Motif ID: ZIC1..3.p2

Z-value: 1.021


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486098410.514.4e-02Click!
ZIC3chrX_+_136475979-0.431.0e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_52812165 1.634 FST
follistatin
chr15_+_37660568 1.590 NM_003246
THBS1
thrombospondin 1
chr16_+_69060325 1.249 FUK
fucokinase
chr5_-_121440704 1.193 NM_001178102
LOX
lysyl oxidase
chr11_-_11987115 1.189 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_-_111287657 1.184 NM_001885
CRYAB
crystallin, alpha B
chr5_+_52812236 1.174 NM_006350
NM_013409
FST

follistatin

chr10_-_90702490 1.118 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr11_-_65396775 1.091 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr21_+_41461962 1.078 BACE2
beta-site APP-cleaving enzyme 2
chr11_-_11986704 0.993 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_+_19691397 0.985 NM_145117
NM_182964
NAV2

neuron navigator 2

chr16_+_31390567 0.975 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr15_+_61127367 0.974 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr11_-_11987198 0.974 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_+_75343352 0.955 PLAU
plasminogen activator, urokinase
chr3_-_73756668 0.948 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr11_+_111288669 0.938 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr11_-_2108035 0.917 IGF2
insulin-like growth factor 2 (somatomedin A)
chrX_-_128485134 0.884 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr11_+_111288686 0.875 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr7_+_129919157 0.869 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr7_+_129918408 0.843 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr19_-_54835162 0.839 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chrX_-_128485121 0.818 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chrX_-_128485062 0.798 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr9_-_112840064 0.789 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr11_+_19328846 0.785 NM_001111018
NAV2
neuron navigator 2
chr3_-_124893875 0.781 MYLK
myosin light chain kinase
chr4_-_102486975 0.762 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr9_+_123101701 0.750 NM_000177
GSN
gelsolin
chr3_-_55490401 0.748 WNT5A
wingless-type MMTV integration site family, member 5A
chr10_-_95350949 0.732 NM_006744
RBP4
retinol binding protein 4, plasma
chr2_+_235525355 0.720 NM_014521
SH3BP4
SH3-domain binding protein 4
chr4_-_102487356 0.710 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr10_-_62373828 0.706 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr9_+_123101926 0.682 GSN
gelsolin
chr12_+_6179736 0.674 NM_001769
CD9
CD9 molecule
chr21_-_27139143 0.669 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr16_+_54070302 0.666 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr11_+_44074322 0.630 NM_000401
EXT2
exostosin 2
chr6_-_128883125 0.627 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr21_-_27139563 0.627 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chrX_+_51653348 0.621 NM_001005333
NM_006986
MAGED1

melanoma antigen family D, 1

chrX_+_133993984 0.620 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr9_+_111850698 0.615 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr15_-_27901828 0.615 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr22_+_36531178 0.606 H1F0
H1 histone family, member 0
chr1_-_85703321 0.604 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_-_151171576 0.602 PFN2
profilin 2
chr22_+_36531246 0.602 H1F0
H1 histone family, member 0
chr21_-_26465005 0.593 NM_000484
NM_001136129
NM_001136130
NM_201413
NM_201414
APP




amyloid beta (A4) precursor protein




chr16_+_55230078 0.586 NM_005946
MT1A
metallothionein 1A
chr14_-_50480857 0.570 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chrX_+_51944658 0.568 NM_001098800
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B


melanoma antigen family D, 4
melanoma antigen family D, 4B


chr12_-_105165805 0.565 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr2_+_217206327 0.564 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_+_217206450 0.554 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_-_175578156 0.547 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr12_+_51777684 0.544 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr1_+_201862552 0.534 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr11_-_2115086 0.530 IGF2
insulin-like growth factor 2 (somatomedin A)
chr21_+_41461924 0.525 BACE2
beta-site APP-cleaving enzyme 2
chr1_+_181258952 0.522 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr12_+_51777715 0.519 IGFBP6
insulin-like growth factor binding protein 6
chr6_+_142664490 0.508 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr4_+_166519392 0.507 NM_001873
CPE
carboxypeptidase E
chr10_+_124124196 0.506 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_-_151171190 0.503 NM_002628
NM_053024
PFN2

profilin 2

chr15_+_22772545 0.499 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr17_+_58058783 0.499 MRC2
mannose receptor, C type 2
chrX_-_48818585 0.485 NM_007213
PRAF2
PRA1 domain family, member 2
chr5_+_71438796 0.480 NM_005909
MAP1B
microtubule-associated protein 1B
chr6_+_151603346 0.468 AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_168204430 0.467


chr2_+_219991342 0.466 NM_001927
DES
desmin
chr8_+_22492586 0.466 PDLIM2
PDZ and LIM domain 2 (mystique)
chr11_+_131285747 0.459 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr20_-_17610828 0.457 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr7_-_149669622 0.456 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr16_+_30952382 0.452 NM_004604
STX4
syntaxin 4
chr1_-_151804929 0.444 NM_005978
S100A2
S100 calcium binding protein A2
chr8_-_67687980 0.440 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

hypothetical LOC645895
chr20_-_61728774 0.439 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr7_-_150576660 0.438 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr20_+_337346 0.433 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr3_-_31997738 0.431 OSBPL10
oxysterol binding protein-like 10
chr14_+_64076916 0.431 NM_021979
HSPA2
heat shock 70kDa protein 2
chr21_-_26464915 0.425 APP
amyloid beta (A4) precursor protein
chrX_-_13866451 0.425 GPM6B
glycoprotein M6B
chr8_-_13035102 0.422 NM_006094
DLC1
deleted in liver cancer 1
chr7_+_116099648 0.419 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr2_-_26058941 0.409 NM_002254
KIF3C
kinesin family member 3C
chrX_+_54852217 0.409 NM_201222
MAGED2
melanoma antigen family D, 2
chr14_+_64077171 0.408 HSPA2
heat shock 70kDa protein 2
chr16_+_30952350 0.408 STX4
syntaxin 4
chr2_-_26058831 0.407 KIF3C
kinesin family member 3C
chr7_-_150576957 0.405 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr6_+_151603201 0.403 AKAP12
A kinase (PRKA) anchor protein 12
chr2_+_8739563 0.403 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_+_181259317 0.401


chr1_+_201862548 0.401 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chrX_-_119487096 0.395 LAMP2
lysosomal-associated membrane protein 2
chr1_-_85703198 0.392 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr16_+_30951915 0.392 STX4
syntaxin 4
chr20_+_25176698 0.382 NM_002862
PYGB
phosphorylase, glycogen; brain
chr9_-_35679799 0.380 TPM2
tropomyosin 2 (beta)
chr11_-_27697768 0.379 NM_001143807
BDNF
brain-derived neurotrophic factor
chr2_+_202607554 0.379 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr20_+_61798446 0.378 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr6_+_148705817 0.375 SASH1
SAM and SH3 domain containing 1
chr9_-_112840801 0.374 LPAR1
lysophosphatidic acid receptor 1
chr14_-_104515738 0.374 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr4_+_74493218 0.373 ALB
albumin
chr8_+_31616809 0.372 NM_013962
NRG1
neuregulin 1
chrX_-_37591760 0.371 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr13_-_109236897 0.371 NM_003749
IRS2
insulin receptor substrate 2
chr1_-_27802947 0.371 AHDC1
AT hook, DNA binding motif, containing 1
chrX_-_119487164 0.369 LAMP2
lysosomal-associated membrane protein 2
chr17_-_6958695 0.367 ASGR2
asialoglycoprotein receptor 2
chr9_-_73573121 0.365 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr6_-_35572694 0.364 NM_003214
TEAD3
TEA domain family member 3
chr7_+_79602023 0.362 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr4_-_54625463 0.361 CHIC2
cysteine-rich hydrophobic domain 2
chr20_+_48240705 0.361 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chrX_-_13866565 0.361 NM_001001994
GPM6B
glycoprotein M6B
chr9_-_35679902 0.359 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr5_+_131621287 0.356 PDLIM4
PDZ and LIM domain 4
chr4_+_74493331 0.356 ALB
albumin
chrX_-_37591703 0.352 DYNLT3
dynein, light chain, Tctex-type 3
chr10_+_170423 0.346 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr18_+_54013575 0.344 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr20_-_36191623 0.338 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr6_+_148705646 0.337 SASH1
SAM and SH3 domain containing 1
chr4_-_102487649 0.336 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr18_+_7557313 0.336 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr2_-_220144427 0.334 OBSL1
obscurin-like 1
chr4_+_74493266 0.332 ALB
albumin
chr9_-_122516399 0.332 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr20_+_48240772 0.332 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr9_-_87904844 0.331 NM_177937
GOLM1
golgi membrane protein 1
chr16_-_66827449 0.331 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chrX_+_17665483 0.323 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr11_-_70350292 0.321 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr19_+_8384181 0.321 NM_001005415
NM_001005416
NM_016496
MARCH2


membrane-associated ring finger (C3HC4) 2


chr19_-_12747421 0.319 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr5_+_86599350 0.318 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr16_-_65343012 0.318 NM_006141
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr3_-_95175588 0.317 NM_000313
PROS1
protein S (alpha)
chr1_-_93919789 0.316 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr10_+_124124083 0.315 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_62787534 0.315 NM_001142614
EHBP1
EH domain binding protein 1
chr6_+_1335067 0.315 NM_001452
FOXF2
forkhead box F2
chr11_-_61415429 0.314 NM_021727
FADS3
fatty acid desaturase 3
chr12_+_12935222 0.313 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chrX_-_108863109 0.313 ACSL4
acyl-CoA synthetase long-chain family member 4
chr5_-_141684759 0.313 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr11_-_35503720 0.311 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr7_+_94130673 0.310 PEG10
paternally expressed 10
chr20_+_43874735 0.307 UBE2C
ubiquitin-conjugating enzyme E2C
chr2_+_20510312 0.306 NM_004040
RHOB
ras homolog gene family, member B
chr3_-_187025501 0.303 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr4_-_54625223 0.303 CHIC2
cysteine-rich hydrophobic domain 2
chr1_+_43837096 0.302 PTPRF
protein tyrosine phosphatase, receptor type, F
chr8_-_145097031 0.301 NM_201380
PLEC
plectin
chr12_+_77782719 0.300 SYT1
synaptotagmin I
chr12_+_12935619 0.298 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr22_-_49063088 0.297 PLXNB2
plexin B2
chrX_+_101792949 0.296 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr17_-_15109315 0.295 NM_000304
PMP22
peripheral myelin protein 22
chr19_+_627346 0.293 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr5_+_131621276 0.291 PDLIM4
PDZ and LIM domain 4
chr19_-_12747263 0.288 HOOK2
hook homolog 2 (Drosophila)
chr7_+_134114957 0.287 CALD1
caldesmon 1
chr12_+_109536214 0.284 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chrX_+_70359780 0.284 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr9_-_130912728 0.282 NM_000755
CRAT
carnitine O-acetyltransferase
chr14_+_105012106 0.282 NM_001312
CRIP2
cysteine-rich protein 2
chr4_+_74493174 0.280 ALB
albumin
chr11_+_113815317 0.280 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr2_-_20075889 0.280 MATN3
matrilin 3
chr12_-_6668880 0.280 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr2_-_20288647 0.279 NM_001006946
SDC1
syndecan 1
chr18_+_19706979 0.278 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr12_+_2870255 0.277 NM_001160408
NM_003324
TULP3

tubby like protein 3

chr17_-_5344898 0.276 NM_001162371
LOC728392
hypothetical protein LOC728392
chr19_-_56147971 0.275 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chrX_+_102518764 0.275 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr8_+_9450849 0.274 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr20_-_22512893 0.272 FOXA2
forkhead box A2
chr12_+_77782648 0.269 SYT1
synaptotagmin I
chr17_-_1342700 0.269 NM_001080779
MYO1C
myosin IC
chr12_-_48902692 0.267 NM_001113547
LIMA1
LIM domain and actin binding 1
chr14_+_100362236 0.266 MEG3
maternally expressed 3 (non-protein coding)
chr20_-_17610704 0.266 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr5_+_131621230 0.266 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr20_+_43874654 0.265 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr19_-_10166536 0.265 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr20_+_43875078 0.263 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr21_-_26464931 0.262 APP
amyloid beta (A4) precursor protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 1.57e-06 GO:0048856 anatomical structure development
1.28 2.02e-06 GO:0032502 developmental process
1.49 4.34e-06 GO:0009653 anatomical structure morphogenesis
1.40 1.07e-05 GO:0048869 cellular developmental process
1.40 1.18e-05 GO:0030154 cell differentiation
1.32 1.28e-05 GO:0048731 system development
1.27 1.03e-04 GO:0007275 multicellular organismal development
1.20 3.04e-04 GO:0032501 multicellular organismal process
2.35 3.86e-03 GO:0034330 cell junction organization
1.71 7.13e-03 GO:0061024 membrane organization
1.54 7.83e-03 GO:0016192 vesicle-mediated transport
1.48 9.92e-03 GO:0048468 cell development
2.35 1.12e-02 GO:0034329 cell junction assembly
1.69 1.26e-02 GO:0016044 cellular membrane organization
1.86 2.82e-02 GO:0061061 muscle structure development
2.23 4.73e-02 GO:0042692 muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.81 2.28e-06 GO:0030054 cell junction
1.25 7.55e-06 GO:0071944 cell periphery
1.26 8.97e-06 GO:0005886 plasma membrane
1.62 4.99e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.16 5.68e-05 GO:0016020 membrane
1.60 6.47e-05 GO:0031410 cytoplasmic vesicle
2.35 7.00e-05 GO:0070161 anchoring junction
2.42 8.97e-05 GO:0005912 adherens junction
1.59 1.58e-04 GO:0031988 membrane-bounded vesicle
1.54 4.74e-04 GO:0031982 vesicle
2.50 3.12e-03 GO:0005925 focal adhesion
2.06 4.33e-03 GO:0005911 cell-cell junction
1.27 4.68e-03 GO:0044459 plasma membrane part
2.39 7.37e-03 GO:0005924 cell-substrate adherens junction
1.89 8.34e-03 GO:0016323 basolateral plasma membrane
1.77 1.11e-02 GO:0015629 actin cytoskeleton
2.29 1.63e-02 GO:0030055 cell-substrate junction
1.99 1.65e-02 GO:0030135 coated vesicle
1.96 2.53e-02 GO:0031252 cell leading edge
2.09 2.85e-02 GO:0030136 clathrin-coated vesicle
1.09 3.45e-02 GO:0005737 cytoplasm

Nothing significant found in function category.