Motif ID: GTF2A1,2.p2

Z-value: 2.151


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2A2chr15_-_57736828-0.361.8e-01Click!
GTF2A1chr14_-_80757327-0.214.2e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_100557098 2.990 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr3_-_147361465 2.930 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr19_+_46416938 2.725 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr3_-_147361626 2.705 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr21_+_41461597 2.308 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr1_-_56817823 2.300 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_13240868 2.271 NM_001423
EMP1
epithelial membrane protein 1
chr1_-_56817717 2.258 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_51777715 2.240 IGFBP6
insulin-like growth factor binding protein 6
chr11_-_111287657 2.196 NM_001885
CRYAB
crystallin, alpha B
chrX_-_3274680 2.162 NM_015419
MXRA5
matrix-remodelling associated 5
chr21_-_27139563 2.154 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr3_+_62279707 2.101 C3orf14
chromosome 3 open reading frame 14
chr11_-_118799452 2.051 NM_006288
THY1
Thy-1 cell surface antigen
chr3_-_147361912 2.003 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr12_+_79634820 1.975 NM_005593
MYF5
myogenic factor 5
chr15_+_78858763 1.927 NM_018689
KIAA1199
KIAA1199
chr1_-_20682541 1.914


chr21_+_41461924 1.887 BACE2
beta-site APP-cleaving enzyme 2
chr1_-_56817568 1.834 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_51777684 1.828 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr21_+_41461962 1.775 BACE2
beta-site APP-cleaving enzyme 2
chr16_+_54072969 1.761 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_-_23233426 1.754 LOXL2
lysyl oxidase-like 2
chr17_-_45633873 1.751 COL1A1
collagen, type I, alpha 1
chr17_+_45488330 1.734 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr8_-_18585721 1.703 PSD3
pleckstrin and Sec7 domain containing 3
chr7_-_41709191 1.687 NM_002192
INHBA
inhibin, beta A
chr13_-_44048601 1.651 NM_183422
TSC22D1
TSC22 domain family, member 1
chr21_+_46367216 1.622 COL6A2
collagen, type VI, alpha 2
chr8_-_67687980 1.606 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

hypothetical LOC645895
chr1_+_85819004 1.600 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_+_45488356 1.571 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr12_-_74711474 1.567 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr13_-_79810972 1.561 SPRY2
sprouty homolog 2 (Drosophila)
chr21_-_27139143 1.556 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_-_56817802 1.539 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_+_31526801 1.463 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr3_-_78749633 1.431 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_+_61522219 1.393 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr17_+_1611983 1.390 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_150569574 1.384 TM4SF1
transmembrane 4 L six family member 1
chr17_-_45633986 1.369 NM_000088
COL1A1
collagen, type I, alpha 1
chr11_+_130745580 1.268 NM_001048209
NTM
neurotrimin
chr2_+_30223253 1.258 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr2_-_161058120 1.247 RBMS1
RNA binding motif, single stranded interacting protein 1
chr19_-_50601406 1.233 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chrX_-_106130098 1.220 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr22_+_34107087 1.214 HMOX1
heme oxygenase (decycling) 1
chr15_+_37660568 1.197 NM_003246
THBS1
thrombospondin 1
chr17_+_1612092 1.172 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_+_123083540 1.168 GSN
gelsolin
chr3_-_150858274 1.165 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr12_-_7136189 1.145 C1R
complement component 1, r subcomponent
chr11_-_118799058 1.138 THY1
Thy-1 cell surface antigen
chr22_+_34107051 1.135 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr2_+_30223304 1.115 YPEL5
yippee-like 5 (Drosophila)
chr3_+_101694098 1.107 NM_018004
TMEM45A
transmembrane protein 45A
chr21_+_34112456 1.101 ITSN1
intersectin 1 (SH3 domain protein)
chr12_-_7136147 1.082 NM_001733
C1R
complement component 1, r subcomponent
chr1_-_68470585 1.080 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr19_-_48723150 1.079 NM_014297
ETHE1
ethylmalonic encephalopathy 1
chr15_-_88150823 1.043 ANPEP
alanyl (membrane) aminopeptidase
chr17_+_1612056 1.040 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_54025414 1.030 GMFB
glia maturation factor, beta
chr11_+_13255836 0.983 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr3_-_48105287 0.982 MAP4
microtubule-associated protein 4
chrX_-_114158388 0.963 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr8_-_145119627 0.947 NM_201378
PLEC
plectin
chr1_+_163084707 0.944 PBX1
pre-B-cell leukemia homeobox 1
chr4_+_41309668 0.941 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr2_+_28469850 0.938 FOSL2
FOS-like antigen 2
chr15_+_30721161 0.936 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr14_+_74815233 0.922 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_+_13240987 0.922 EMP1
epithelial membrane protein 1
chr17_+_4795128 0.919 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr7_+_68701704 0.918 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr2_+_30223372 0.914 YPEL5
yippee-like 5 (Drosophila)
chr17_-_1335763 0.913 NM_001080950
MYO1C
myosin IC
chr2_-_210876560 0.911 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr6_-_46401363 0.909 NM_005822
RCAN2
regulator of calcineurin 2
chr15_+_65245546 0.897 NM_001145104
SMAD3
SMAD family member 3
chr9_+_138991775 0.895 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr3_+_101694244 0.892 TMEM45A
transmembrane protein 45A
chr8_-_42184194 0.873 PLAT
plasminogen activator, tissue
chr1_+_63831479 0.871 NM_002633
PGM1
phosphoglucomutase 1
chr11_+_13255948 0.862 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr15_-_75150177 0.859 TSPAN3
tetraspanin 3
chr11_+_13255952 0.858 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr8_-_134378630 0.853 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr1_+_203740391 0.847 CDK18
cyclin-dependent kinase 18
chr9_+_115303527 0.842 NM_130795
RGS3
regulator of G-protein signaling 3
chr19_+_46417099 0.842 AXL
AXL receptor tyrosine kinase
chr11_+_13255913 0.837 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr5_+_34723420 0.836 NM_001145523
RAI14
retinoic acid induced 14
chr1_+_161305558 0.834 NM_001113381
RGS4
regulator of G-protein signaling 4
chr13_-_39075200 0.832 LHFP
lipoma HMGIC fusion partner
chr9_+_138991835 0.828 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr7_-_526005 0.825 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chrX_-_128485134 0.825 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr19_+_46416971 0.824 AXL
AXL receptor tyrosine kinase
chr20_-_55718982 0.822 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr19_+_46416975 0.809 AXL
AXL receptor tyrosine kinase
chr1_-_31942206 0.805 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr1_+_78243181 0.801 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_-_150578103 0.795 TM4SF1
transmembrane 4 L six family member 1
chr8_+_70541412 0.793 NM_001128204
NM_015170
SULF1

sulfatase 1

chr13_-_44048391 0.793 TSC22D1
TSC22 domain family, member 1
chr7_+_94130673 0.790 PEG10
paternally expressed 10
chr13_-_37070862 0.780 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr10_-_91092410 0.780 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr22_+_29817315 0.778 SMTN
smoothelin
chr22_-_41372920 0.775 NM_001129819
NM_001171661
NM_007326
CYB5R3


cytochrome b5 reductase 3


chr2_+_28469199 0.774 FOSL2
FOS-like antigen 2
chr1_+_154351162 0.774 LMNA
lamin A/C
chr1_-_219982081 0.773 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr1_+_154351200 0.761 LMNA
lamin A/C
chr15_-_75150574 0.757 NM_001168412
NM_005724
NM_198902
TSPAN3


tetraspanin 3


chr16_+_22733307 0.752 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_-_6490214 0.752 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

chr1_+_161305188 0.749 NM_005613
RGS4
regulator of G-protein signaling 4
chr2_-_190635566 0.749 NM_005259
MSTN
myostatin
chr1_-_32940943 0.745 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr11_+_13255925 0.738 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_66827563 0.736 SSH3
slingshot homolog 3 (Drosophila)
chr12_-_45052286 0.732 SLC38A2
solute carrier family 38, member 2
chr2_+_73973640 0.731 ACTG2
actin, gamma 2, smooth muscle, enteric
chr6_+_151688327 0.729 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr3_-_48105637 0.723 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr1_+_21639146 0.722 NM_032264
NBPF3
neuroblastoma breakpoint family, member 3
chr21_+_46370220 0.721 COL6A2
collagen, type VI, alpha 2
chr7_-_150605112 0.719 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr12_-_6321417 0.711 NM_001065
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr1_+_203740306 0.710 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr1_-_16355013 0.708 NM_004431
EPHA2
EPH receptor A2
chr9_+_2612134 0.703 VLDLR
very low density lipoprotein receptor
chr22_+_29122932 0.702 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr14_-_54025464 0.701 NM_004124
GMFB
glia maturation factor, beta
chr11_+_13255967 0.699 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr10_+_53744043 0.692 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr2_+_73973600 0.685 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr19_-_56178882 0.685 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr2_-_218516950 0.683 NM_022648
TNS1
tensin 1
chr17_+_18566060 0.676 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr19_+_40931285 0.662 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr1_+_39569396 0.658 NM_033044
MACF1
microtubule-actin crosslinking factor 1
chr1_-_207891264 0.658 NM_001017402
LAMB3
laminin, beta 3
chr22_-_36998889 0.656 TMEM184B
transmembrane protein 184B
chr10_-_125841840 0.656 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr12_-_45052830 0.656 NM_018976
SLC38A2
solute carrier family 38, member 2
chr21_-_26175068 0.651 APP
amyloid beta (A4) precursor protein
chr12_-_74711642 0.648 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr22_-_36998615 0.647 NM_001195071
TMEM184B
transmembrane protein 184B
chr7_+_94130752 0.644 PEG10
paternally expressed 10
chr4_-_111777956 0.644 NM_153426
NM_153427
PITX2

paired-like homeodomain 2

chr17_+_64020120 0.636 NM_002734
NM_212472
PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr15_+_61127367 0.634 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr7_+_99537065 0.626 NM_004722
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr22_-_36998912 0.619 NM_001195072
NM_012264
TMEM184B

transmembrane protein 184B

chr19_+_40299058 0.616 FXYD3
FXYD domain containing ion transport regulator 3
chr13_+_109952014 0.612 COL4A2
collagen, type IV, alpha 2
chr22_+_28032950 0.609 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr2_-_9481035 0.608 ITGB1BP1
integrin beta 1 binding protein 1
chr9_-_5427825 0.607 NM_018465
C9orf46
chromosome 9 open reading frame 46
chr4_+_74500748 0.597 ALB
albumin
chr2_+_200879656 0.597 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr12_-_54392328 0.596 NM_001144997
ITGA7
integrin, alpha 7
chr10_+_121400741 0.594 NM_004281
BAG3
BCL2-associated athanogene 3
chr1_-_219982016 0.593 DUSP10
dual specificity phosphatase 10
chrX_-_106846924 0.592 NM_004089
TSC22D3
TSC22 domain family, member 3
chr9_+_115396020 0.588 NM_144489
RGS3
regulator of G-protein signaling 3
chr13_+_35904408 0.588 NM_001111045
NM_003914
CCNA1

cyclin A1

chr18_+_3402071 0.586 NM_174886
TGIF1
TGFB-induced factor homeobox 1
chr20_-_43889339 0.586 NM_003279
TNNC2
troponin C type 2 (fast)
chr15_-_73792234 0.584 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr1_-_31942142 0.578 COL16A1
collagen, type XVI, alpha 1
chrX_+_70438352 0.571 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr5_-_142057692 0.567 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr20_-_55718351 0.566 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr4_-_111763655 0.564 NM_000325
PITX2
paired-like homeodomain 2
chr20_+_43875078 0.562 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr17_-_77602493 0.561 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr20_-_43410437 0.556 NM_002999
SDC4
syndecan 4
chr5_-_111340421 0.556 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chrX_-_153290697 0.549 NM_006730
DNASE1L1
deoxyribonuclease I-like 1
chr11_+_13255905 0.546 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr1_+_181380837 0.545 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr2_-_9481038 0.544 NM_004763
NM_022334
ITGB1BP1

integrin beta 1 binding protein 1

chr11_+_32068990 0.541 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr19_-_50518072 0.534 NM_001824
CKM
creatine kinase, muscle
chr2_-_37727472 0.532 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr3_-_150578207 0.530 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr13_+_31503436 0.527 NM_023037
FRY
furry homolog (Drosophila)
chr11_+_113671744 0.524 NM_006169
NNMT
nicotinamide N-methyltransferase
chr19_-_62028185 0.521 NM_001146186
PEG3
paternally expressed 3
chr4_+_169789327 0.519 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr12_+_6923441 0.519 NM_138425
C12orf57
chromosome 12 open reading frame 57
chr17_+_64020155 0.518 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr7_-_136678815 0.517 PTN
pleiotrophin
chr13_-_109757442 0.514 NM_001845
COL4A1
collagen, type IV, alpha 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 2.30e-05 GO:0032501 multicellular organismal process
3.29 9.41e-04 GO:0002576 platelet degranulation
1.30 1.43e-03 GO:0048856 anatomical structure development
1.44 6.12e-03 GO:0009653 anatomical structure morphogenesis
1.25 9.16e-03 GO:0032502 developmental process
1.29 1.13e-02 GO:0048731 system development
3.83 1.78e-02 GO:0050818 regulation of coagulation
2.03 1.95e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
1.25 2.16e-02 GO:0007275 multicellular organismal development
2.42 3.28e-02 GO:0034330 cell junction organization
3.84 3.70e-02 GO:0030193 regulation of blood coagulation
1.98 4.54e-02 GO:0001568 blood vessel development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 1.13e-11 GO:0005576 extracellular region
1.68 1.34e-06 GO:0044421 extracellular region part
1.62 4.37e-04 GO:0005615 extracellular space
1.89 3.39e-03 GO:0031012 extracellular matrix
2.16 4.22e-03 GO:0030141 stored secretory granule
3.15 9.88e-03 GO:0031091 platelet alpha granule
3.24 1.23e-02 GO:0031983 vesicle lumen
1.96 2.70e-02 GO:0016323 basolateral plasma membrane
1.20 3.43e-02 GO:0005886 plasma membrane
1.20 3.62e-02 GO:0071944 cell periphery

Nothing significant found in function category.