Motif ID: HOXA2_HOXB1

Z-value: 1.312

Transcription factors associated with HOXA2_HOXB1:

Gene SymbolEntrez IDGene Name
HOXA2 ENSG00000105996.5 HOXA2
HOXB1 ENSG00000120094.6 HOXB1



Activity profile for motif HOXA2_HOXB1.

activity profile for motif HOXA2_HOXB1


Sorted Z-values histogram for motif HOXA2_HOXB1

Sorted Z-values for motif HOXA2_HOXB1



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_190044480 4.102 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr6_+_151561085 3.262 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr6_+_151561506 3.241 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chrX_-_10645773 2.373 ENST00000453318.2
 MID1
midline 1 (Opitz/BBB syndrome)
chr17_-_46623441 2.293 ENST00000330070.4
 HOXB2
homeobox B2
chrX_-_13835147 2.073 ENST00000493677.1
ENST00000355135.2
 GPM6B

glycoprotein M6B

chr13_-_110438914 1.970 ENST00000375856.3
 IRS2
insulin receptor substrate 2
chr4_-_90757364 1.839 ENST00000508895.1
 SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr11_-_111782696 1.404 ENST00000227251.3
ENST00000526180.1
 CRYAB

crystallin, alpha B

chr4_-_90756769 1.355 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
 SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chrX_-_13835461 0.988 ENST00000316715.4
ENST00000356942.5
 GPM6B

glycoprotein M6B

chr16_-_49890016 0.966 ENST00000563137.2
 ZNF423
zinc finger protein 423
chr7_+_79765071 0.896 ENST00000457358.2
 GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr2_+_12857043 0.890 ENST00000381465.2
 TRIB2
tribbles pseudokinase 2
chr17_+_48609903 0.887 ENST00000268933.3
 EPN3
epsin 3
chr5_-_125930929 0.885 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
 ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr11_-_111782484 0.881 ENST00000533971.1
 CRYAB
crystallin, alpha B
chr2_+_12857015 0.799 ENST00000155926.4
 TRIB2
tribbles pseudokinase 2
chr4_-_102267953 0.758 ENST00000523694.2
ENST00000507176.1
 PPP3CA

protein phosphatase 3, catalytic subunit, alpha isozyme

chr7_-_27135591 0.752 ENST00000343060.4
ENST00000355633.5
 HOXA1

homeobox A1

chr1_-_43833628 0.656 ENST00000413844.2
ENST00000372458.3
 ELOVL1

ELOVL fatty acid elongase 1

chr12_-_28124903 0.632 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
 PTHLH


parathyroid hormone-like hormone


chr12_-_15038779 0.621 ENST00000228938.5
ENST00000539261.1
 MGP

matrix Gla protein

chr16_+_15596123 0.614 ENST00000452191.2
 C16orf45
chromosome 16 open reading frame 45
chr4_-_5021164 0.581 ENST00000506508.1
ENST00000509419.1
ENST00000307746.4
 CYTL1


cytokine-like 1


chr2_+_68961905 0.572 ENST00000295381.3
 ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961934 0.540 ENST00000409202.3
 ARHGAP25
Rho GTPase activating protein 25
chr11_-_122930121 0.534 ENST00000524552.1
 HSPA8
heat shock 70kDa protein 8
chr17_-_42277203 0.528 ENST00000587097.1
 ATXN7L3
ataxin 7-like 3
chrX_+_99899180 0.499 ENST00000373004.3
 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_124320156 0.491 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
 DMBT1





deleted in malignant brain tumors 1





chr10_+_124320195 0.475 ENST00000359586.6
 DMBT1
deleted in malignant brain tumors 1
chr6_-_159065741 0.454 ENST00000367085.3
ENST00000367089.3
 DYNLT1

dynein, light chain, Tctex-type 1

chr7_-_27170352 0.441 ENST00000428284.2
ENST00000360046.5
 HOXA4

homeobox A4

chr10_-_79397316 0.420 ENST00000372421.5
ENST00000457953.1
 KCNMA1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

chr10_-_79397202 0.407 ENST00000372437.1
ENST00000372408.2
ENST00000372403.4
 KCNMA1


potassium large conductance calcium-activated channel, subfamily M, alpha member 1


chr1_+_178062855 0.407 ENST00000448150.3
 RASAL2
RAS protein activator like 2
chr6_-_112575912 0.399 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
 LAMA4


laminin, alpha 4


chr19_+_13051206 0.389 ENST00000586760.1
 CALR
calreticulin
chr6_-_112575687 0.382 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
 LAMA4


laminin, alpha 4


chr10_-_79397479 0.380 ENST00000404771.3
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr8_+_23386557 0.367 ENST00000523930.1
 SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr11_-_122929699 0.366 ENST00000526686.1
 HSPA8
heat shock 70kDa protein 8
chr19_-_51512804 0.363 ENST00000594211.1
ENST00000376832.4
 KLK9

kallikrein-related peptidase 9

chr1_-_217804377 0.343 ENST00000366935.3
ENST00000366934.3
 GPATCH2

G patch domain containing 2

chr2_+_242089833 0.329 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
 PPP1R7



protein phosphatase 1, regulatory subunit 7



chr17_+_39975544 0.318 ENST00000544340.1
 FKBP10
FK506 binding protein 10, 65 kDa
chr1_+_68150744 0.307 ENST00000370986.4
ENST00000370985.3
 GADD45A

growth arrest and DNA-damage-inducible, alpha

chr17_+_39975455 0.300 ENST00000455106.1
 FKBP10
FK506 binding protein 10, 65 kDa
chr2_-_145278475 0.293 ENST00000558170.2
 ZEB2
zinc finger E-box binding homeobox 2
chr1_-_109584768 0.279 ENST00000357672.3
 WDR47
WD repeat domain 47
chr1_-_109584608 0.271 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
 WDR47



WD repeat domain 47



chr1_-_109584716 0.271 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
 WDR47


WD repeat domain 47


chr6_-_112575838 0.264 ENST00000455073.1
 LAMA4
laminin, alpha 4
chr17_-_37353950 0.223 ENST00000394310.3
ENST00000394303.3
ENST00000344140.5
 CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr10_+_95848824 0.206 ENST00000371385.3
ENST00000371375.1
 PLCE1

phospholipase C, epsilon 1

chr18_-_53070913 0.205 ENST00000568186.1
ENST00000564228.1
 TCF4

transcription factor 4

chr9_+_140135665 0.188 ENST00000340384.4
 TUBB4B
tubulin, beta 4B class IVb
chr19_-_12997995 0.184 ENST00000264834.4
 KLF1
Kruppel-like factor 1 (erythroid)
chr2_-_45236540 0.182 ENST00000303077.6
 SIX2
SIX homeobox 2
chr6_-_112575758 0.167 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
 LAMA4



laminin, alpha 4



chr3_+_189507432 0.165 ENST00000354600.5
 TP63
tumor protein p63
chr7_-_14029283 0.160 ENST00000433547.1
ENST00000405192.2
 ETV1

ets variant 1

chr9_-_73029540 0.153 ENST00000377126.2
 KLF9
Kruppel-like factor 9
chr1_-_67390474 0.149 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
 WDR78



WD repeat domain 78



chr2_+_68962014 0.145 ENST00000467265.1
 ARHGAP25
Rho GTPase activating protein 25
chr8_+_23386305 0.134 ENST00000519973.1
 SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr8_-_38008783 0.131 ENST00000276449.4
 STAR
steroidogenic acute regulatory protein
chr12_-_28125638 0.130 ENST00000545234.1
 PTHLH
parathyroid hormone-like hormone
chr1_-_217250231 0.127 ENST00000493748.1
ENST00000463665.1
 ESRRG

estrogen-related receptor gamma

chr10_+_18689637 0.124 ENST00000377315.4
 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr2_-_44588679 0.124 ENST00000409411.1
 PREPL
prolyl endopeptidase-like
chr10_+_89264625 0.121 ENST00000371996.4
ENST00000371994.4
 MINPP1

multiple inositol-polyphosphate phosphatase 1

chr14_+_22985251 0.120 ENST00000390510.1
 TRAJ27
T cell receptor alpha joining 27
chr12_+_21679220 0.119 ENST00000256969.2
 C12orf39
chromosome 12 open reading frame 39
chr2_-_44588694 0.111 ENST00000409957.1
 PREPL
prolyl endopeptidase-like
chr17_+_58755184 0.110 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
 BCAS3


breast carcinoma amplified sequence 3


chr6_+_32006042 0.090 ENST00000418967.2
 CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr7_-_14029515 0.085 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
 ETV1


ets variant 1


chr5_-_10761206 0.079 ENST00000432074.2
ENST00000230895.6
 DAP

death-associated protein

chr12_-_57472522 0.079 ENST00000379391.3
ENST00000300128.4
 TMEM194A

transmembrane protein 194A

chr12_-_114843889 0.078 ENST00000405440.2
 TBX5
T-box 5
chr12_-_58135903 0.075 ENST00000257897.3
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr12_-_86650045 0.067 ENST00000604798.1
 MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_+_29426230 0.062 ENST00000442615.1
 OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr2_+_135011731 0.061 ENST00000281923.2
 MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr12_+_57482877 0.060 ENST00000342556.6
ENST00000357680.4
 NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2)

chr12_-_86650077 0.053 ENST00000552808.2
ENST00000547225.1
 MGAT4C

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

chr6_+_32006159 0.052 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
 CYP21A2


cytochrome P450, family 21, subfamily A, polypeptide 2


chrX_+_48455866 0.046 ENST00000376729.5
ENST00000218056.5
 WDR13

WD repeat domain 13

chr13_-_36050819 0.045 ENST00000379919.4
 MAB21L1
mab-21-like 1 (C. elegans)
chr2_-_49381646 0.042 ENST00000346173.3
ENST00000406846.2
 FSHR

follicle stimulating hormone receptor

chr17_+_37824700 0.037 ENST00000581428.1
 PNMT
phenylethanolamine N-methyltransferase
chr17_-_42276574 0.032 ENST00000589805.1
 ATXN7L3
ataxin 7-like 3
chr8_-_143999259 0.030 ENST00000323110.2
 CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chrX_-_65253506 0.029 ENST00000427538.1
 VSIG4
V-set and immunoglobulin domain containing 4
chr19_+_47421933 0.029 ENST00000404338.3
 ARHGAP35
Rho GTPase activating protein 35
chr2_-_49381572 0.023 ENST00000454032.1
ENST00000304421.4
 FSHR

follicle stimulating hormone receptor

chr7_-_27142290 0.016 ENST00000222718.5
 HOXA2
homeobox A2
chr2_-_200323414 0.011 ENST00000443023.1
 SATB2
SATB homeobox 2
chrX_+_95939711 0.009 ENST00000373049.4
ENST00000324765.8
 DIAPH2

diaphanous-related formin 2

chr1_-_223536679 0.006 ENST00000608996.1
 SUSD4
sushi domain containing 4
chr2_-_200322723 0.004 ENST00000417098.1
 SATB2
SATB homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0021570 rhombomere 4 development(GO:0021570)
0.7 6.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.6 3.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 1.7 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.3 2.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.3 1.0 GO:0019731 antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731)
0.2 0.7 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.2 0.8 GO:0060649 nipple development(GO:0060618) mammary gland bud elongation(GO:0060649) nipple morphogenesis(GO:0060658) nipple sheath formation(GO:0060659)
0.2 1.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) negative regulation of cell volume(GO:0045794)
0.2 4.1 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.9 GO:0006553 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.1 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.1 2.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.5 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.4 GO:0048387 protein maturation by protein folding(GO:0022417) negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 1.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.6 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 2.3 GO:0032387 negative regulation of intracellular transport(GO:0032387)
0.0 0.6 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0061117 cardiac left ventricle formation(GO:0003218) negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.6 GO:0018208 peptidyl-proline modification(GO:0018208)
0.0 0.2 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.9 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.3 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 0.3 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.9 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.3 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 0.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.2 3.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.6 GO:0000124 SAGA complex(GO:0000124)
0.1 1.0 GO:0042589 phagocytic vesicle membrane(GO:0030670) zymogen granule membrane(GO:0042589)
0.1 1.2 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.9 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 6.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0019718 obsolete rough microsome(GO:0019718)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.6 3.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.2 1.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 1.7 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.7 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 1.0 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.1 2.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 5.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway