Motif ID: AAUCUCA

Z-value: 0.596


Mature miRNA associated with seed AAUCUCA:

NamemiRBase Accession
hsa-miR-216a-5p MIMAT0000273



Activity profile for motif AAUCUCA.

activity profile for motif AAUCUCA


Sorted Z-values histogram for motif AAUCUCA

Sorted Z-values for motif AAUCUCA



Network of associatons between targets according to the STRING database.



First level regulatory network of AAUCUCA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_53342311 1.083 ENST00000226067.5
 HLF
hepatic leukemia factor
chr7_-_139876812 0.634 ENST00000397560.2
 JHDM1D
lysine (K)-specific demethylase 7A
chrX_+_23352133 0.626 ENST00000379361.4
 PTCHD1
patched domain containing 1
chr6_+_42749759 0.481 ENST00000314073.5
 GLTSCR1L
GLTSCR1-like
chrX_-_20284958 0.468 ENST00000379565.3
 RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr17_-_73975444 0.377 ENST00000293217.5
ENST00000537812.1
 ACOX1

acyl-CoA oxidase 1, palmitoyl

chr1_-_67519782 0.321 ENST00000235345.5
 SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr2_-_242212227 0.307 ENST00000427007.1
ENST00000458564.1
ENST00000452065.1
ENST00000427183.2
ENST00000426343.1
ENST00000422080.1
ENST00000449504.1
ENST00000449864.1
ENST00000391975.1
 HDLBP








high density lipoprotein binding protein








chr11_-_32452357 0.298 ENST00000379079.2
ENST00000530998.1
 WT1

Wilms tumor 1

chr4_-_105416039 0.295 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr11_+_111945011 0.239 ENST00000532163.1
ENST00000280352.9
ENST00000530104.1
ENST00000526879.1
ENST00000393047.3
ENST00000525785.1
 C11orf57





chromosome 11 open reading frame 57





chr18_+_59992527 0.228 ENST00000586569.1
 TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr17_+_64298944 0.224 ENST00000413366.3
 PRKCA
protein kinase C, alpha
chr20_-_524455 0.189 ENST00000349736.5
ENST00000217244.3
 CSNK2A1

casein kinase 2, alpha 1 polypeptide

chr12_-_57030115 0.178 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
 BAZ2A


bromodomain adjacent to zinc finger domain, 2A


chr15_+_40733387 0.158 ENST00000416165.1
 BAHD1
bromo adjacent homology domain containing 1
chr1_-_67896095 0.143 ENST00000370994.4
 SERBP1
SERPINE1 mRNA binding protein 1
chr9_-_20622478 0.136 ENST00000355930.6
ENST00000380338.4
 MLLT3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr1_+_63788730 0.120 ENST00000371116.2
 FOXD3
forkhead box D3
chrX_+_122993827 0.119 ENST00000371199.3
 XIAP
X-linked inhibitor of apoptosis
chr4_+_3076388 0.117 ENST00000355072.5
 HTT
huntingtin
chr4_+_99916765 0.102 ENST00000296411.6
 METAP1
methionyl aminopeptidase 1
chr5_+_149109825 0.088 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
 PPARGC1B


peroxisome proliferator-activated receptor gamma, coactivator 1 beta


chr2_-_172967621 0.087 ENST00000234198.4
ENST00000466293.2
 DLX2

distal-less homeobox 2

chr12_+_50344516 0.082 ENST00000199280.3
ENST00000550862.1
 AQP2

aquaporin 2 (collecting duct)

chr4_-_113437328 0.078 ENST00000313341.3
 NEUROG2
neurogenin 2
chr5_-_178054105 0.064 ENST00000316308.4
 CLK4
CDC-like kinase 4
chr17_+_14204389 0.053 ENST00000360954.2
 HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr13_-_45915221 0.048 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
 TPT1




tumor protein, translationally-controlled 1




chr13_-_31038370 0.011 ENST00000399489.1
ENST00000339872.4
 HMGB1

high mobility group box 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.2 GO:0071848 regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) TNFSF11-mediated signaling pathway(GO:0071847) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.1 0.3 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 0.3 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0019805 lactate metabolic process(GO:0006089) quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0071280 cellular response to copper ion(GO:0071280) cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038) fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:0048892 sensory system development(GO:0048880) lateral line nerve development(GO:0048892) lateral line nerve glial cell differentiation(GO:0048895) lateral line system development(GO:0048925) lateral line nerve glial cell development(GO:0048937) iridophore differentiation(GO:0050935)
0.0 0.1 GO:0007379 segment specification(GO:0007379)
0.0 0.6 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.2 GO:0070822 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 0.4 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.