Motif ID: SP1.p2

Z-value: 1.361


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_52060689-0.421.0e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_13035102 2.259 NM_006094
DLC1
deleted in liver cancer 1
chr3_-_187025501 1.734 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr11_+_46359878 1.601 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr17_-_74432800 1.457 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_13044467 1.431 NM_015987
HEBP1
heme binding protein 1
chr11_+_46359855 1.380 MDK
midkine (neurite growth-promoting factor 2)
chr11_+_46359781 1.367 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr11_-_2907169 1.362 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr17_-_74432671 1.313 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_2916980 1.297 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr17_-_72218661 1.283 MXRA7
matrix-remodelling associated 7
chr12_-_13044314 1.229 HEBP1
heme binding protein 1
chr6_-_31805547 1.221 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr19_+_50041400 1.203 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_-_20685314 1.182 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_-_223907283 1.178 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr12_-_105056577 1.172 NUAK1
NUAK family, SNF1-like kinase, 1
chr11_+_46359821 1.171 MDK
midkine (neurite growth-promoting factor 2)
chr17_-_74433048 1.160 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr11_+_46359836 1.151 MDK
midkine (neurite growth-promoting factor 2)
chr11_-_86343859 1.136 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr2_+_10101081 1.126 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr12_-_123023052 1.110 NM_025140
CCDC92
coiled-coil domain containing 92
chr2_+_235525355 1.095 NM_014521
SH3BP4
SH3-domain binding protein 4
chr10_+_134201262 1.087 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr19_+_50041232 1.080 NM_001042724
NM_002856
PVRL2

poliovirus receptor-related 2 (herpesvirus entry mediator B)

chr10_-_15250616 1.076 NM_004808
NMT2
N-myristoyltransferase 2
chr10_-_80875097 1.063 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr3_-_187025438 1.053 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr19_+_50041424 1.024 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr14_-_52487558 1.024 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr19_-_11169184 1.020 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr19_+_50041387 1.015 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_+_822965 0.986 CD151
CD151 molecule (Raph blood group)
chr6_+_2945025 0.984 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr11_+_823007 0.948 CD151
CD151 molecule (Raph blood group)
chr11_-_11987198 0.944 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr21_+_45649429 0.942 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr5_+_71438796 0.927 NM_005909
MAP1B
microtubule-associated protein 1B
chr11_-_11987115 0.911 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr3_-_43638471 0.906 NM_018075
ANO10
anoctamin 10
chr22_-_34754343 0.903 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr3_-_43638425 0.902 ANO10
anoctamin 10
chr7_+_73506333 0.900 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chr7_+_73506172 0.896 GTF2IRD1
GTF2I repeat domain containing 1
chr20_-_23566325 0.896 NM_000099
CST3
cystatin C
chr5_-_176832476 0.887 NM_080881
DBN1
drebrin 1
chr5_-_176833259 0.878 NM_004395
DBN1
drebrin 1
chr11_+_129445057 0.848 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_-_11987414 0.848 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr1_+_178390646 0.842 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr8_-_11762918 0.835 CTSB
cathepsin B
chr6_+_17501589 0.831 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr17_-_72218535 0.827 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr22_+_21559959 0.815 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr8_-_11763023 0.803 CTSB
cathepsin B
chr6_-_31805932 0.803 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr3_-_125085834 0.802 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr12_-_123023312 0.800 CCDC92
coiled-coil domain containing 92
chr3_-_130807865 0.795 NM_015103
PLXND1
plexin D1
chr21_+_45649719 0.787


chr5_-_176833197 0.780 DBN1
drebrin 1
chr6_-_31806012 0.780 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr14_-_52487386 0.769 FERMT2
fermitin family member 2
chr14_-_106249999 0.764 IGHA1
immunoglobulin heavy constant alpha 1
chr11_+_46358909 0.764 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr17_-_78199384 0.752 NM_019613
WDR45L
WDR45-like
chr1_+_178390636 0.738 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr11_+_12652427 0.736 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr2_-_36678657 0.731 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr11_+_822909 0.729 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr22_+_21340757 0.726


chr9_-_130912728 0.719 NM_000755
CRAT
carnitine O-acetyltransferase
chr1_+_178390529 0.714 NM_001004128
NM_002826
QSOX1

quiescin Q6 sulfhydryl oxidase 1

chr21_-_43368963 0.714 NM_000071
CBS
cystathionine-beta-synthase
chr11_-_61415429 0.709 NM_021727
FADS3
fatty acid desaturase 3
chr17_-_829655 0.706 NM_022463
NXN
nucleoredoxin
chr1_-_151873191 0.704 NM_001024210
S100A13
S100 calcium binding protein A13
chr1_+_178390654 0.698 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr19_+_54708247 0.697 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_32665409 0.697 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr8_-_11763004 0.692 CTSB
cathepsin B
chr1_+_178390660 0.687 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr7_+_73506047 0.687 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr11_+_129444877 0.685 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr19_+_54708312 0.683 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr21_+_46226072 0.683 NM_001848
COL6A1
collagen, type VI, alpha 1
chr2_-_183610992 0.678 NCKAP1
NCK-associated protein 1
chr2_-_158440587 0.675 NM_001111067
ACVR1
activin A receptor, type I
chr6_-_52549673 0.671 TRAM2
translocation associated membrane protein 2
chr10_-_126839000 0.666 CTBP2
C-terminal binding protein 2
chr15_-_27901828 0.666 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr22_+_21116283 0.665


chr19_+_59385930 0.664 NM_024075
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr1_+_93686154 0.662 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr7_-_130891861 0.658 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr6_+_33151703 0.653 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_-_45242808 0.653 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr11_-_110755112 0.653 POU2AF1
POU class 2 associating factor 1
chr9_-_130912603 0.652 CRAT
carnitine O-acetyltransferase
chr6_-_2916786 0.652 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr19_-_18409788 0.651 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr8_-_11763031 0.650 CTSB
cathepsin B
chr10_-_126839056 0.646 NM_001329
CTBP2
C-terminal binding protein 2
chr19_+_3045528 0.636 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr3_-_45242624 0.635 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr11_+_129444997 0.634 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_22136263 0.629 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr5_+_141468498 0.627 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr4_-_158111995 0.627 NM_016205
PDGFC
platelet derived growth factor C
chr2_-_218551786 0.624 TNS1
tensin 1
chrX_-_101658297 0.621 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr11_-_2863536 0.620 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr15_-_20637731 0.618 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr1_-_225572419 0.618 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr14_-_105163301 0.616 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr1_+_178390598 0.615 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr7_-_143230096 0.615 NM_014719
FAM115A
family with sequence similarity 115, member A
chr22_+_21370394 0.611 IGL@
immunoglobulin lambda locus
chr6_-_33149244 0.611 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr1_-_52228880 0.609 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr3_+_156280338 0.605 NM_007287
MME
membrane metallo-endopeptidase
chr4_-_177950658 0.603 NM_005429
VEGFC
vascular endothelial growth factor C
chr11_+_129445017 0.599 APLP2
amyloid beta (A4) precursor-like protein 2
chrX_-_34585287 0.597 NM_031442
TMEM47
transmembrane protein 47
chr3_+_123526700 0.596 NM_005213
CSTA
cystatin A (stefin A)
chr14_-_105182025 0.587


chr12_+_6424293 0.586 NM_001242
CD27
CD27 molecule
chr19_-_54835162 0.585 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr10_+_94439658 0.585 NM_002729
HHEX
hematopoietically expressed homeobox
chr16_-_63713485 0.582 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr10_-_725522 0.582 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr2_+_24126140 0.579 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr1_+_181259317 0.579


chr18_+_3439972 0.577 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr14_-_105181939 0.575 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr14_-_68515791 0.570 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr5_-_179166378 0.570 NM_014275
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr17_-_1566223 0.570 C17orf91
chromosome 17 open reading frame 91
chr1_+_243200275 0.569 EFCAB2
EF-hand calcium binding domain 2
chr9_-_73573121 0.569 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr14_-_105308639 0.567


chr11_-_11987458 0.566 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr7_+_93861808 0.565 NM_000089
COL1A2
collagen, type I, alpha 2
chr2_+_24126087 0.563 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr1_+_181258952 0.561 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr18_-_24010944 0.561 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_-_95165037 0.555 CNN3
calponin 3, acidic
chr19_+_3045266 0.555 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr16_-_87450734 0.553 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr14_-_105308720 0.553 IGHM
immunoglobulin heavy constant mu
chr7_-_1465487 0.548 MICALL2
MICAL-like 2
chr2_+_20510312 0.547 NM_004040
RHOB
ras homolog gene family, member B
chr17_-_60088637 0.544 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr21_-_43369492 0.543 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr14_-_105280425 0.540 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_15875932 0.534 NM_015199
ANKRD28
ankyrin repeat domain 28
chr7_-_50828608 0.533 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr14_-_68515525 0.532 ACTN1
actinin, alpha 1
chr3_+_12813170 0.532 NM_001162499
NM_012298
CAND2

cullin-associated and neddylation-dissociated 2 (putative)

chr4_-_1156533 0.532 NM_012445
SPON2
spondin 2, extracellular matrix protein
chr20_+_30813851 0.530 NM_006892
NM_175848
NM_175849
DNMT3B


DNA (cytosine-5-)-methyltransferase 3 beta


chr17_-_1335763 0.529 NM_001080950
MYO1C
myosin IC
chr10_-_62373828 0.529 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr14_+_95575319 0.523 C14orf132
chromosome 14 open reading frame 132
chr6_-_52549774 0.522 NM_012288
TRAM2
translocation associated membrane protein 2
chr6_+_37245860 0.521 NM_002648
PIM1
pim-1 oncogene
chr19_-_60350122 0.521 TNNT1
troponin T type 1 (skeletal, slow)
chr11_+_129445002 0.520 APLP2
amyloid beta (A4) precursor-like protein 2
chr19_+_54708302 0.519 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_+_105012106 0.518 NM_001312
CRIP2
cysteine-rich protein 2
chr10_+_121400741 0.515 NM_004281
BAG3
BCL2-associated athanogene 3
chr14_-_105182159 0.513 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr20_+_11819364 0.512 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr11_-_65396775 0.511 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chrX_+_54852217 0.511 NM_201222
MAGED2
melanoma antigen family D, 2
chr22_-_35875890 0.509 NM_000878
IL2RB
interleukin 2 receptor, beta
chr8_-_11763037 0.507 NM_001908
NM_147780
NM_147781
NM_147782
NM_147783
CTSB




cathepsin B




chr12_-_51132129 0.507 NM_005555
KRT6B
keratin 6B
chr17_+_77528699 0.506 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr5_-_179431204 0.505 RNF130
ring finger protein 130
chr9_+_102275455 0.505 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chrX_-_153428621 0.502 G6PD
glucose-6-phosphate dehydrogenase
chr5_-_16989371 0.499 NM_012334
MYO10
myosin X
chrX_-_17789276 0.497 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr14_-_64508547 0.497 NM_198686
RAB15
RAB15, member RAS onocogene family
chr5_+_141468569 0.495 NDFIP1
Nedd4 family interacting protein 1
chr16_-_63713382 0.494 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chrX_+_9392980 0.493 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr22_+_21495273 0.493


chr7_-_150847529 0.493 RHEB
Ras homolog enriched in brain
chr17_-_38427853 0.493 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr8_-_25371858 0.492 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr19_-_60350118 0.491 TNNT1
troponin T type 1 (skeletal, slow)
chr1_-_84928473 0.488 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr14_-_29466562 0.487 NM_002742
PRKD1
protein kinase D1
chr19_-_59385265 0.487 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr16_-_63713466 0.486 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_+_46779553 0.486 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr17_-_38427928 0.485 VAT1
vesicle amine transport protein 1 homolog (T. californica)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 9.71e-06 GO:0044260 cellular macromolecule metabolic process
1.20 1.47e-03 GO:0048468 cell development
1.10 3.19e-03 GO:0016043 cellular component organization
1.11 4.05e-03 GO:0071842 cellular component organization at cellular level
1.11 4.19e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.09 4.20e-03 GO:0071840 cellular component organization or biogenesis
1.06 5.75e-03 GO:0044237 cellular metabolic process
1.19 1.40e-02 GO:0048699 generation of neurons
1.18 1.45e-02 GO:0022008 neurogenesis
1.11 1.80e-02 GO:0044267 cellular protein metabolic process
1.11 2.26e-02 GO:0048523 negative regulation of cellular process
1.13 4.54e-02 GO:0009653 anatomical structure morphogenesis
1.10 4.75e-02 GO:0048519 negative regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 9.40e-21 GO:0005622 intracellular
1.07 6.99e-20 GO:0044424 intracellular part
1.08 2.40e-17 GO:0043229 intracellular organelle
1.08 2.64e-17 GO:0043226 organelle
1.08 1.52e-14 GO:0043227 membrane-bounded organelle
1.08 1.98e-14 GO:0043231 intracellular membrane-bounded organelle
1.08 1.96e-13 GO:0005737 cytoplasm
1.10 3.34e-09 GO:0044446 intracellular organelle part
1.09 3.44e-09 GO:0044444 cytoplasmic part
1.09 6.14e-09 GO:0044422 organelle part
1.03 3.15e-08 GO:0044464 cell part
1.03 3.70e-08 GO:0005623 cell
1.09 6.27e-08 GO:0005634 nucleus
1.15 2.17e-07 GO:0044428 nuclear part
1.14 3.43e-06 GO:0005829 cytosol
1.13 3.57e-06 GO:0043228 non-membrane-bounded organelle
1.13 3.57e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.15 1.29e-05 GO:0031981 nuclear lumen
1.13 1.44e-05 GO:0070013 intracellular organelle lumen
1.13 4.97e-05 GO:0043233 organelle lumen
1.12 5.71e-05 GO:0031974 membrane-enclosed lumen
1.10 2.36e-03 GO:0043234 protein complex
1.24 3.64e-03 GO:0005730 nucleolus
1.21 3.94e-03 GO:0015630 microtubule cytoskeleton
1.14 5.36e-03 GO:0005856 cytoskeleton
1.16 1.59e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.06 3.46e-04 GO:0005515 protein binding
1.24 1.72e-02 GO:0019904 protein domain specific binding
1.10 3.68e-02 GO:0000166 nucleotide binding