Motif ID: KLF4.p3

Z-value: 4.063


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1092905280.674.7e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_54835162 8.511 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr10_-_126839546 5.946 NM_001083914
CTBP2
C-terminal binding protein 2
chr11_+_65443303 4.841 NM_006442
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr11_+_65443452 4.808 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr10_-_126839056 4.779 NM_001329
CTBP2
C-terminal binding protein 2
chr11_-_11987115 4.763 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_-_126839000 4.670 CTBP2
C-terminal binding protein 2
chrX_-_140098959 4.634 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140098941 4.628 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140099014 4.547 LDOC1
leucine zipper, down-regulated in cancer 1
chr22_+_41877502 4.362 TSPO
translocator protein (18kDa)
chr12_-_45759691 4.336 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr15_+_88732474 4.333 NM_003870
IQGAP1
IQ motif containing GTPase activating protein 1
chr2_-_235070431 4.156 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr13_-_109236897 4.049 NM_003749
IRS2
insulin receptor substrate 2
chr11_+_65443484 4.034 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr14_-_104515738 4.017 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr17_+_45488330 3.978 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chrX_+_48915127 3.962 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr19_+_43447262 3.951 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr7_+_115953582 3.948 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr7_+_115926855 3.888 CAV2
caveolin 2
chr3_+_137167153 3.791 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr15_+_88732493 3.592 IQGAP1
IQ motif containing GTPase activating protein 1
chr12_+_51777684 3.539 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr11_-_11987458 3.529 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr3_+_137167296 3.502 PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr8_+_94998258 3.495 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr11_-_11987198 3.463 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr12_+_51777715 3.445 IGFBP6
insulin-like growth factor binding protein 6
chr7_+_115952074 3.432 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr1_-_150276091 3.289 S100A11
S100 calcium binding protein A11
chr15_+_88732453 3.266 IQGAP1
IQ motif containing GTPase activating protein 1
chr20_+_56318245 3.248 RAB22A
RAB22A, member RAS oncogene family
chr19_+_43447078 3.226 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_+_88732513 3.117 IQGAP1
IQ motif containing GTPase activating protein 1
chr1_+_144287344 3.115 NM_006099
PIAS3
protein inhibitor of activated STAT, 3
chrX_+_64804235 3.096 NM_002444
MSN
moesin
chr17_+_45488356 3.069 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr3_-_45242624 3.060 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr2_-_37752731 3.045 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr22_+_41877470 3.035 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr18_+_19706979 3.032 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr17_-_829655 3.013 NM_022463
NXN
nucleoredoxin
chrX_+_64804318 2.984 MSN
moesin
chr2_-_1727292 2.974 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chrX_+_64804259 2.954 MSN
moesin
chr1_-_150232927 2.949 S100A10
S100 calcium binding protein A10
chr22_-_35113797 2.943 MYH9
myosin, heavy chain 9, non-muscle
chr1_+_28791593 2.915 NM_001193532
RAB42
RAB42, member RAS oncogene family
chr17_-_1566223 2.792 C17orf91
chromosome 17 open reading frame 91
chr12_-_13044314 2.783 HEBP1
heme binding protein 1
chr15_+_61356801 2.782 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr12_-_13044467 2.763 NM_015987
HEBP1
heme binding protein 1
chr19_-_12747263 2.753 HOOK2
hook homolog 2 (Drosophila)
chr20_+_56318415 2.726 RAB22A
RAB22A, member RAS oncogene family
chr4_+_79691875 2.690 ANXA3
annexin A3
chr13_+_72531098 2.689 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr22_-_35113947 2.673 MYH9
myosin, heavy chain 9, non-muscle
chr1_+_26479030 2.661 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr19_+_53520632 2.648 EMP3
epithelial membrane protein 3
chr4_-_57671273 2.645 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr4_-_57671307 2.615 IGFBP7
insulin-like growth factor binding protein 7
chr10_-_3204955 2.609 PITRM1
pitrilysin metallopeptidase 1
chr10_+_75427853 2.562 NM_003373
NM_014000
VCL

vinculin

chr9_-_109291575 2.559 KLF4
Kruppel-like factor 4 (gut)
chr19_+_43446937 2.475 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr3_-_125085834 2.473 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr19_+_40298571 2.454 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr10_-_3204907 2.450 PITRM1
pitrilysin metallopeptidase 1
chr4_-_57671112 2.447 IGFBP7
insulin-like growth factor binding protein 7
chr1_+_144287368 2.435 PIAS3
protein inhibitor of activated STAT, 3
chr22_-_35114001 2.382 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr11_+_12652427 2.372 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr8_+_15442123 2.363 TUSC3
tumor suppressor candidate 3
chr15_+_72005847 2.336 LOXL1
lysyl oxidase-like 1
chr10_+_17312654 2.335 VIM
vimentin
chr12_-_53099269 2.335 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr5_+_96023926 2.327 CAST
calpastatin
chr14_-_51605695 2.310 NM_007361
NID2
nidogen 2 (osteonidogen)
chr12_-_53099203 2.304 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr15_+_72005839 2.285 NM_005576
LOXL1
lysyl oxidase-like 1
chr1_-_109386112 2.264 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr7_+_115952279 2.244 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr2_+_241023703 2.222 NM_002081
GPC1
glypican 1
chr19_+_53520439 2.216 NM_001425
EMP3
epithelial membrane protein 3
chr7_-_87687276 2.212 SRI
sorcin
chr9_-_109291866 2.200 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr2_-_37752272 2.190 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr7_+_115952325 2.183 CAV1
caveolin 1, caveolae protein, 22kDa
chr8_+_26204997 2.180 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr22_+_29807231 2.139 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr12_-_53099277 2.116 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_525532 2.108 NM_001130442
NM_005343
NM_176795
HRAS


v-Ha-ras Harvey rat sarcoma viral oncogene homolog


chr11_-_11987414 2.099 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr1_-_150233337 2.098 NM_002966
S100A10
S100 calcium binding protein A10
chr8_-_145085616 2.063 NM_201384
PLEC
plectin
chr16_+_670115 2.050 NM_005861
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr10_+_17311788 2.049 VIM
vimentin
chr1_+_158441770 2.042 PEA15
phosphoprotein enriched in astrocytes 15
chr7_-_87687302 2.042 NM_003130
SRI
sorcin
chr14_+_95575319 2.034 C14orf132
chromosome 14 open reading frame 132
chr10_-_74925653 2.028 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chrX_-_37591703 2.023 DYNLT3
dynein, light chain, Tctex-type 3
chr12_-_48963505 2.020 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr4_-_71924409 2.016 GRSF1
G-rich RNA sequence binding factor 1
chr16_+_31390567 2.002 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr12_+_47498778 1.990 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr19_-_6718417 1.989 NM_005490
SH2D3A
SH2 domain containing 3A
chr11_-_63770716 1.985 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr8_-_145088679 1.979 NM_201383
PLEC
plectin
chr2_-_158440587 1.952 NM_001111067
ACVR1
activin A receptor, type I
chr1_-_150232900 1.951 S100A10
S100 calcium binding protein A10
chr8_-_145122884 1.945 NM_000445
PLEC
plectin
chr12_-_105056577 1.936 NUAK1
NUAK family, SNF1-like kinase, 1
chr10_+_17311962 1.935 VIM
vimentin
chr13_+_35904408 1.926 NM_001111045
NM_003914
CCNA1

cyclin A1

chr10_+_17311347 1.925 VIM
vimentin
chr17_-_72218661 1.918 MXRA7
matrix-remodelling associated 7
chr1_+_40278958 1.918 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr7_+_79602023 1.914 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr14_-_104705753 1.900 JAG2
jagged 2
chr10_+_121400741 1.887 NM_004281
BAG3
BCL2-associated athanogene 3
chr10_+_17311242 1.883 VIM
vimentin
chr11_+_822965 1.875 CD151
CD151 molecule (Raph blood group)
chr1_-_117011824 1.874 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chrX_-_152804731 1.872 L1CAM
L1 cell adhesion molecule
chr2_-_1727247 1.868 PXDN
peroxidasin homolog (Drosophila)
chr7_+_100302885 1.864 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr10_+_17311307 1.860 VIM
vimentin
chr10_+_17311283 1.856 VIM
vimentin
chr11_+_823007 1.853 CD151
CD151 molecule (Raph blood group)
chr10_+_17311282 1.852 VIM
vimentin
chr15_+_72006015 1.848 LOXL1
lysyl oxidase-like 1
chr22_-_35113923 1.846 MYH9
myosin, heavy chain 9, non-muscle
chr4_-_71924477 1.840 NM_002092
GRSF1
G-rich RNA sequence binding factor 1
chr9_-_35679799 1.839 TPM2
tropomyosin 2 (beta)
chr4_+_87734489 1.834 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr1_-_167603623 1.818 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr5_-_16989371 1.817 NM_012334
MYO10
myosin X
chr4_+_174326464 1.817 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr17_-_7248137 1.811 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 read-through transcript
chromosome 17 open reading frame 61
chr2_+_173000590 1.809 ITGA6
integrin, alpha 6
chrX_-_135161185 1.798 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr4_+_169989680 1.791 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr11_+_822909 1.785 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr22_+_36632242 1.775 NM_033386
MICALL1
MICAL-like 1
chr4_+_99401543 1.765 NM_001100426
NM_001100427
NM_001100428
NM_001100429
NM_001100430
NM_021159
RAP1GDS1





RAP1, GTP-GDP dissociation stimulator 1





chr4_-_7991992 1.762 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr10_+_17310475 1.756 VIM
vimentin
chr20_+_56318155 1.753 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr1_-_32940943 1.744 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr1_+_26479167 1.724 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr17_-_3518568 1.714 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr11_-_497151 1.708 RNH1
ribonuclease/angiogenin inhibitor 1
chr1_+_26479173 1.704 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr10_-_3204979 1.691 NM_014889
PITRM1
pitrilysin metallopeptidase 1
chr3_-_49424427 1.682 RHOA
ras homolog gene family, member A
chr5_+_96024434 1.673 CAST
calpastatin
chr1_-_85514580 1.659 BCL10
B-cell CLL/lymphoma 10
chr9_-_115877104 1.655 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_1727324 1.652 PXDN
peroxidasin homolog (Drosophila)
chr3_-_49424397 1.644 RHOA
ras homolog gene family, member A
chr13_+_35903966 1.643 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr20_+_17498507 1.639 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr12_-_46585032 1.638 NM_000376
NM_001017535
VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

chr10_+_13182061 1.624 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr9_+_90193058 1.620 NM_006717
SPIN1
spindlin 1
chr1_+_26479208 1.616 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr11_-_85457736 1.612 PICALM
phosphatidylinositol binding clathrin assembly protein
chrX_-_34585287 1.608 NM_031442
TMEM47
transmembrane protein 47
chr8_-_145119627 1.604 NM_201378
PLEC
plectin
chr2_-_55130925 1.602 RTN4
reticulon 4
chr18_-_50004770 1.591 MBD2
methyl-CpG binding domain protein 2
chr11_+_64838882 1.588 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr3_-_49424380 1.583 RHOA
ras homolog gene family, member A
chr18_+_59295123 1.580 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chrX_-_37591760 1.574 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr5_+_86599800 1.572 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr8_-_102031943 1.570 NM_001135702
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_-_129024665 1.566 NM_001003794
MGLL
monoglyceride lipase
chr3_-_49424404 1.565 RHOA
ras homolog gene family, member A
chr19_-_12747421 1.564 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr12_+_12935619 1.561 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr6_-_166960690 1.561 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_-_49424413 1.558 RHOA
ras homolog gene family, member A
chr5_+_96023627 1.553 NM_001042440
CAST
calpastatin
chr7_-_80386602 1.552 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr8_-_99906944 1.525 NM_006281
STK3
serine/threonine kinase 3
chr1_+_40278841 1.523 NM_001105530
NM_006367
CAP1

CAP, adenylate cyclase-associated protein 1 (yeast)

chr15_-_58477407 1.518 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr9_-_35679902 1.513 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr11_-_497242 1.510 NM_203386
NM_203387
NM_203388
NM_203389
RNH1



ribonuclease/angiogenin inhibitor 1



chr14_-_51605515 1.509 NID2
nidogen 2 (osteonidogen)
chr12_+_67290951 1.509 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr1_+_221966684 1.503 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr11_-_2907169 1.500 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr17_-_17667580 1.495 SREBF1
sterol regulatory element binding transcription factor 1
chr12_+_67290977 1.494 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr12_+_12935759 1.492 GPRC5A
G protein-coupled receptor, family C, group 5, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.05 1.44e-07 GO:0009987 cellular process
1.08 4.55e-06 GO:0050794 regulation of cellular process
1.07 1.25e-05 GO:0050789 regulation of biological process
1.06 4.97e-05 GO:0065007 biological regulation
1.19 5.59e-04 GO:0051641 cellular localization
1.24 1.12e-03 GO:0046907 intracellular transport
1.14 1.41e-03 GO:0048523 negative regulation of cellular process
1.12 3.57e-03 GO:0048519 negative regulation of biological process
1.19 5.13e-03 GO:0051649 establishment of localization in cell
1.19 1.13e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.06 1.14e-02 GO:0044237 cellular metabolic process
1.09 2.28e-02 GO:0023052 signaling
1.26 3.27e-02 GO:0034613 cellular protein localization
1.25 3.94e-02 GO:0070727 cellular macromolecule localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 1.09e-16 GO:0044424 intracellular part
1.09 1.14e-16 GO:0005737 cytoplasm
1.06 2.20e-15 GO:0005622 intracellular
1.07 4.40e-12 GO:0043229 intracellular organelle
1.07 5.26e-12 GO:0043226 organelle
1.09 5.67e-09 GO:0044444 cytoplasmic part
1.07 6.81e-09 GO:0043231 intracellular membrane-bounded organelle
1.07 1.35e-08 GO:0043227 membrane-bounded organelle
1.09 1.04e-07 GO:0044446 intracellular organelle part
1.09 1.59e-07 GO:0044422 organelle part
1.16 1.17e-06 GO:0005829 cytosol
1.02 4.03e-05 GO:0044464 cell part
1.02 4.55e-05 GO:0005623 cell
1.12 7.25e-05 GO:0043234 protein complex
1.17 1.59e-04 GO:0005856 cytoskeleton
1.20 8.61e-04 GO:0044430 cytoskeletal part
1.26 1.72e-03 GO:0030054 cell junction
1.07 4.97e-03 GO:0005634 nucleus
1.28 1.00e-02 GO:0045202 synapse
1.31 1.44e-02 GO:0015629 actin cytoskeleton
1.08 1.60e-02 GO:0032991 macromolecular complex
1.13 2.58e-02 GO:0012505 endomembrane system
1.10 2.60e-02 GO:0043228 non-membrane-bounded organelle
1.10 2.60e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.11 2.71e-02 GO:0031090 organelle membrane
1.51 3.97e-02 GO:0019717 synaptosome
1.16 4.17e-02 GO:0005794 Golgi apparatus
1.28 4.95e-02 GO:0005773 vacuole

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 2.67e-15 GO:0005515 protein binding
1.03 1.24e-02 GO:0005488 binding
1.12 3.00e-02 GO:0017076 purine nucleotide binding
1.12 3.35e-02 GO:0032553 ribonucleotide binding
1.12 3.35e-02 GO:0032555 purine ribonucleotide binding
1.12 4.22e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.11 4.23e-02 GO:0000166 nucleotide binding