Motif ID: BBX

Z-value: 0.874


Transcription factors associated with BBX:

Gene SymbolEntrez IDGene Name
BBX ENSG00000114439.14 BBX



Activity profile for motif BBX.

activity profile for motif BBX


Sorted Z-values histogram for motif BBX

Sorted Z-values for motif BBX



Network of associatons between targets according to the STRING database.



First level regulatory network of BBX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_155484155 2.341 ENST00000509493.1
 FGB
fibrinogen beta chain
chr9_-_116837249 2.109 ENST00000466610.2
 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_155484103 1.795 ENST00000302068.4
 FGB
fibrinogen beta chain
chr4_-_70080449 1.499 ENST00000446444.1
 UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr9_-_5833027 1.171 ENST00000339450.5
 ERMP1
endoplasmic reticulum metallopeptidase 1
chr4_-_186697044 0.958 ENST00000437304.2
 SORBS2
sorbin and SH3 domain containing 2
chr6_+_31895254 0.945 ENST00000299367.5
ENST00000442278.2
 C2

complement component 2

chr11_+_22689648 0.933 ENST00000278187.3
 GAS2
growth arrest-specific 2
chr4_-_186733363 0.881 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
 SORBS2


sorbin and SH3 domain containing 2


chr4_-_186696425 0.751 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2


sorbin and SH3 domain containing 2


chr12_-_52887034 0.718 ENST00000330722.6
 KRT6A
keratin 6A
chr22_+_44319619 0.647 ENST00000216180.3
 PNPLA3
patatin-like phospholipase domain containing 3
chr16_+_56672571 0.608 ENST00000290705.8
 MT1A
metallothionein 1A
chr13_+_50570019 0.597 ENST00000442421.1
 TRIM13
tripartite motif containing 13
chr1_-_59043166 0.366 ENST00000371225.2
 TACSTD2
tumor-associated calcium signal transducer 2
chr14_+_23235886 0.366 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
 OXA1L



oxidase (cytochrome c) assembly 1-like



chr1_+_229440129 0.350 ENST00000366688.3
 SPHAR
S-phase response (cyclin related)
chr16_+_28763108 0.342 ENST00000357796.3
ENST00000550983.1
 NPIPB9

nuclear pore complex interacting protein family, member B9

chr5_-_78809950 0.320 ENST00000334082.6
 HOMER1
homer homolog 1 (Drosophila)
chr1_+_55464600 0.304 ENST00000371265.4
 BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr2_+_101437487 0.297 ENST00000427413.1
ENST00000542504.1
 NPAS2

neuronal PAS domain protein 2

chr17_+_66255310 0.273 ENST00000448504.2
 ARSG
arylsulfatase G
chr20_-_30310656 0.263 ENST00000376055.4
 BCL2L1
BCL2-like 1
chr16_-_28374829 0.260 ENST00000532254.1
 NPIPB6
nuclear pore complex interacting protein family, member B6
chr5_+_140514782 0.255 ENST00000231134.5
 PCDHB5
protocadherin beta 5
chr20_-_56286479 0.238 ENST00000265626.4
 PMEPA1
prostate transmembrane protein, androgen induced 1
chr5_+_140480083 0.236 ENST00000231130.2
 PCDHB3
protocadherin beta 3
chrX_+_54834004 0.236 ENST00000375068.1
 MAGED2
melanoma antigen family D, 2
chr9_+_35161998 0.228 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
 UNC13B


unc-13 homolog B (C. elegans)


chr14_+_94492674 0.200 ENST00000203664.5
ENST00000553723.1
 OTUB2

OTU domain, ubiquitin aldehyde binding 2

chr6_-_25874440 0.194 ENST00000361703.6
ENST00000397060.4
 SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr7_-_16872932 0.193 ENST00000419572.2
ENST00000412973.1
 AGR2

anterior gradient 2

chr20_-_30310693 0.190 ENST00000307677.4
ENST00000420653.1
 BCL2L1

BCL2-like 1

chr19_+_47421933 0.186 ENST00000404338.3
 ARHGAP35
Rho GTPase activating protein 35
chr18_-_21017817 0.176 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241





transmembrane protein 241





chr2_-_62081254 0.167 ENST00000405894.3
 FAM161A
family with sequence similarity 161, member A
chr20_-_30310336 0.164 ENST00000434194.1
ENST00000376062.2
 BCL2L1

BCL2-like 1

chr2_-_62081148 0.152 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A
chr1_-_36948879 0.139 ENST00000373106.1
ENST00000373104.1
ENST00000373103.1
 CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr1_+_117963209 0.138 ENST00000449370.2
 MAN1A2
mannosidase, alpha, class 1A, member 2
chr4_+_69313145 0.135 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr6_-_150067696 0.130 ENST00000340413.2
ENST00000367403.3
 NUP43

nucleoporin 43kDa

chr15_+_65823092 0.125 ENST00000566074.1
 PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr6_+_72922590 0.119 ENST00000523963.1
 RIMS1
regulating synaptic membrane exocytosis 1
chr10_-_94003003 0.115 ENST00000412050.4
 CPEB3
cytoplasmic polyadenylation element binding protein 3
chr22_+_32871224 0.114 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
 FBXO7


F-box protein 7


chr11_+_118443098 0.113 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
 ARCN1



archain 1



chr6_+_72922505 0.108 ENST00000401910.3
 RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_10978957 0.097 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr13_+_33160553 0.095 ENST00000315596.10
 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr3_+_148583043 0.091 ENST00000296046.3
 CPA3
carboxypeptidase A3 (mast cell)
chr13_+_28494130 0.083 ENST00000381033.4
 PDX1
pancreatic and duodenal homeobox 1
chr8_-_6783588 0.073 ENST00000297436.2
 DEFA6
defensin, alpha 6, Paneth cell-specific
chr2_-_55237484 0.072 ENST00000394609.2
 RTN4
reticulon 4
chr1_+_52082751 0.069 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
 OSBPL9



oxysterol binding protein-like 9



chr1_-_216978709 0.055 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chrX_-_140786896 0.038 ENST00000370515.3
 SPANXD
SPANX family, member D
chr12_-_21487829 0.029 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
 SLCO1A2




solute carrier organic anion transporter family, member 1A2




chrX_+_140677562 0.025 ENST00000370518.3
 SPANXA2
SPANX family, member A2
chr17_-_8263538 0.023 ENST00000535173.1
 AC135178.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr14_+_22337014 0.022 ENST00000390436.2
 TRAV13-1
T cell receptor alpha variable 13-1
chr11_+_58390132 0.021 ENST00000361987.4
 CNTF
ciliary neurotrophic factor
chr19_+_7828035 0.016 ENST00000327325.5
ENST00000394122.2
ENST00000248228.4
ENST00000334806.5
ENST00000359059.5
ENST00000357361.2
ENST00000596363.1
ENST00000595751.1
ENST00000596707.1
ENST00000597522.1
ENST00000595496.1
 CLEC4M










C-type lectin domain family 4, member M










chr3_+_111260856 0.012 ENST00000352690.4
 CD96
CD96 molecule
chr17_+_45331184 0.007 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
 ITGB3


integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.4 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 0.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.6 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.1 1.5 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 4.1 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0070254 mucus secretion(GO:0070254)
0.0 0.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.7 GO:0007398 ectoderm development(GO:0007398)
0.0 0.6 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503) protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.0 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.9 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 0.9 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 3.6 GO:0005792 obsolete microsome(GO:0005792)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0019862 IgA binding(GO:0019862)
0.2 4.1 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.2 0.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 2.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0046870 cadmium ion binding(GO:0046870)
0.0 1.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.6 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.