Motif ID: FOXP3.p2

Z-value: 1.154


Transcription factors associated with FOXP3.p2:

Gene SymbolEntrez IDGene Name
FOXP3 50943 forkhead box P3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXP3chrX_-_490081150.077.9e-01Click!


Activity profile for motif FOXP3.p2.

activity profile for motif FOXP3.p2


Sorted Z-values histogram for motif FOXP3.p2

Sorted Z-values for motif FOXP3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXP3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_26665220 2.275 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665213 2.264 EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 2.159 EVI2B
ecotropic viral integration site 2B
chr17_-_26665194 2.138 EVI2B
ecotropic viral integration site 2B
chr6_-_32605898 2.073 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chrX_-_100527799 1.900 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr4_+_39874921 1.835 NM_004310
RHOH
ras homolog gene family, member H
chr6_-_32665409 1.735 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr2_-_158008763 1.625 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_-_154719560 1.343 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr4_+_74493918 1.301 ALB
albumin
chr2_-_21079145 1.167 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_15862887 1.164


chr17_+_64922420 1.013 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr1_+_205694237 0.962 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr22_+_19458378 0.951 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_+_64414389 0.884 NM_015153
PHF3
PHD finger protein 3
chr10_+_114125003 0.876 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_205161821 0.870 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr15_-_78050515 0.798 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr9_-_115880425 0.759 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_+_116205830 0.703 NM_000040
APOC3
apolipoprotein C-III
chr16_+_70646008 0.698 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_190811479 0.682 NM_002922
RGS1
regulator of G-protein signaling 1
chrX_-_76824726 0.679 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr11_+_124329222 0.657 NM_025004
CCDC15
coiled-coil domain containing 15
chr9_-_36365965 0.655 RNF38
ring finger protein 38
chr15_-_91078307 0.630 FAM174B
family with sequence similarity 174, member B
chr1_-_149004852 0.602 CTSS
cathepsin S
chr9_-_115880366 0.574 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_89115825 0.553 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr11_+_124329286 0.526 CCDC15
coiled-coil domain containing 15
chr9_-_115880372 0.517 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_70180805 0.500 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr12_+_6424293 0.493 NM_001242
CD27
CD27 molecule
chr5_+_157090900 0.483 NM_017872
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr1_+_173111306 0.452 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_99391870 0.452 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_+_89115862 0.446 SPP1
secreted phosphoprotein 1
chr17_+_38306339 0.443 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr8_+_107807415 0.436 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_149004916 0.425 NM_004079
CTSS
cathepsin S
chr3_+_142175329 0.414 SLC25A36
solute carrier family 25, member 36
chr16_+_70654625 0.407 NM_020995
HPR
haptoglobin-related protein
chr9_-_115880281 0.407 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_154390939 0.401 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_123596921 0.400 NM_000586
IL2
interleukin 2
chr16_+_14976333 0.397 NM_015027
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr6_+_106653429 0.385 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr12_+_99391681 0.385 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr14_-_20969706 0.380 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr4_+_89115923 0.377 SPP1
secreted phosphoprotein 1
chr6_+_88026338 0.366 ZNF292
zinc finger protein 292
chr17_-_59825221 0.359


chr17_+_72692889 0.359 NM_001144001
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr7_+_21434818 0.357


chr19_-_6671585 0.351 NM_000064
C3
complement component 3
chr9_-_115880494 0.345 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_33151703 0.339 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr2_-_215605054 0.338 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr2_-_110319866 0.335 NM_000272
NM_001128178
NM_001128179
NM_207181
NPHP1



nephronophthisis 1 (juvenile)



chr10_+_97505398 0.318 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_196874759 0.301 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_-_89400935 0.300 IGKC
immunoglobulin kappa constant
chr19_+_47073029 0.283 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr17_+_24394043 0.279 NM_016518
PIPOX
pipecolic acid oxidase
chr1_-_172153087 0.278 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr5_-_32424352 0.266 ZFR
zinc finger RNA binding protein
chr12_+_49604782 0.266 NM_014033
METTL7A
methyltransferase like 7A
chr14_-_34414603 0.263 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr2_-_110319828 0.258 NPHP1
nephronophthisis 1 (juvenile)
chr21_-_33107813 0.253 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chrX_-_105169370 0.249 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_-_158815850 0.245 CD84
CD84 molecule
chr13_-_98708549 0.242 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr16_+_2807228 0.241 PRSS21
protease, serine, 21 (testisin)
chr1_-_159459999 0.240 NM_001643
APOA2
apolipoprotein A-II
chr1_+_116727514 0.234 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_172153024 0.232 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_78087484 0.227 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_33592445 0.226 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr15_+_83467295 0.222 PDE8A
phosphodiesterase 8A
chr4_-_103464491 0.215 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr6_-_11490487 0.215 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_76259976 0.210 NM_015687
FILIP1
filamin A interacting protein 1
chr1_-_159099090 0.206 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr19_-_60458915 0.203 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr8_-_17797127 0.202 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr12_+_15366712 0.196 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr16_+_2807164 0.195 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr22_-_43987010 0.193 NM_015264
KIAA0930
KIAA0930
chr12_+_51783540 0.192 NM_003578
SOAT2
sterol O-acyltransferase 2
chr2_+_143351536 0.190 NM_001032998
NM_003937
KYNU

kynureninase

chr1_+_66570363 0.168 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_-_70115037 0.165 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr6_+_144654565 0.162 NM_007124
UTRN
utrophin
chr6_+_37895244 0.158 NM_021943
ZFAND3
zinc finger, AN1-type domain 3
chr4_+_100714995 0.155 MTTP
microsomal triglyceride transfer protein
chr2_+_170149092 0.155 NM_004792
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr3_+_63859114 0.155 NM_001177387
ATXN7
ataxin 7
chr2_+_165860528 0.155 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_114433551 0.153 ANK2
ankyrin 2, neuronal
chr4_+_71096830 0.150 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr11_-_112851051 0.148 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr1_-_158815895 0.148 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_-_78217360 0.147 NM_003902
FUBP1
far upstream element (FUSE) binding protein 1
chr14_-_105948734 0.144 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr15_+_56511466 0.144 NM_000236
LIPC
lipase, hepatic
chr5_-_94442941 0.140 MCTP1
multiple C2 domains, transmembrane 1
chr8_+_124263932 0.140 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_+_102401580 0.140 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_31648071 0.138 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr4_-_186934059 0.136 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_-_122747470 0.136 NM_199420
POLQ
polymerase (DNA directed), theta
chr6_-_109795925 0.135 CD164
CD164 molecule, sialomucin
chr19_+_47416271 0.133 NM_133444
ZNF526
zinc finger protein 526
chr5_+_67622242 0.132 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_35327318 0.132 NM_018530
GSDMB
gasdermin B
chr11_+_86710076 0.125 TMEM135
transmembrane protein 135
chr9_+_12683385 0.124 NM_000550
TYRP1
tyrosinase-related protein 1
chr8_+_92184022 0.124 NM_001129890
LRRC69
leucine rich repeat containing 69
chr13_+_48582389 0.123 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr5_-_94443300 0.119 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr22_-_43986896 0.118 KIAA0930
KIAA0930
chr19_+_39402167 0.114 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_+_51968191 0.113 OSBPL9
oxysterol binding protein-like 9
chr15_-_63199228 0.110 PDCD7
programmed cell death 7
chr4_-_140280031 0.109 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_+_31838751 0.108 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr6_-_112147946 0.107 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chr9_-_103237851 0.105 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr6_+_31623331 0.104 NM_001144961
NM_005007
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr21_+_42946719 0.104 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr1_-_78217278 0.098 FUBP1
far upstream element (FUSE) binding protein 1
chr16_+_14976422 0.098 PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr5_+_161210280 0.096 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_-_151990061 0.093 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr15_+_46285789 0.092 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr14_+_101346032 0.091 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr16_-_12805194 0.089 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr2_-_166638376 0.089 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr10_+_124904269 0.089 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr18_-_72857951 0.087 MBP
myelin basic protein
chr2_-_74235860 0.087


chr3_-_173723754 0.084 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr17_-_10362583 0.084 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr11_+_58668827 0.081 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr13_+_94883853 0.080 NM_001160100
NM_182848
CLDN10

claudin 10

chr8_-_146173531 0.080 ZNF252
zinc finger protein 252
chr8_+_17874128 0.079 PCM1
pericentriolar material 1
chr12_-_131725848 0.079 POLE
polymerase (DNA directed), epsilon
chr6_-_17814596 0.077 NM_005124
NUP153
nucleoporin 153kDa
chr10_-_44794146 0.076 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr4_-_70396167 0.075 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr15_+_62578671 0.074 NM_015042
ZNF609
zinc finger protein 609
chr12_+_54646814 0.074 NM_001798
NM_052827
CDK2

cyclin-dependent kinase 2

chr19_-_44060729 0.074 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr16_-_68657256 0.073 PDXDC2P
pyridoxal-dependent decarboxylase domain containing 2, pseudogene
chr8_-_37847095 0.072 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr19_-_40996040 0.071 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr15_-_80428760 0.070 NM_001164465
GOLGA6L10
golgin A6 family-like 10
chr19_+_56958452 0.069 NM_001462
FPR2
formyl peptide receptor 2
chr11_+_62231689 0.066 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr16_+_68890559 0.065 NM_001014449
NM_001014451
NM_007242
DDX19B


DEAD (Asp-Glu-Ala-As) box polypeptide 19B


chr19_-_40995606 0.064 PRODH2
proline dehydrogenase (oxidase) 2
chr1_+_67404756 0.064 NM_144701
IL23R
interleukin 23 receptor
chr11_-_47502115 0.062 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr1_-_45868775 0.062 GPBP1L1
GC-rich promoter binding protein 1-like 1
chr11_+_30209138 0.060 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr3_-_180467483 0.060 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr15_+_75074743 0.059 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr3_-_172227152 0.059 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr4_+_71261066 0.058 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr8_-_91065961 0.058 NBN
nibrin
chr5_+_43645018 0.057 NNT
nicotinamide nucleotide transhydrogenase
chr10_+_112334066 0.054 SMC3
structural maintenance of chromosomes 3
chr13_+_110637173 0.054 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_89364273 0.053 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr3_+_170974745 0.053 NM_001185119
MYNN
myoneurin
chr11_+_10433241 0.051 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr4_+_88790477 0.050 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr9_-_21067804 0.049 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr6_-_30748760 0.048 NM_001164239
NM_003587
DHX16

DEAH (Asp-Glu-Ala-His) box polypeptide 16

chr22_+_16423147 0.048 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chrX_-_135690770 0.048 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr15_+_75074793 0.047 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr6_-_131426080 0.046 NM_001135555
NM_001135554
NM_001431
EPB41L2


erythrocyte membrane protein band 4.1-like 2


chr17_+_7402788 0.045 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr10_+_69539255 0.045 NM_032578
MYPN
myopalladin
chr17_-_59327602 0.045 NM_001317
NM_022640
NM_022641
CSH1


CSH2
chorionic somatomammotropin hormone 1 (placental lactogen)


chorionic somatomammotropin hormone 2
chr3_+_153468518 0.045 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr11_-_66201794 0.044 NM_031492
RBM4B
RNA binding motif protein 4B
chr22_+_27998367 0.044 EWSR1
Ewing sarcoma breakpoint region 1
chr18_-_72858037 0.043 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr7_+_141124710 0.043 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr5_+_140546839 0.043 NM_019119
PCDHB9
protocadherin beta 9
chr16_+_2672476 0.042 NM_018992
KCTD5
potassium channel tetramerisation domain containing 5
chr3_+_150675169 0.042 TM4SF4
transmembrane 4 L six family member 4
chr3_-_121065112 0.042


chr5_+_180348450 0.042 NM_197975
BTNL3
butyrophilin-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.19 1.63e-04 GO:0002376 immune system process
2.60 1.67e-04 GO:0006955 immune response
6.20 2.01e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
6.01 2.88e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
3.62 8.93e-04 GO:0050778 positive regulation of immune response
3.05 9.26e-04 GO:0002684 positive regulation of immune system process
3.00 1.23e-03 GO:0050776 regulation of immune response
3.89 2.32e-03 GO:0002253 activation of immune response
4.64 5.79e-03 GO:0006869 lipid transport
4.25 7.01e-03 GO:0051251 positive regulation of lymphocyte activation
3.99 1.45e-02 GO:0002757 immune response-activating signal transduction
11.21 1.45e-02 GO:0071825 protein-lipid complex subunit organization
11.21 1.45e-02 GO:0071827 plasma lipoprotein particle organization
4.25 1.52e-02 GO:0010876 lipid localization
3.97 1.56e-02 GO:0002696 positive regulation of leukocyte activation
8.60 1.73e-02 GO:0030301 cholesterol transport
3.92 1.79e-02 GO:0002764 immune response-regulating signaling pathway
3.89 1.91e-02 GO:0050867 positive regulation of cell activation
8.38 2.07e-02 GO:0015918 sterol transport
13.74 2.75e-02 GO:0044269 glycerol ether catabolic process
13.74 2.75e-02 GO:0046461 neutral lipid catabolic process
13.74 2.75e-02 GO:0046464 acylglycerol catabolic process
5.19 2.76e-02 GO:0050851 antigen receptor-mediated signaling pathway
6.44 3.83e-02 GO:0055088 lipid homeostasis
7.60 4.03e-02 GO:0042632 cholesterol homeostasis
7.60 4.03e-02 GO:0055092 sterol homeostasis
6.23 4.93e-02 GO:0006641 triglyceride metabolic process
18.68 4.93e-02 GO:0034374 low-density lipoprotein particle remodeling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 8.04e-03 GO:0071944 cell periphery
1.45 1.35e-02 GO:0005886 plasma membrane
1.66 3.91e-02 GO:0005576 extracellular region

Nothing significant found in function category.