Motif ID: NKX2-1,4.p2

Z-value: 1.006


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_360586480.361.7e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_11966464 3.080 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr21_-_14840506 2.546 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chrX_+_78087484 2.221 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr17_-_26665213 1.737 EVI2B
ecotropic viral integration site 2B
chrX_-_154216929 1.684 NM_001289
CLIC2
chloride intracellular channel 2
chr17_-_26665220 1.561 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 1.351 EVI2B
ecotropic viral integration site 2B
chrX_+_48427103 1.256 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_59979857 1.246 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_+_32489426 0.982 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr5_-_88155360 0.876 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_-_51887266 0.795 NM_000889
ITGB7
integrin, beta 7
chr19_-_6621598 0.762 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr17_-_26665194 0.755 EVI2B
ecotropic viral integration site 2B
chr19_-_6621078 0.753 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr2_-_88946767 0.743


chr7_-_7724762 0.690 NM_002947
RPA3
replication protein A3, 14kDa
chr3_-_143230124 0.686 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_+_22646229 0.684 NM_177553
GAS2
growth arrest-specific 2
chr1_-_158948176 0.642 NM_001778
CD48
CD48 molecule
chr2_+_33554824 0.640 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_159899528 0.564 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_+_143603368 0.555 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr14_+_63752424 0.525 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr15_-_53350383 0.506 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr12_-_101115677 0.500 NM_002674
PMCH
pro-melanin-concentrating hormone
chr2_+_143603439 0.491 ARHGAP15
Rho GTPase activating protein 15
chr15_-_53349775 0.489 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr13_-_98757634 0.470 NM_004951
GPR183
G protein-coupled receptor 183
chr12_-_51887318 0.441 ITGB7
integrin, beta 7
chr18_-_44723116 0.402 NM_001190823
SMAD7
SMAD family member 7
chr5_+_156752739 0.399 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_+_65009986 0.385 MAP2K6
mitogen-activated protein kinase kinase 6
chr6_+_101953389 0.371 GRIK2
glutamate receptor, ionotropic, kainate 2
chr1_+_196874759 0.367 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr4_-_176970407 0.365 GPM6A
glycoprotein M6A
chr14_+_75058518 0.363 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr10_-_11614279 0.361 NM_001080491
USP6NL
USP6 N-terminal like
chrX_-_137649180 0.360 NM_033642
FGF13
fibroblast growth factor 13
chr12_+_25096755 0.349 LRMP
lymphoid-restricted membrane protein
chr19_-_11549508 0.342 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr5_-_88235624 0.337 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chrX_-_33139349 0.329 NM_004006
DMD
dystrophin
chr5_-_176769094 0.322 F12
coagulation factor XII (Hageman factor)
chr4_+_102954005 0.316 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr6_-_88917600 0.312 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr3_-_120761092 0.311 NM_005191
CD80
CD80 molecule
chr2_+_161980865 0.303 NM_006593
TBR1
T-box, brain, 1
chrX_-_72351381 0.301 NAP1L2
nucleosome assembly protein 1-like 2
chr6_-_41811916 0.299 NM_001167827
TFEB
transcription factor EB
chr1_-_158883666 0.297 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chrX_-_48655978 0.294 PIM2
pim-2 oncogene
chr1_+_159817752 0.286 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_+_196874867 0.280 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_+_130485926 0.270 SET
SET nuclear oncogene
chr9_+_130485754 0.261 NM_001122821
SET
SET nuclear oncogene
chr2_+_105320440 0.255 NM_024093
C2orf49
chromosome 2 open reading frame 49
chr6_+_26266311 0.253 NM_021063
NM_138720
HIST1H2BD

histone cluster 1, H2bd

chr7_+_129634935 0.250 NM_145268
C7orf45
chromosome 7 open reading frame 45
chrX_-_72351392 0.249 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr15_+_79304694 0.243 NM_172217
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chrX_-_110542040 0.242 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chrX_+_70682204 0.240 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr7_-_104696678 0.228 NM_182691
SRPK2
SRSF protein kinase 2
chr2_-_170138558 0.228 NM_024622
FASTKD1
FAST kinase domains 1
chrX_-_100920493 0.224 GK
glycerol kinase
chrX_+_49047068 0.223 NM_001098413
GAGE10
G antigen 10
chr1_-_118123033 0.223


chr4_-_123596921 0.222 NM_000586
IL2
interleukin 2
chr7_-_16471817 0.222 NM_015464
SOSTDC1
sclerostin domain containing 1
chr12_-_7739591 0.219 NM_020634
GDF3
growth differentiation factor 3
chr1_-_108032645 0.215 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr12_+_111900650 0.215 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr10_+_114125003 0.211 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_94669547 0.209 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr19_-_60458915 0.207 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr6_-_32268267 0.202 GPSM3
G-protein signaling modulator 3
chr1_-_9052207 0.199 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr14_+_75058591 0.198 BATF
basic leucine zipper transcription factor, ATF-like
chr3_+_191588354 0.196 NM_006580
CLDN16
claudin 16
chr10_+_11087280 0.196 CELF2
CUGBP, Elav-like family member 2
chr4_+_114433551 0.189 ANK2
ankyrin 2, neuronal
chr2_-_175170674 0.187 WIPF1
WAS/WASL interacting protein family, member 1
chr1_+_40977092 0.185 NFYC
nuclear transcription factor Y, gamma
chr7_+_38984133 0.185 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr1_+_100089118 0.184 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chrX_+_119622570 0.181 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr5_-_94442941 0.180 MCTP1
multiple C2 domains, transmembrane 1
chr19_+_42689881 0.179 ZNF793
zinc finger protein 793
chrX_+_48427137 0.179 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_-_176769141 0.177 NM_000505
F12
coagulation factor XII (Hageman factor)
chrX_-_72351348 0.173 NAP1L2
nucleosome assembly protein 1-like 2
chr3_-_188492163 0.171 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr10_+_70650064 0.168 NM_025130
HKDC1
hexokinase domain containing 1
chr19_-_11549441 0.166 ACP5
acid phosphatase 5, tartrate resistant
chr10_+_112334066 0.166 SMC3
structural maintenance of chromosomes 3
chr19_-_51979838 0.161 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr4_-_123761615 0.157 NM_021803
IL21
interleukin 21
chr18_+_19286784 0.156 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr21_+_37714470 0.155 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr2_-_74235860 0.153


chr2_+_102401580 0.150 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr8_-_30826074 0.146 NM_031271
TEX15
testis expressed 15
chr17_-_64649608 0.144 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chrX_+_64625339 0.144 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr3_+_89239363 0.143 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr1_-_9052253 0.142 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr6_-_155818728 0.136 NM_015718
NOX3
NADPH oxidase 3
chr8_+_124263932 0.136 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr3_-_57209319 0.134 NM_003865
HESX1
HESX homeobox 1
chr12_+_12769985 0.134 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr8_-_110726921 0.131 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr3_+_89239494 0.130 EPHA3
EPH receptor A3
chr13_+_33290254 0.128 RFC3
replication factor C (activator 1) 3, 38kDa
chr2_+_28469864 0.125 FOSL2
FOS-like antigen 2
chr6_+_5206211 0.123 FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr2_-_191723996 0.123 STAT4
signal transducer and activator of transcription 4
chr1_-_229627412 0.121 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr5_-_160211623 0.121 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_-_26266571 0.120 NM_032588
TRIM63
tripartite motif containing 63
chr1_-_245120900 0.119 AHCTF1
AT hook containing transcription factor 1
chr5_-_147996769 0.118 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr17_+_7846636 0.117 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chrX_-_131401319 0.116 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr1_-_149698272 0.114 POGZ
pogo transposable element with ZNF domain
chr4_-_77147625 0.114 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr18_-_3001944 0.113 NM_014646
LPIN2
lipin 2
chr18_+_70317548 0.112 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr5_-_142795269 0.110 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr19_-_10152056 0.110


chr11_+_118463906 0.110 NM_001024382
HMBS
hydroxymethylbilane synthase
chr15_-_23204887 0.109 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr7_-_107230867 0.108 NM_000111
SLC26A3
solute carrier family 26, member 3
chr5_+_161427225 0.107 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr4_+_111053488 0.105 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr17_-_3407780 0.102 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr13_-_25687062 0.102 RNF6
ring finger protein (C3H2C3 type) 6
chr13_-_74799898 0.098 TBC1D4
TBC1 domain family, member 4
chr18_-_59137488 0.097 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr3_+_171183203 0.096 SEC62
SEC62 homolog (S. cerevisiae)
chr4_+_22303645 0.096 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr1_-_158815850 0.095 CD84
CD84 molecule
chr20_+_2224612 0.094 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr5_+_140215778 0.092 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr16_+_3002457 0.091 NM_020982
CLDN9
claudin 9
chr2_-_179024002 0.090 NM_003690
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr8_-_28803341 0.090 NM_001172562
INTS9
integrator complex subunit 9
chr19_+_750281 0.089 PTBP1
polypyrimidine tract binding protein 1
chr8_+_7742811 0.088 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr7_+_50318801 0.087 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr3_-_185085325 0.087 PARL
presenilin associated, rhomboid-like
chrX_-_48101044 0.086 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr6_+_35373632 0.086 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr10_+_69539255 0.084 NM_032578
MYPN
myopalladin
chr2_-_191724169 0.084 NM_003151
STAT4
signal transducer and activator of transcription 4
chrX_+_48978875 0.084 CCDC22
coiled-coil domain containing 22
chr19_-_60360768 0.084 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr13_+_81162030 0.081


chr19_+_39355151 0.080 NM_001114093
NM_015578
LSM14A

LSM14A, SCD6 homolog A (S. cerevisiae)

chr15_-_72287447 0.080 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr18_+_54489597 0.079 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chrX_+_48978870 0.079 NM_014008
CCDC22
coiled-coil domain containing 22
chr6_+_45404031 0.079 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr5_+_150020595 0.079 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr7_+_28692122 0.077 NM_001011666
CREB5
cAMP responsive element binding protein 5
chrX_+_119622012 0.077 MCTS1
malignant T cell amplified sequence 1
chr9_-_94226380 0.076 NM_005014
OMD
osteomodulin
chr15_-_23201740 0.075 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr17_-_53961709 0.074 NM_004574
SEPT4
septin 4
chr3_+_171560104 0.072 NM_001145097
SKIL
SKI-like oncogene
chrX_+_48529905 0.072 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr16_+_31446703 0.072 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr1_+_221168388 0.070 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr13_+_110637173 0.069 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_-_102331643 0.068 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr2_+_105320247 0.068 C2orf49
chromosome 2 open reading frame 49
chr6_+_33365445 0.067 PFDN6
prefoldin subunit 6
chr12_-_52980914 0.066 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_+_117452936 0.065 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr10_+_80942362 0.065 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr10_-_116517945 0.064 ABLIM1
actin binding LIM protein 1
chr19_+_50196526 0.063 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr20_-_33706532 0.062 RBM12
RNA binding motif protein 12
chr1_-_42574116 0.061 NM_001198850
FOXJ3
forkhead box J3
chr1_+_151498802 0.061 NM_000427
LOR
loricrin
chr21_-_31995972 0.061 SCAF4
SR-related CTD-associated factor 4
chr2_+_161701711 0.058 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr3_-_17757402 0.057 NM_014744
TBC1D5
TBC1 domain family, member 5
chr12_+_15590552 0.057 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_+_50344550 0.057 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_+_1396239 0.057 NM_000547
NM_175719
TPO

thyroid peroxidase

chr12_+_54700955 0.056 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr11_+_117452995 0.055 TMPRSS4
transmembrane protease, serine 4
chr2_+_1397186 0.054 NM_175721
NM_175722
TPO

thyroid peroxidase

chr12_-_85756766 0.054 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_-_49041764 0.053 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chrX_+_70281405 0.053 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr4_-_72868598 0.052 NM_000583
GC
group-specific component (vitamin D binding protein)
chr12_-_52980984 0.052 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_+_62195710 0.052 C11orf83
chromosome 11 open reading frame 83

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.24 2.08e-06 GO:0046649 lymphocyte activation
4.41 1.87e-05 GO:0045321 leukocyte activation
2.84 1.66e-03 GO:0001775 cell activation
6.81 2.57e-03 GO:0042113 B cell activation
10.33 5.22e-03 GO:0046651 lymphocyte proliferation
1.42 7.23e-03 GO:0032501 multicellular organismal process
9.69 8.30e-03 GO:0032943 mononuclear cell proliferation
1.78 8.60e-03 GO:0048513 organ development
9.39 1.03e-02 GO:0070661 leukocyte proliferation
1.35 1.47e-02 GO:0050896 response to stimulus
1.66 2.54e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.34 2.11e-02 GO:0031968 organelle outer membrane
1.42 2.77e-02 GO:0005886 plasma membrane
4.18 2.92e-02 GO:0019867 outer membrane
1.40 4.85e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.70 3.15e-02 GO:0004871 signal transducer activity
1.70 3.15e-02 GO:0060089 molecular transducer activity
1.81 3.45e-02 GO:0004872 receptor activity