
gelsolin
chr19_+_54708302 0.461 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_+_72648696 0.460 SEC14L1
SEC14-like 1 (S. cerevisiae)
chr5_-_141041982 0.454 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr7_-_29995809 0.453 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr1_-_27113018 0.450 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr5_+_176446425 0.448 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr6_+_7672009 0.447 NM_001718
BMP6
bone morphogenetic protein 6
chr17_-_3518628 0.444 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr20_-_61039672 0.441 DIDO1
death inducer-obliterator 1
chr2_+_219354692 0.441 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_+_218992053 0.433 NM_007127
VIL1
villin 1
chr7_-_50828608 0.428 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr19_+_40224480 0.421 HPN
hepsin
chr6_-_47385470 0.416 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_181259317 0.412


chr9_-_14303509 0.412 NFIB
nuclear factor I/B
chr2_-_242096673 0.410 NM_006374
STK25
serine/threonine kinase 25
chr20_-_23566325 0.409 NM_000099
CST3
cystatin C
chr17_+_19377732 0.403 NM_018242
SLC47A1
solute carrier family 47, member 1
chr7_+_73506047 0.403 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr19_+_54708312 0.402 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_-_224612177 0.398 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr9_-_13269562 0.398 MPDZ
multiple PDZ domain protein
chr6_+_107917965 0.398 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr2_-_20714303 0.397 NM_022460
HS1BP3
HCLS1 binding protein 3
chr14_+_73073570 0.397 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr7_+_93977267 0.395 CASD1
CAS1 domain containing 1
chr17_-_75808680 0.393 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr1_+_149779384 0.392 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr22_-_18309312 0.384 TXNRD2
thioredoxin reductase 2
chr18_+_53967544 0.383 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr2_+_85213884 0.381 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr5_+_79739548 0.378 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr9_+_96528764 0.374 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr13_+_112670757 0.374 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_+_36632242 0.374 NM_033386
MICALL1
MICAL-like 1
chr9_+_96528814 0.370 C9orf3
chromosome 9 open reading frame 3
chr2_-_242096592 0.364 STK25
serine/threonine kinase 25
chr2_-_21079145 0.360 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_105012106 0.356 NM_001312
CRIP2
cysteine-rich protein 2
chr9_-_139202831 0.354 ANAPC2
anaphase promoting complex subunit 2
chr11_-_72031083 0.351 NM_001143839
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr4_-_89299034 0.350 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr2_-_242096122 0.350 STK25
serine/threonine kinase 25
chr6_-_47385605 0.344 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr9_-_139202855 0.342 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr19_-_4351357 0.342 SH3GL1
SH3-domain GRB2-like 1
chr12_-_69317441 0.341 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_-_105165805 0.339 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr19_+_15079141 0.337 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr13_+_112681626 0.337 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_-_33374678 0.335 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr7_+_73506172 0.334 GTF2IRD1
GTF2I repeat domain containing 1
chr8_+_38973681 0.325 ADAM9
ADAM metallopeptidase domain 9
chr5_-_1165106 0.324 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr13_+_97593411 0.323 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr21_-_45118037 0.321 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr19_+_54707637 0.320 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_+_52504410 0.320 STAB1
stabilin 1
chr3_-_173010921 0.319 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr16_-_55876099 0.319 PLLP
plasmolipin
chr2_-_219802482 0.315 ATG9A
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr18_+_18003401 0.314 NM_005257
GATA6
GATA binding protein 6
chr16_-_55876075 0.313 NM_015993
PLLP
plasmolipin
chr22_+_36927884 0.312 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr13_+_112789669 0.312 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_+_50697355 0.312 HLF
hepatic leukemia factor
chr8_+_38973588 0.311 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr13_-_27967215 0.311 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr19_+_50041424 0.311 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr2_+_36436873 0.310 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr12_-_78608154 0.310 PAWR
PRKC, apoptosis, WT1, regulator
chr7_-_35044177 0.309 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr16_+_3055313 0.308 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr16_+_55217180 0.307 MT1E
metallothionein 1E
chr2_+_182464713 0.307 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr8_+_123863224 0.306 ZHX2
zinc fingers and homeoboxes 2
chr10_-_52315390 0.306 A1CF
APOBEC1 complementation factor
chr6_-_2916280 0.304 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr17_-_34635446 0.301 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr8_+_61753793 0.299 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr9_-_110736143 0.297 IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr9_-_139202804 0.296 ANAPC2
anaphase promoting complex subunit 2
chr19_+_50041400 0.296 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_+_823007 0.294 CD151
CD151 molecule (Raph blood group)
chr6_-_52549673 0.294 TRAM2
translocation associated membrane protein 2
chr7_+_142789476 0.293 ZYX
zyxin
chr9_-_110736377 0.293 NM_003640
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr8_-_11762918 0.289 CTSB
cathepsin B
chr19_-_18913011 0.288 HOMER3
homer homolog 3 (Drosophila)
chr6_-_52549774 0.282 NM_012288
TRAM2
translocation associated membrane protein 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.70 1.90e-02 GO:0019199 transmembrane receptor protein kinase activity
1.12 4.64e-02 GO:0005515 protein binding