Motif ID: ZEB1.p2

Z-value: 3.644


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31647425-0.844.9e-05Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_43446937 8.570 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_43447078 8.522 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43447262 7.658 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr7_+_26298018 7.242 NM_013322
SNX10
sorting nexin 10
chr4_+_75529716 6.213 NM_001657
AREG
amphiregulin
chr2_+_47449790 5.938 NM_002354
EPCAM
epithelial cell adhesion molecule
chr7_+_26298136 5.505 SNX10
sorting nexin 10
chr2_+_47449951 5.136 EPCAM
epithelial cell adhesion molecule
chr6_+_7486836 5.096 DSP
desmoplakin
chr6_+_7486862 5.007 NM_001008844
NM_004415
DSP

desmoplakin

chr6_+_7486891 4.896 DSP
desmoplakin
chr4_+_75699652 4.788 NM_001657
AREG
amphiregulin
chr20_-_6051562 4.672 FERMT1
fermitin family member 1
chr19_+_40431359 4.405 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr18_+_27332024 4.387 NM_001943
DSG2
desmoglein 2
chr16_+_67328693 4.309 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr2_-_166359016 4.161 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr19_+_40431618 3.859 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_95722448 3.597 ESRP1
epithelial splicing regulatory protein 1
chrX_+_152562013 3.562 DUSP9
dual specificity phosphatase 9
chr21_-_42060266 3.444 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr17_-_37196463 3.400 NM_002230
NM_021991
JUP

junction plakoglobin

chr16_+_67236730 3.365 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr19_+_40431122 3.335 LSR
lipolysis stimulated lipoprotein receptor
chr21_-_42060334 3.298 RIPK4
receptor-interacting serine-threonine kinase 4
chr14_-_66948523 3.283 NM_016445
PLEK2
pleckstrin 2
chr14_-_66948612 3.246 PLEK2
pleckstrin 2
chr2_+_17585287 3.110 NM_003385
VSNL1
visinin-like 1
chr1_+_1971762 3.104 NM_002744
PRKCZ
protein kinase C, zeta
chr2_+_17585462 3.000 VSNL1
visinin-like 1
chrX_+_130985316 2.963 NM_001042452
MST4
serine/threonine protein kinase MST4
chr19_+_40431678 2.946 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_67328715 2.935 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr11_+_32808045 2.733 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr8_+_86563382 2.711 NM_000067
CA2
carbonic anhydrase II
chr5_+_76150588 2.478 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr20_+_60918836 2.455 NM_001853
COL9A3
collagen, type IX, alpha 3
chr6_-_10527772 2.366 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr16_-_66827449 2.338 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr5_+_167651063 2.296 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr17_+_71033339 2.279 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr20_-_10602139 2.230 JAG1
jagged 1
chr14_-_60817709 2.230 TMEM30B
transmembrane protein 30B
chr11_+_696103 2.221 NM_022772
EPS8L2
EPS8-like 2
chr11_-_70837019 2.215 DHCR7
7-dehydrocholesterol reductase
chr3_-_45162865 2.192 CDCP1
CUB domain containing protein 1
chr7_-_22363036 2.184 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_71229110 2.184 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr4_-_35922288 2.151 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_124124196 2.150 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_-_51200347 2.139 NM_000424
KRT5
keratin 5
chr11_+_712282 2.122 EPS8L2
EPS8-like 2
chr1_-_58815415 2.087 TACSTD2
tumor-associated calcium signal transducer 2
chr1_+_60053050 2.059 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr3_-_45162847 2.021 CDCP1
CUB domain containing protein 1
chr2_-_20288647 2.019 NM_001006946
SDC1
syndecan 1
chr17_+_71229151 2.006 ITGB4
integrin, beta 4
chr3_-_45162901 2.001 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr2_-_20288108 1.992 NM_002997
SDC1
syndecan 1
chr16_-_11588257 1.950 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr2_-_216586488 1.949 NM_018000
MREG
melanoregulin
chr16_-_11588525 1.940 LITAF
lipopolysaccharide-induced TNF factor
chr5_+_76150637 1.919 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr18_+_59295123 1.887 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr20_-_10602429 1.827 NM_000214
JAG1
jagged 1
chr14_-_60818263 1.788 NM_001017970
TMEM30B
transmembrane protein 30B
chr14_+_100270222 1.764 DLK1
delta-like 1 homolog (Drosophila)
chr17_+_71229191 1.758 ITGB4
integrin, beta 4
chr3_+_187813538 1.725 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr6_+_36206239 1.712 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr1_+_181422016 1.697 LAMC2
laminin, gamma 2
chr19_-_56178882 1.685 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr14_+_30413393 1.680 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr20_+_43468046 1.646 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr2_+_162908828 1.637 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr17_-_77634455 1.626 FASN
fatty acid synthase
chr3_+_187813553 1.589 AHSG
alpha-2-HS-glycoprotein
chr17_-_77635703 1.581 FASN
fatty acid synthase
chr20_+_25176698 1.572 NM_002862
PYGB
phosphorylase, glycogen; brain
chr3_+_187813405 1.532 AHSG
alpha-2-HS-glycoprotein
chr6_-_47385313 1.488 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_+_124124083 1.484 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_-_56214765 1.482 NM_145888
KLK10
kallikrein-related peptidase 10
chr6_-_47385205 1.463 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr7_+_115637795 1.449 NM_015641
TES
testis derived transcript (3 LIM domains)
chr12_+_54760211 1.440 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr6_-_47385605 1.422 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_+_54760153 1.415 NM_001005915
NM_001982
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr6_-_47385470 1.385 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chrX_+_152608159 1.383 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr3_-_191321367 1.365 LEPREL1
leprecan-like 1
chr2_-_165186232 1.359 GRB14
growth factor receptor-bound protein 14
chr20_+_43468617 1.350 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr4_+_4439705 1.348 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr1_+_152644292 1.339 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr12_+_56271181 1.326 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr2_-_165186064 1.318 GRB14
growth factor receptor-bound protein 14
chr17_-_36938025 1.292 KRT19
keratin 19
chr12_+_56271259 1.279 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr19_+_7608010 1.273 STXBP2
syntaxin binding protein 2
chr1_-_159257567 1.269 F11R
F11 receptor
chr11_+_120828058 1.266 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr11_-_114880275 1.265 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr8_+_95722516 1.261 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr8_+_95722575 1.259 ESRP1
epithelial splicing regulatory protein 1
chr18_-_19420438 1.253 NM_000271
NPC1
Niemann-Pick disease, type C1
chr4_+_79691765 1.241 NM_005139
ANXA3
annexin A3
chr11_-_70837090 1.240 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr16_+_67236699 1.238 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr20_+_60744231 1.218 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr18_-_19420376 1.217 NPC1
Niemann-Pick disease, type C1
chr4_+_128922852 1.215 NM_014278
HSPA4L
heat shock 70kDa protein 4-like
chr19_+_7608015 1.211 STXBP2
syntaxin binding protein 2
chr19_+_40299058 1.210 FXYD3
FXYD domain containing ion transport regulator 3
chr4_+_85723080 1.209 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr17_+_2627099 1.208 RAP1GAP2
RAP1 GTPase activating protein 2
chr4_-_152155827 1.204 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr20_+_43425153 1.200 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 read-through transcript
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr3_+_143797895 1.195 NM_001145319
PLS1
plastin 1
chr2_+_162908869 1.192 GCA
grancalcin, EF-hand calcium binding protein
chr2_+_215885063 1.189 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr8_-_145609737 1.186 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr1_-_159257486 1.182 F11R
F11 receptor
chr1_+_181421796 1.176 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr4_-_56996400 1.175 NM_002703
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr12_-_109424260 1.169 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr17_+_38064787 1.168 NM_016437
TUBG2
tubulin, gamma 2
chr12_-_28014151 1.166 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr19_+_7607976 1.153 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr11_+_67836575 1.150 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr5_-_1577022 1.143 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr3_-_8668723 1.140 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr2_-_121759237 1.139 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr1_+_109594163 1.136 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr17_+_52517529 1.132 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1
chr8_-_110726201 1.127 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr1_+_181421984 1.115 LAMC2
laminin, gamma 2
chr16_-_4927057 1.105 NM_002705
PPL
periplakin
chr16_+_1668284 1.087 HN1L
hematological and neurological expressed 1-like
chr1_-_27113018 1.084 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr17_+_77529070 1.077 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr16_+_1668257 1.066 NM_144570
HN1L
hematological and neurological expressed 1-like
chr17_+_77528782 1.066 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr7_+_16759845 1.052 NM_014399
TSPAN13
tetraspanin 13
chr1_+_161027115 1.048 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr4_+_4439618 1.040 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr6_+_30402203 1.034


chr17_-_77649322 1.024 FASN
fatty acid synthase
chr7_-_51351952 1.004 NM_015198
COBL
cordon-bleu homolog (mouse)
chrX_-_152804731 1.001 L1CAM
L1 cell adhesion molecule
chr20_-_6052056 0.995 NM_017671
FERMT1
fermitin family member 1
chr9_-_99994704 0.995 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr17_+_77528699 0.990 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr1_+_46418786 0.982 TSPAN1
tetraspanin 1
chr14_+_64240902 0.978 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr18_+_53967544 0.978 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr4_+_89519134 0.977 HERC6
hect domain and RLD 6
chr13_+_27092846 0.972 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr1_-_218168137 0.968 SLC30A10
solute carrier family 30, member 10
chr12_-_61614930 0.964 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_+_43971689 0.963 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr2_+_64534774 0.960 NM_014181
HSPC159
galectin-related protein
chr11_+_69602055 0.957 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr15_+_48261649 0.954 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr19_-_51909416 0.951 NM_001079882
PRKD2
protein kinase D2
chr4_+_128922930 0.948 HSPA4L
heat shock 70kDa protein 4-like
chr1_+_26744893 0.945 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_+_89519004 0.939 HERC6
hect domain and RLD 6
chr16_-_51139214 0.927 NM_001146188
TOX3
TOX high mobility group box family member 3
chr8_-_81246215 0.924 NM_001025253
NM_005079
TPD52

tumor protein D52

chr18_+_11679135 0.924 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr17_-_2561676 0.922 NM_015229
KIAA0664
KIAA0664
chr3_-_31998241 0.913 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr2_+_118562499 0.912 NM_016133
INSIG2
insulin induced gene 2
chr1_+_26744929 0.912 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_+_4439750 0.907 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr1_-_159275357 0.907 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr20_+_309272 0.906 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr5_-_74198370 0.904 NM_015566
FAM169A
family with sequence similarity 169, member A
chr12_-_51173238 0.897 NM_005554
KRT6A
keratin 6A
chr4_+_89518898 0.893 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr1_-_58815753 0.886 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr19_+_7608020 0.885 STXBP2
syntaxin binding protein 2
chr10_+_38685299 0.873 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr1_+_39229474 0.870 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr7_+_94374862 0.867 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr17_+_62804385 0.866 NM_012417
NM_181671
PITPNC1

phosphatidylinositol transfer protein, cytoplasmic 1

chr16_-_51138306 0.866 NM_001080430
TOX3
TOX high mobility group box family member 3
chr1_-_159275334 0.857 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr5_+_271355 0.846 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr14_-_20636337 0.841 ZNF219
zinc finger protein 219
chr10_-_118754717 0.840 KIAA1598
KIAA1598
chr3_+_168936125 0.840 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr12_-_116021473 0.839 NM_001168325
NM_017899
TESC

tescalcin

chr19_+_8415875 0.831 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr4_-_15694764 0.822 PROM1
prominin 1
chr3_-_191321601 0.818 NM_018192
LEPREL1
leprecan-like 1
chr3_-_56810869 0.814 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr9_-_5822840 0.812 ERMP1
endoplasmic reticulum metallopeptidase 1
chr16_-_66252103 0.806 NM_001082486
NM_001082487
NM_022914
ACD


adrenocortical dysplasia homolog (mouse)



Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.34 4.37e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.34 2.10e-02 GO:0016301 kinase activity
1.35 3.22e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.23 3.54e-02 GO:0032559 adenyl ribonucleotide binding
1.23 3.84e-02 GO:0030554 adenyl nucleotide binding