Motif ID: STAT2,4,6.p2

Z-value: 2.543


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT4chr2_-_191723951,
chr2_-_191724169
-0.467.2e-02Click!
STAT2chr12_-_550401830.282.9e-01Click!
STAT6chr12_-_557914430.029.4e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_9159789 5.389 NM_000014
A2M
alpha-2-macroglobulin
chr14_+_94148466 5.102 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_-_188945921 4.005 BCL6
B-cell CLL/lymphoma 6
chr3_-_188946168 3.841 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr8_-_27524744 3.385 NM_203339
CLU
clusterin
chr8_-_27525084 3.304 NM_001171138
CLU
clusterin
chr12_-_9159780 3.070 A2M
alpha-2-macroglobulin
chr3_+_187813553 2.884 AHSG
alpha-2-HS-glycoprotein
chr5_+_71538456 2.792 MAP1B
microtubule-associated protein 1B
chr3_+_187813405 2.723 AHSG
alpha-2-HS-glycoprotein
chr3_+_187813538 2.705 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr17_+_1592879 2.660 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr1_-_228916486 2.326 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_228916958 2.303 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_-_7136189 2.246 C1R
complement component 1, r subcomponent
chr12_-_7136147 2.242 NM_001733
C1R
complement component 1, r subcomponent
chr1_-_228916470 2.228 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_-_9159742 2.163 A2M
alpha-2-macroglobulin
chr8_-_27528105 2.149 CLU
clusterin
chr17_+_1593040 2.137 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr1_-_20682541 2.126


chrX_-_132947290 2.052 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chrX_-_132947141 2.043 GPC3
glypican 3
chr4_-_155731288 2.000 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr19_+_40465249 1.846 NM_021175
HAMP
hepcidin antimicrobial peptide
chr11_+_57122153 1.787 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr5_-_121441910 1.746 NM_002317
LOX
lysyl oxidase
chr11_+_57121602 1.744 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr4_-_155753332 1.741 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr4_-_155753207 1.721 FGG
fibrinogen gamma chain
chr4_-_155753272 1.709 FGG
fibrinogen gamma chain
chr4_-_155753249 1.706 FGG
fibrinogen gamma chain
chr4_+_89115923 1.699 SPP1
secreted phosphoprotein 1
chr10_-_52315390 1.695 A1CF
APOBEC1 complementation factor
chr3_+_134978615 1.691 TF
transferrin
chr4_-_155753287 1.687 FGG
fibrinogen gamma chain
chrX_+_105932536 1.675 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr4_+_89115892 1.663 SPP1
secreted phosphoprotein 1
chr12_+_7038240 1.657 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr5_-_111120817 1.650 NM_004772
C5orf13
chromosome 5 open reading frame 13
chrX_+_115481774 1.598 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr4_+_89115862 1.582 SPP1
secreted phosphoprotein 1
chr4_+_89115825 1.542 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr8_-_27528215 1.533 NM_001831
CLU
clusterin
chr8_-_48813236 1.510 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_17779528 1.502 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr8_-_48813256 1.452 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr22_+_19458378 1.444 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr7_+_134114957 1.439 CALD1
caldesmon 1
chr3_+_52803823 1.438 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr3_+_189354167 1.398 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_90740935 1.374 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_111120764 1.351 C5orf13
chromosome 5 open reading frame 13
chr11_+_10283171 1.348 NM_001124
ADM
adrenomedullin
chr11_-_27637771 1.339 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr14_-_52487022 1.337 FERMT2
fermitin family member 2
chr10_-_52315436 1.324 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_-_150422474 1.313 NM_000096
CP
ceruloplasmin (ferroxidase)
chr17_-_7023283 1.308 ASGR1
asialoglycoprotein receptor 1
chr12_+_51730101 1.295 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_43919392 1.281 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr17_-_7023378 1.280 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr4_+_74497998 1.255 ALB
albumin
chr6_+_32021793 1.253 CFB
complement factor B
chr19_+_49248003 1.230 NM_013361
ZNF223
zinc finger protein 223
chr8_+_26427378 1.228 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr17_+_4621924 1.227 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr19_-_49552638 1.220 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chrX_+_133952633 1.218 NM_001163438
LOC644538
hypothetical protein LOC644538
chr1_+_205329206 1.217 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr14_+_20608179 1.205 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr6_+_32021831 1.205 CFB
complement factor B
chr6_+_32021742 1.201 CFB
complement factor B
chr9_+_102830851 1.194 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr7_-_149669622 1.186 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr1_+_205328834 1.170 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr6_+_30238961 1.144 NM_033229
TRIM15
tripartite motif containing 15
chr3_+_134947573 1.132 NM_001063
TF
transferrin
chrX_-_106130098 1.130 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr14_+_23175383 1.124 NM_005794
NM_182908
DHRS2

dehydrogenase/reductase (SDR family) member 2

chr1_+_200246370 1.123 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr16_+_70646008 1.113 NM_001126102
NM_005143
HP

haptoglobin

chr14_-_93829347 1.106 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_+_50109903 1.103 APOC1
apolipoprotein C-I
chr17_-_74487527 1.092 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr3_+_173240126 1.082 FNDC3B
fibronectin type III domain containing 3B
chr3_-_125085834 1.078 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr2_+_17585287 1.073 NM_003385
VSNL1
visinin-like 1
chr17_-_23721430 1.072 VTN
vitronectin
chr6_+_32021687 1.072 NM_001710
CFB
complement factor B
chr2_-_166940710 1.063 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr22_+_36928011 1.052 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_+_14141583 1.052 TMEM43
transmembrane protein 43
chr6_+_32003380 1.050 C2
complement component 2
chr19_+_15079141 1.045 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr5_-_121441805 1.045 LOX
lysyl oxidase
chr1_+_153366559 1.038 EFNA1
ephrin-A1
chr14_-_53493198 1.037 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr19_+_58715988 1.035 NM_018555
ZNF331
zinc finger protein 331
chr17_-_23721420 1.030 VTN
vitronectin
chr17_-_23721468 1.025 VTN
vitronectin
chr3_+_14141440 1.022 NM_024334
TMEM43
transmembrane protein 43
chr2_-_218516950 1.020 NM_022648
TNS1
tensin 1
chr1_+_200246312 1.020 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr5_-_111119846 1.019 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr5_-_121441866 1.018 LOX
lysyl oxidase
chr3_+_14141544 1.017 TMEM43
transmembrane protein 43
chr17_-_77884899 1.010 SECTM1
secreted and transmembrane 1
chr2_-_160972606 1.009 RBMS1
RNA binding motif, single stranded interacting protein 1
chr4_+_74498042 1.009 ALB
albumin
chr16_-_28457825 1.008 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr18_+_27425727 1.001 NM_000371
TTR
transthyretin
chr17_-_77884926 0.996 SECTM1
secreted and transmembrane 1
chr17_-_38979178 0.993 NM_001079675
ETV4
ets variant 4
chr9_-_116920232 0.986 NM_002160
TNC
tenascin C
chr14_-_64479198 0.984 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_167342493 0.982 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr5_-_111340421 0.981 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr8_-_120720200 0.978 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr17_-_23721351 0.977 VTN
vitronectin
chr10_+_114699953 0.976 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr14_-_68515731 0.973 ACTN1
actinin, alpha 1
chr16_-_28457728 0.964 NUPR1
nuclear protein, transcriptional regulator, 1
chr11_+_73034870 0.959 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_+_14141633 0.956 TMEM43
transmembrane protein 43
chr16_+_68284252 0.955 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_+_235525355 0.944 NM_014521
SH3BP4
SH3-domain binding protein 4
chr14_-_68515761 0.935 ACTN1
actinin, alpha 1
chr14_+_74815233 0.934 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chrX_+_102518764 0.931 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr17_-_77885192 0.931 NM_003004
SECTM1
secreted and transmembrane 1
chr20_+_43470354 0.930 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_-_68515727 0.927 ACTN1
actinin, alpha 1
chr6_+_151602787 0.922 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr22_+_36927884 0.919 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr16_+_31390567 0.909 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr15_+_68971835 0.907 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr17_+_29606408 0.907 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr14_-_68515791 0.905 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr17_+_72827185 0.905 NM_006640
SEPT9
septin 9
chr14_-_68515742 0.903 ACTN1
actinin, alpha 1
chr12_+_132167057 0.899 NM_003440
ZNF140
zinc finger protein 140
chr4_+_54790020 0.897 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_-_111121150 0.895 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr5_-_55326358 0.886 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr19_-_48815572 0.882 ZNF428
zinc finger protein 428
chr17_+_72827227 0.879 SEPT9
septin 9
chr16_+_29378694 0.869 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr5_-_111120929 0.867 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr14_-_24588916 0.865 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr3_-_159932965 0.855 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr17_+_45979518 0.848 NM_022827
SPATA20
spermatogenesis associated 20
chr14_-_68515701 0.841 ACTN1
actinin, alpha 1
chr16_+_67778441 0.837 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr6_-_35572694 0.835 NM_003214
TEAD3
TEA domain family member 3
chr15_+_30797466 0.814 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr7_-_22363036 0.812 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr15_-_99847514 0.808 PCSK6
proprotein convertase subtilisin/kexin type 6
chr4_+_4912272 0.805 NM_002448
MSX1
msh homeobox 1
chr3_+_180853473 0.791 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr3_-_159932924 0.783 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr6_-_31938530 0.780 NEU1
sialidase 1 (lysosomal sialidase)
chr1_+_203740391 0.778 CDK18
cyclin-dependent kinase 18
chr11_+_7463175 0.775 NM_198474
OLFML1
olfactomedin-like 1
chr6_-_111243100 0.772 NM_015076
CDK19
cyclin-dependent kinase 19
chrX_+_54852217 0.768 NM_201222
MAGED2
melanoma antigen family D, 2
chr19_+_10242516 0.766 NM_000201
ICAM1
intercellular adhesion molecule 1
chr16_+_52295545 0.765 FTO
fat mass and obesity associated
chr19_+_40224457 0.762 HPN
hepsin
chr19_-_48815853 0.762 NM_182498
ZNF428
zinc finger protein 428
chr10_-_101831579 0.760 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr22_+_34374358 0.759 NM_030641
APOL6
apolipoprotein L, 6
chr10_+_71482362 0.753 NM_018649
H2AFY2
H2A histone family, member Y2
chr1_+_32418234 0.750 TXLNA
taxilin alpha
chr3_+_45042754 0.746 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr11_+_19691397 0.743 NM_145117
NM_182964
NAV2

neuron navigator 2

chr19_+_3045266 0.740 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr1_+_63861474 0.737 NM_001172818
PGM1
phosphoglucomutase 1
chr6_+_32003180 0.730 NM_000063
NM_001145903
C2

complement component 2

chr12_-_7153068 0.730 NM_016546
C1RL
complement component 1, r subcomponent-like
chrX_-_99778340 0.726 NM_003270
TSPAN6
tetraspanin 6
chr4_-_89963177 0.720 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr2_+_228386800 0.720 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr2_+_201158975 0.717 NM_001159
AOX1
aldehyde oxidase 1
chr20_+_43470042 0.716 NM_001048225
NM_001048226
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr8_-_13178399 0.714 DLC1
deleted in liver cancer 1
chr16_+_52295375 0.712 NM_001080432
FTO
fat mass and obesity associated
chr4_+_155703581 0.709 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr3_-_52454082 0.709 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr4_-_186934059 0.708 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr20_+_43425153 0.708 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 read-through transcript
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr3_-_159932899 0.707 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr1_-_56750235 0.698 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_176449156 0.698 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr13_-_47885653 0.697 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr10_+_17891348 0.696 NM_001009567
NM_002438
MRC1L1
MRC1
mannose receptor, C type 1-like 1
mannose receptor, C type 1
chr9_-_106730256 0.685 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr17_+_2646481 0.676 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr20_+_33667160 0.674 NM_003116
SPAG4
sperm associated antigen 4
chr19_+_53559468 0.669 NM_012451
SYNGR4
synaptogyrin 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.63 1.07e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.19 4.99e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 4.59e-02 GO:0043169 cation binding