Motif ID: NHLH1,2.p2

Z-value: 2.960


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_1161848460.401.2e-01Click!
NHLH1chr1_+_158603480-0.194.8e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_113546841 4.628 NM_000820
GAS6
growth arrest-specific 6
chr10_+_17311283 4.281 VIM
vimentin
chr10_+_17311307 4.264 VIM
vimentin
chr10_+_17311242 4.254 VIM
vimentin
chr10_+_17311282 4.127 VIM
vimentin
chr10_+_17311347 4.118 VIM
vimentin
chr13_+_113546897 3.953 GAS6
growth arrest-specific 6
chr14_-_51605487 3.918 NID2
nidogen 2 (osteonidogen)
chr13_+_113546943 3.836 GAS6
growth arrest-specific 6
chrX_-_13866451 3.786 GPM6B
glycoprotein M6B
chr4_-_57671307 3.689 IGFBP7
insulin-like growth factor binding protein 7
chr11_-_6298284 3.581 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr14_-_51605461 3.561 NID2
nidogen 2 (osteonidogen)
chr14_-_51605515 3.448 NID2
nidogen 2 (osteonidogen)
chr9_-_35679799 3.328 TPM2
tropomyosin 2 (beta)
chr2_-_229844198 3.311 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr4_-_57671273 3.149 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr9_-_35679902 3.088 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr10_+_124211353 2.990 HTRA1
HtrA serine peptidase 1
chr7_+_129919157 2.825 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr4_-_81213207 2.750


chr2_-_37752731 2.612 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_-_1727247 2.520 PXDN
peroxidasin homolog (Drosophila)
chr12_-_21702021 2.491 LDHB
lactate dehydrogenase B
chr10_+_17311788 2.478 VIM
vimentin
chr12_-_21702000 2.471 LDHB
lactate dehydrogenase B
chr12_-_21702036 2.422 LDHB
lactate dehydrogenase B
chr11_+_86189138 2.361 NM_007173
PRSS23
protease, serine, 23
chr11_-_65841077 2.349 NM_020404
CD248
CD248 molecule, endosialin
chr13_+_113546912 2.342 GAS6
growth arrest-specific 6
chr4_-_40911212 2.318 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr15_+_72006015 2.293 LOXL1
lysyl oxidase-like 1
chr3_-_73756668 2.290 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr12_-_53099269 2.262 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_53099203 2.157 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_-_151171576 2.089 PFN2
profilin 2
chr1_+_67168470 2.043 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr7_-_130891861 2.040 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr7_-_45927263 2.000 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr7_+_17304707 1.975 NM_001621
AHR
aryl hydrocarbon receptor
chr12_-_53099277 1.940 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_+_16048047 1.925 NM_003290
TPM4
tropomyosin 4
chr1_+_28791593 1.889 NM_001193532
RAB42
RAB42, member RAS oncogene family
chr14_-_51605695 1.861 NM_007361
NID2
nidogen 2 (osteonidogen)
chr1_+_77520315 1.851 NM_174858
AK5
adenylate kinase 5
chr14_+_89933118 1.819 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chrX_-_13866565 1.815 NM_001001994
GPM6B
glycoprotein M6B
chr1_-_85703321 1.813 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr12_+_6179736 1.738 NM_001769
CD9
CD9 molecule
chr12_+_51777684 1.631 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr13_-_35603432 1.626 DCLK1
doublecortin-like kinase 1
chr21_+_46367216 1.576 COL6A2
collagen, type VI, alpha 2
chr11_+_133444175 1.572 JAM3
junctional adhesion molecule 3
chr3_-_151171190 1.530 NM_002628
NM_053024
PFN2

profilin 2

chr12_-_45759691 1.525 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr1_-_95165089 1.524 NM_001839
CNN3
calponin 3, acidic
chr19_-_63301418 1.523 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr1_+_85819004 1.519 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_15106597 1.501 NM_153321
PMP22
peripheral myelin protein 22
chr3_-_87122936 1.498 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr17_-_15106579 1.493 PMP22
peripheral myelin protein 22
chrX_-_154341451 1.482 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr10_+_124210980 1.477 NM_002775
HTRA1
HtrA serine peptidase 1
chrX_+_135057202 1.469 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr9_-_139060416 1.462 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr5_-_136862786 1.460 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr4_+_174326464 1.432 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chrX_+_153767803 1.430 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr3_+_8518508 1.424 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr2_-_227371698 1.397 NM_005544
IRS1
insulin receptor substrate 1
chr12_-_74710741 1.381 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_-_191422346 1.379 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr19_+_43446937 1.367 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chrX_-_37964924 1.352 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr8_-_98359248 1.316 TSPYL5
TSPY-like 5
chr1_-_31154023 1.307 NM_014654
SDC3
syndecan 3
chr2_-_1727324 1.301 PXDN
peroxidasin homolog (Drosophila)
chr8_-_41286088 1.298 NM_003012
SFRP1
secreted frizzled-related protein 1
chr20_+_19818209 1.296 NM_018993
RIN2
Ras and Rab interactor 2
chr19_+_43447078 1.295 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr7_+_98084531 1.292 NM_002523
NPTX2
neuronal pentraxin II
chr11_+_44543716 1.275 NM_001024844
NM_002231
CD82

CD82 molecule

chr5_+_102229612 1.237 PAM
peptidylglycine alpha-amidating monooxygenase
chr14_+_89933055 1.233 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr2_-_1727292 1.229 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_-_59020875 1.227 JUN
jun proto-oncogene
chr3_+_49034494 1.214 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr9_+_123070234 1.210 GSN
gelsolin
chr6_-_109883635 1.201 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_-_56817717 1.200 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_-_98359347 1.186 NM_033512
TSPYL5
TSPY-like 5
chrX_-_13866366 1.177


chr6_-_109883639 1.177 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr12_+_4300607 1.173 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr1_+_163867057 1.168 NM_004528
MGST3
microsomal glutathione S-transferase 3
chr3_-_45162865 1.165 CDCP1
CUB domain containing protein 1
chr20_-_57015698 1.165 NM_001336
CTSZ
cathepsin Z
chr5_-_175776137 1.164 NM_001834
NM_007097
CLTB

clathrin, light chain B

chrX_+_80344253 1.158 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_+_51474531 1.158 NM_014372
RNF11
ring finger protein 11
chr6_+_129245978 1.158 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr19_+_16048266 1.150 TPM4
tropomyosin 4
chr19_+_16048306 1.149 TPM4
tropomyosin 4
chr6_-_46566969 1.147 RCAN2
regulator of calcineurin 2
chr3_+_49034050 1.141 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr4_-_120769275 1.141 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr2_+_46779827 1.140 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr6_-_139737432 1.117 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr12_-_67613213 1.114 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr1_-_94475840 1.114 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chrX_+_152699616 1.109 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr6_-_139737477 1.106 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr19_+_16048315 1.105 TPM4
tropomyosin 4
chr3_-_45162901 1.089 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr11_+_822965 1.085 CD151
CD151 molecule (Raph blood group)
chr2_+_202607554 1.077 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr8_+_37773991 1.073 GPR124
G protein-coupled receptor 124
chr1_-_199732323 1.064 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr11_+_823007 1.060 CD151
CD151 molecule (Raph blood group)
chr11_+_822909 1.060 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr9_+_113433364 1.046 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chrX_+_73557809 1.042 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr3_-_45162847 1.039 CDCP1
CUB domain containing protein 1
chr8_+_37773564 1.039 GPR124
G protein-coupled receptor 124
chr8_+_37773915 1.037 GPR124
G protein-coupled receptor 124
chr21_+_25933459 1.030 NM_021219
JAM2
junctional adhesion molecule 2
chr21_+_45318861 1.025 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr15_-_21483457 1.020 NDN
necdin homolog (mouse)
chr14_-_29466562 1.018 NM_002742
PRKD1
protein kinase D1
chr7_+_65307816 1.015 TPST1
tyrosylprotein sulfotransferase 1
chr12_-_102968044 1.013 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr6_-_109883525 0.996 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr12_-_54409107 0.991 NM_001040034
NM_001780
CD63

CD63 molecule

chr12_-_102967828 0.983 GLT8D2
glycosyltransferase 8 domain containing 2
chr9_+_89530896 0.983 CTSL1
cathepsin L1
chr12_-_75796898 0.978 NM_001321
CSRP2
cysteine and glycine-rich protein 2
chr5_+_102229425 0.975 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr11_-_102174032 0.973 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr6_-_139737042 0.969 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr1_-_94475504 0.969 ARHGAP29
Rho GTPase activating protein 29
chr1_+_51474583 0.966 RNF11
ring finger protein 11
chr7_-_526005 0.964 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr9_+_89530838 0.962 CTSL1
cathepsin L1
chr12_+_47498778 0.962 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr2_-_202024472 0.961 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr7_-_124192265 0.959 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_+_191818124 0.955 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr13_-_109757442 0.953 NM_001845
COL4A1
collagen, type IV, alpha 1
chr1_-_154913712 0.952 NM_006617
NES
nestin
chr14_-_74148422 0.949 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr6_+_139497933 0.948 NM_016217
HECA
headcase homolog (Drosophila)
chr2_-_175578156 0.946 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr4_+_78298326 0.945 CCNG2
cyclin G2
chr18_+_9324820 0.943 TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr11_-_124871258 0.933 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr15_-_46725087 0.929 NM_000138
FBN1
fibrillin 1
chr5_-_175775966 0.925 CLTB
clathrin, light chain B
chr3_-_126088530 0.925 ITGB5
integrin, beta 5
chr1_-_43691932 0.922 HYI
hydroxypyruvate isomerase (putative)
chr18_+_9324762 0.921 NM_020648
TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr12_-_123023312 0.919 CCDC92
coiled-coil domain containing 92
chr15_+_61127367 0.918 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr13_-_44048391 0.917 TSC22D1
TSC22 domain family, member 1
chr22_+_22652248 0.914 NM_000854
GSTT2
GSTT2B
glutathione S-transferase theta 2
glutathione S-transferase theta 2B (gene/pseudogene)
chr19_+_43447262 0.914 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr8_+_31616809 0.908 NM_013962
NRG1
neuregulin 1
chr1_-_199613427 0.907 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr7_+_44754978 0.906 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr2_-_235070431 0.906 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr2_-_55131202 0.904 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr9_+_89530793 0.897 NM_001912
NM_145918
CTSL1

cathepsin L1

chr7_+_55054416 0.896 EGFR
epidermal growth factor receptor
chr2_+_202949289 0.889 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr9_-_139060377 0.889 NPDC1
neural proliferation, differentiation and control, 1
chrX_-_106905545 0.887 TSC22D3
TSC22 domain family, member 3
chr9_+_124173143 0.882 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_139060285 0.875 NPDC1
neural proliferation, differentiation and control, 1
chr3_-_55490401 0.872 WNT5A
wingless-type MMTV integration site family, member 5A
chr3_-_147361465 0.868 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr13_-_35603513 0.866 NM_004734
DCLK1
doublecortin-like kinase 1
chr12_+_77782719 0.866 SYT1
synaptotagmin I
chr1_-_201420927 0.864 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr2_+_5750229 0.860 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr2_+_238060602 0.860 NM_001042467
NM_024101
MLPH

melanophilin

chr11_-_35503720 0.859 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr4_+_158216631 0.859 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr1_-_199613406 0.857 TNNT2
troponin T type 2 (cardiac)
chr4_-_57671112 0.845 IGFBP7
insulin-like growth factor binding protein 7
chr8_+_70567581 0.842 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr7_+_102340579 0.841 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr5_+_17270474 0.841 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr13_+_48967746 0.838 NM_001040443
PHF11
PHD finger protein 11
chr21_-_45118037 0.835 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chrX_-_153767625 0.835 NM_019863
F8
coagulation factor VIII, procoagulant component
chr2_-_55130925 0.834 RTN4
reticulon 4
chr1_+_200584421 0.822 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr11_+_12355600 0.815 NM_018222
PARVA
parvin, alpha
chr1_+_84316217 0.813 NM_002731
NM_207578
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr13_+_114018459 0.811 NM_001078645
NM_003903
CDC16

cell division cycle 16 homolog (S. cerevisiae)

chr1_-_113051545 0.810 NM_001042678
NM_175744
RHOC

ras homolog gene family, member C


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 3.47e-05 GO:0048869 cellular developmental process
1.42 4.87e-05 GO:0048468 cell development
1.27 7.74e-05 GO:0030154 cell differentiation
1.41 1.34e-04 GO:0022008 neurogenesis
1.18 3.36e-04 GO:0032502 developmental process
1.20 3.45e-04 GO:0048856 anatomical structure development
1.30 5.01e-04 GO:0009653 anatomical structure morphogenesis
1.29 8.47e-04 GO:0007399 nervous system development
1.40 8.58e-04 GO:0048699 generation of neurons
1.18 1.19e-03 GO:0007275 multicellular organismal development
1.49 3.43e-03 GO:0048858 cell projection morphogenesis
1.53 4.18e-03 GO:0007409 axonogenesis
1.52 5.00e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.51 5.84e-03 GO:0048812 neuron projection morphogenesis
1.48 6.01e-03 GO:0032990 cell part morphogenesis
1.18 9.29e-03 GO:0048731 system development
1.46 1.79e-02 GO:0000904 cell morphogenesis involved in differentiation
1.41 1.79e-02 GO:0030030 cell projection organization
1.24 2.23e-02 GO:0023051 regulation of signaling
1.42 2.24e-02 GO:0000902 cell morphogenesis
1.46 2.35e-02 GO:0031175 neuron projection development
1.40 2.93e-02 GO:0032989 cellular component morphogenesis
1.38 3.05e-02 GO:0030182 neuron differentiation
1.12 3.76e-02 GO:0032501 multicellular organismal process
1.29 3.88e-02 GO:0010646 regulation of cell communication
1.41 4.32e-02 GO:0048666 neuron development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.76e-05 GO:0005737 cytoplasm
1.23 1.97e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 7.04e-04 GO:0003779 actin binding
1.39 3.86e-02 GO:0008092 cytoskeletal protein binding