Motif ID: SREBF1,2.p2

Z-value: 2.242


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF2chr22_+_405590530.572.1e-02Click!
SREBF1chr17_-_17681034,
chr17_-_17681013
-0.562.3e-02Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_34107087 4.558 HMOX1
heme oxygenase (decycling) 1
chr1_+_181871830 4.479 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr20_+_43953428 4.381 CTSA
cathepsin A
chr20_+_43953372 4.368 CTSA
cathepsin A
chr17_-_44043361 4.183 NM_004502
HOXB7
homeobox B7
chr20_+_43953606 3.888 CTSA
cathepsin A
chr12_-_47604930 3.606 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr5_-_150517499 3.397 ANXA6
annexin A6
chr22_+_34107051 3.397 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr20_+_43953331 3.394 CTSA
cathepsin A
chr15_-_70455355 3.004 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr1_-_152459506 2.995 C1orf43
chromosome 1 open reading frame 43
chr1_+_11788827 2.967 CLCN6
chloride channel 6
chr17_+_75689985 2.844 GAA
glucosidase, alpha; acid
chr1_-_152459667 2.837 C1orf43
chromosome 1 open reading frame 43
chrX_-_15783015 2.835 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr7_+_149696792 2.797 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr5_-_150517454 2.791 ANXA6
annexin A6
chr16_-_5023934 2.754 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr16_-_5023914 2.720 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr15_-_70455153 2.649 HEXA
hexosaminidase A (alpha polypeptide)
chr20_+_43952997 2.606 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr17_-_44043278 2.554 HOXB7
homeobox B7
chr19_+_54149963 2.538 BAX
BCL2-associated X protein
chr19_+_54149843 2.488 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr19_+_54149941 2.471 BAX
BCL2-associated X protein
chr1_-_159459999 2.345 NM_001643
APOA2
apolipoprotein A-II
chr17_-_44042924 2.336 HOXB7
homeobox B7
chr16_-_5023562 2.331 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr9_-_19117462 2.324 PLIN2
perilipin 2
chr6_+_87921980 2.319 NM_015021
ZNF292
zinc finger protein 292
chr5_-_150517528 2.295 NM_001155
ANXA6
annexin A6
chr17_+_75689894 2.253 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr9_-_19117494 2.226 NM_001122
PLIN2
perilipin 2
chrX_-_15782803 2.161 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chrX_-_15782859 2.157 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr17_-_33043514 2.132 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr19_+_10626106 2.075 ILF3
interleukin enhancer binding factor 3, 90kDa
chr18_+_9126742 2.031 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr19_-_45948211 2.029 C19orf54
chromosome 19 open reading frame 54
chr17_-_39556535 2.010 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr17_-_39556483 2.003 HDAC5
histone deacetylase 5
chr1_+_11788793 1.987 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr7_+_149696901 1.969 REPIN1
replication initiator 1
chr19_+_1018293 1.968 HMHA1
histocompatibility (minor) HA-1
chr19_+_14405100 1.956 NM_002741
PKN1
protein kinase N1
chr8_+_75066117 1.955 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr17_+_77528782 1.929 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr14_-_34661156 1.816 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr7_+_101860958 1.812 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr12_+_12761085 1.785 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr17_+_22645232 1.767 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr14_-_34661190 1.765 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr6_+_32090516 1.719 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr2_+_219751145 1.714 NM_024293
FAM134A
family with sequence similarity 134, member A
chr5_-_121441910 1.701 NM_002317
LOX
lysyl oxidase
chr15_-_70455794 1.689 HEXA
hexosaminidase A (alpha polypeptide)
chr12_-_63439449 1.667 GNS
glucosamine (N-acetyl)-6-sulfatase
chr11_+_9642200 1.630 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chrY_+_13526169 1.608 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chrX_-_15782842 1.575 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr7_-_47588652 1.569 TNS3
tensin 3
chr10_+_51497716 1.556 FAM21A
family with sequence similarity 21, member A
chr7_-_29995809 1.548 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr20_-_4743768 1.526 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr6_+_160310118 1.514 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr19_+_14405216 1.513 PKN1
protein kinase N1
chr7_+_101861007 1.497 ORAI2
ORAI calcium release-activated calcium modulator 2
chr2_+_219751192 1.489 FAM134A
family with sequence similarity 134, member A
chr18_+_30810889 1.462 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chrX_-_15782792 1.446 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr19_+_1018536 1.444 HMHA1
histocompatibility (minor) HA-1
chr12_-_63439456 1.444 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr2_+_219751230 1.436 FAM134A
family with sequence similarity 134, member A
chr17_+_77529070 1.429 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr10_+_45542653 1.416 NM_001169106
NM_001169107
NM_015262
FAM21C


FAM21A
family with sequence similarity 21, member C


family with sequence similarity 21, member A
chr11_+_75203859 1.403 NM_003369
UVRAG
UV radiation resistance associated gene
chr12_+_110935618 1.402 ERP29
endoplasmic reticulum protein 29
chr1_-_210939929 1.396 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chrX_-_15782826 1.362


chr1_-_159459814 1.350 APOA2
apolipoprotein A-II
chr14_-_34660902 1.342 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr8_+_26296439 1.342 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr12_-_61615124 1.336 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr6_+_151602787 1.328 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr16_+_2510323 1.322 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr17_-_7078446 1.309 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr2_+_176761552 1.308 NM_024501
HOXD1
homeobox D1
chrY_+_13526092 1.305 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr7_-_47588160 1.263 TNS3
tensin 3
chr7_-_47588266 1.262 TNS3
tensin 3
chr6_+_151688327 1.259 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr15_+_86983038 1.253 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr10_+_69314347 1.251 NM_012238
SIRT1
sirtuin 1
chr1_-_153195188 1.251 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr1_-_239587007 1.221 RGS7
regulator of G-protein signaling 7
chr17_-_71487038 1.219 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr2_+_46779553 1.200 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr5_+_134012133 1.198 NM_021982
SEC24A
SEC24 family, member A (S. cerevisiae)
chr10_+_51497660 1.197 NM_001005751
FAM21C
FAM21A
family with sequence similarity 21, member C
family with sequence similarity 21, member A
chr11_+_75203884 1.189 UVRAG
UV radiation resistance associated gene
chr14_-_91642703 1.167 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr16_-_1817141 1.164 NM_001040427
NM_005326
HAGH

hydroxyacylglutathione hydrolase

chr19_+_54708247 1.152 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_-_239587090 1.145 NM_002924
RGS7
regulator of G-protein signaling 7
chr6_-_109810354 1.132 CD164
CD164 molecule, sialomucin
chr7_-_1562272 1.124 NM_001097620
TMEM184A
transmembrane protein 184A
chr5_-_121441805 1.123 LOX
lysyl oxidase
chrX_-_100801472 1.121 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr19_+_1018114 1.120 NM_012292
HMHA1
histocompatibility (minor) HA-1
chr17_-_7078304 1.115 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr1_+_109963982 1.106 AMPD2
adenosine monophosphate deaminase 2
chr1_-_210939727 1.100


chr1_-_152797820 1.092 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr11_+_9642226 1.091 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr5_-_121441866 1.083 LOX
lysyl oxidase
chr11_-_6597220 1.077 TPP1
tripeptidyl peptidase I
chr1_-_152797767 1.068 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_+_109963950 1.064 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chr12_+_110935644 1.064 ERP29
endoplasmic reticulum protein 29
chr19_+_54708389 1.052 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_101835183 1.045 PAH
phenylalanine hydroxylase
chr19_+_54708312 1.035 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_-_29996429 1.035 NM_001145514
SCRN1
secernin 1
chr14_-_88953059 1.028 NM_005197
FOXN3
forkhead box N3
chr1_+_148521852 1.026 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr19_-_10625449 1.017 LOC147727
hypothetical LOC147727
chr19_+_54708302 1.016 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_+_54396086 1.016 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr6_-_109810396 1.014 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr16_+_80370426 1.009 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr2_+_143603439 1.001 ARHGAP15
Rho GTPase activating protein 15
chr1_-_40335451 0.999 PPT1
palmitoyl-protein thioesterase 1
chr22_+_36928972 0.997 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_-_71487102 0.986 NM_001185039
NM_004035
NM_007292
ACOX1


acyl-CoA oxidase 1, palmitoyl


chr12_+_51686512 0.984 EIF4B
eukaryotic translation initiation factor 4B
chr14_-_73620912 0.984 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr8_+_17824631 0.982 NM_006197
PCM1
pericentriolar material 1
chr11_+_7491789 0.980 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_40335496 0.977 PPT1
palmitoyl-protein thioesterase 1
chr12_+_110935534 0.975 NM_001034025
NM_006817
ERP29

endoplasmic reticulum protein 29

chr10_+_69314714 0.974 SIRT1
sirtuin 1
chr8_-_82557956 0.972 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chrX_-_102205736 0.962 BEX1
brain expressed, X-linked 1
chr1_-_40335504 0.961 PPT1
palmitoyl-protein thioesterase 1
chr19_+_55614006 0.961 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr17_-_75808680 0.961 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr12_-_61614930 0.957 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr6_-_31938530 0.950 NEU1
sialidase 1 (lysosomal sialidase)
chr17_-_7078399 0.950 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr14_-_91642641 0.949 ATXN3
ATXN8
ataxin 3
ataxin 8
chr19_+_45546369 0.941 PLD3
phospholipase D family, member 3
chr2_-_133144094 0.940 LYPD1
LY6/PLAUR domain containing 1
chr9_+_6747636 0.923 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr11_+_59979857 0.922 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr16_-_87450734 0.920 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr14_-_67353046 0.918 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr8_+_17824790 0.918 PCM1
pericentriolar material 1
chr3_-_126414252 0.917 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chrX_-_102205752 0.914 NM_018476
BEX1
brain expressed, X-linked 1
chr4_-_23500706 0.910 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr20_+_39199542 0.910 NM_002660
NM_182811
PLCG1

phospholipase C, gamma 1

chr22_-_37598176 0.910 NM_014292
CBX6
chromobox homolog 6
chr17_+_77528699 0.909 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr19_+_1022208 0.907 HMHA1
histocompatibility (minor) HA-1
chr11_+_9642229 0.906 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr3_-_4483939 0.906 SUMF1
sulfatase modifying factor 1
chr8_+_17824781 0.904 PCM1
pericentriolar material 1
chr19_+_10625896 0.901 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr11_+_118443683 0.897 NM_021729
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr19_-_15097465 0.892 NM_006844
ILVBL
ilvB (bacterial acetolactate synthase)-like
chrX_+_128741578 0.891 SASH3
SAM and SH3 domain containing 3
chr1_-_11788666 0.891 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_30581377 0.887 NM_000167
NM_001128127
NM_203391
GK


glycerol kinase


chr12_+_51686328 0.885 NM_001417
EIF4B
eukaryotic translation initiation factor 4B
chr3_-_11585264 0.883 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr11_+_7491576 0.881 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_+_54396118 0.875 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chrX_+_128741562 0.871 NM_018990
SASH3
SAM and SH3 domain containing 3
chr7_+_149200937 0.871 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr1_-_152797760 0.869 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr13_-_31900218 0.869 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr17_+_39778016 0.867 NM_002087
GRN
granulin
chr22_+_34025872 0.864 TOM1
target of myb1 (chicken)
chr12_-_63439415 0.862 GNS
glucosamine (N-acetyl)-6-sulfatase
chr2_-_196744546 0.861 NM_004226
STK17B
serine/threonine kinase 17b
chr14_-_34661387 0.847 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr1_-_210939820 0.842 BATF3
basic leucine zipper transcription factor, ATF-like 3
chrX_+_100765006 0.841 NM_177948
ARMCX3
armadillo repeat containing, X-linked 3
chr17_-_74432671 0.834 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_+_39778180 0.834 GRN
granulin
chr19_+_45546171 0.830 NM_001031696
NM_012268
PLD3

phospholipase D family, member 3

chr3_+_49002774 0.825 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr1_-_152797707 0.822 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr16_+_80370400 0.821 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_-_108918440 0.815 GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr17_-_73636362 0.813 TMC6
transmembrane channel-like 6
chr6_+_138230045 0.812 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_+_39778153 0.808 GRN
granulin
chr11_+_118443738 0.808 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.43 1.23e-06 GO:0005773 vacuole
2.49 8.19e-06 GO:0000323 lytic vacuole
2.49 8.19e-06 GO:0005764 lysosome
1.21 1.05e-04 GO:0044444 cytoplasmic part
1.15 1.30e-04 GO:0043227 membrane-bounded organelle
3.24 1.33e-04 GO:0005765 lysosomal membrane
1.15 1.45e-04 GO:0043231 intracellular membrane-bounded organelle
2.87 1.89e-04 GO:0005774 vacuolar membrane
1.22 2.09e-04 GO:0044446 intracellular organelle part
1.10 2.41e-04 GO:0005622 intracellular
1.13 2.50e-04 GO:0043226 organelle
1.10 3.14e-04 GO:0044424 intracellular part
1.13 3.30e-04 GO:0043229 intracellular organelle
1.21 3.93e-04 GO:0044422 organelle part
2.75 4.38e-04 GO:0044437 vacuolar part
1.32 7.06e-03 GO:0031974 membrane-enclosed lumen
1.13 9.19e-03 GO:0005737 cytoplasm
1.43 1.03e-02 GO:0005654 nucleoplasm
1.31 1.51e-02 GO:0043233 organelle lumen
3.43 2.37e-02 GO:0005798 Golgi-associated vesicle
1.29 4.98e-02 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 4.29e-03 GO:0005515 protein binding