Motif ID: LHX2

Z-value: 0.480


Transcription factors associated with LHX2:

Gene SymbolEntrez IDGene Name
LHX2 ENSG00000106689.6 LHX2



Activity profile for motif LHX2.

activity profile for motif LHX2


Sorted Z-values histogram for motif LHX2

Sorted Z-values for motif LHX2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_29027696 1.139 ENST00000257189.4
 DSG3
desmoglein 3
chr13_-_99959641 1.033 ENST00000376414.4
 GPR183
G protein-coupled receptor 183
chr12_+_6309517 0.690 ENST00000382519.4
ENST00000009180.4
 CD9

CD9 molecule

chr11_-_104972158 0.672 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
 CASP1



CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase



caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr14_-_106926724 0.613 ENST00000434710.1
 IGHV3-43
immunoglobulin heavy variable 3-43
chr2_-_89157161 0.600 ENST00000390237.2
 IGKC
immunoglobulin kappa constant
chr1_+_160709055 0.576 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
 SLAMF7



SLAM family member 7



chr12_+_6554021 0.517 ENST00000266557.3
 CD27
CD27 molecule
chr1_+_160709029 0.510 ENST00000444090.2
ENST00000441662.2
 SLAMF7

SLAM family member 7

chr13_-_99910673 0.391 ENST00000397473.2
ENST00000397470.2
 GPR18

G protein-coupled receptor 18

chr4_-_90756769 0.380 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
 SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr1_-_183560011 0.344 ENST00000367536.1
 NCF2
neutrophil cytosolic factor 2
chr2_+_234627424 0.344 ENST00000373409.3
 UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr4_-_153332886 0.290 ENST00000603841.1
 FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_-_105416039 0.269 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr2_-_231084617 0.260 ENST00000409815.2
 SP110
SP110 nuclear body protein
chr6_+_30848557 0.246 ENST00000460944.2
ENST00000324771.8
 DDR1

discoidin domain receptor tyrosine kinase 1

chr2_+_68961905 0.244 ENST00000295381.3
 ARHGAP25
Rho GTPase activating protein 25
chr18_+_34124507 0.241 ENST00000591635.1
 FHOD3
formin homology 2 domain containing 3
chr2_+_68961934 0.240 ENST00000409202.3
 ARHGAP25
Rho GTPase activating protein 25
chr7_-_5998714 0.233 ENST00000539903.1
 RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr11_-_104827425 0.229 ENST00000393150.3
 CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_+_125524785 0.223 ENST00000392482.2
 TPD52L1
tumor protein D52-like 1
chr13_+_73632897 0.210 ENST00000377687.4
 KLF5
Kruppel-like factor 5 (intestinal)
chr2_-_231084659 0.204 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
 SP110



SP110 nuclear body protein



chr15_-_72563585 0.192 ENST00000287196.9
ENST00000260376.7
 PARP6

poly (ADP-ribose) polymerase family, member 6

chr10_-_14372870 0.183 ENST00000357447.2
 FRMD4A
FERM domain containing 4A
chr16_+_31271274 0.180 ENST00000287497.8
ENST00000544665.3
 ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr4_-_120243545 0.172 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr2_-_10587897 0.171 ENST00000405333.1
ENST00000443218.1
 ODC1

ornithine decarboxylase 1

chr12_-_118797475 0.152 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3


TAO kinase 3


chr11_+_64001962 0.144 ENST00000309422.2
 VEGFB
vascular endothelial growth factor B
chr18_+_3247779 0.140 ENST00000578611.1
ENST00000583449.1
 MYL12A

myosin, light chain 12A, regulatory, non-sarcomeric

chr21_+_34619079 0.130 ENST00000433395.2
 AP000295.9
AP000295.9
chr9_+_116207007 0.129 ENST00000374140.2
 RGS3
regulator of G-protein signaling 3
chr4_+_69313145 0.123 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr14_+_69865401 0.117 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
 SLC39A9


solute carrier family 39, member 9


chr8_-_109260897 0.115 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
 EIF3E





eukaryotic translation initiation factor 3, subunit E





chr10_+_96443204 0.113 ENST00000339022.5
 CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
chr7_-_54826920 0.112 ENST00000395535.3
ENST00000352861.4
 SEC61G

Sec61 gamma subunit

chr12_-_11548496 0.106 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
 PRB2

PRB1
proline-rich protein BstNI subfamily 2

proline-rich protein BstNI subfamily 1
chr5_+_179921344 0.103 ENST00000261951.4
 CNOT6
CCR4-NOT transcription complex, subunit 6
chr17_-_38859996 0.097 ENST00000264651.2
 KRT24
keratin 24
chr12_+_16064106 0.096 ENST00000428559.2
 DERA
deoxyribose-phosphate aldolase (putative)
chr1_-_147142557 0.096 ENST00000369238.6
 ACP6
acid phosphatase 6, lysophosphatidic
chr14_-_51027838 0.082 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr7_-_103848405 0.081 ENST00000447452.2
ENST00000545943.1
ENST00000297431.4
 ORC5


origin recognition complex, subunit 5


chr3_+_108541545 0.076 ENST00000295756.6
 TRAT1
T cell receptor associated transmembrane adaptor 1
chr7_-_54826869 0.074 ENST00000450622.1
 SEC61G
Sec61 gamma subunit
chr2_+_90139056 0.073 ENST00000492446.1
 IGKV1D-16
immunoglobulin kappa variable 1D-16
chr11_+_31391381 0.072 ENST00000465995.1
ENST00000536040.1
 DNAJC24

DnaJ (Hsp40) homolog, subfamily C, member 24

chr11_+_27076764 0.072 ENST00000525090.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_+_64173583 0.071 ENST00000261234.6
 TMEM5
transmembrane protein 5
chr9_-_100854838 0.068 ENST00000538344.1
 TRIM14
tripartite motif containing 14
chr7_-_122840015 0.065 ENST00000194130.2
 SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr2_+_210517895 0.064 ENST00000447185.1
 MAP2
microtubule-associated protein 2
chr17_-_39222131 0.063 ENST00000394015.2
 KRTAP2-4
keratin associated protein 2-4
chr3_+_108541608 0.059 ENST00000426646.1
 TRAT1
T cell receptor associated transmembrane adaptor 1
chr13_+_33160553 0.059 ENST00000315596.10
 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr10_-_61900762 0.055 ENST00000355288.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_-_107211459 0.051 ENST00000390636.2
 IGHV3-73
immunoglobulin heavy variable 3-73
chr9_+_108320392 0.050 ENST00000602661.1
ENST00000223528.2
ENST00000448551.2
ENST00000540160.1
 FKTN



fukutin



chr2_+_145780767 0.049 ENST00000599358.1
ENST00000596278.1
ENST00000596747.1
ENST00000608652.1
ENST00000609705.1
ENST00000608432.1
ENST00000596970.1
ENST00000602041.1
ENST00000601578.1
ENST00000596034.1
ENST00000414195.2
ENST00000594837.1
 TEX41











testis expressed 41 (non-protein coding)











chr15_+_58430567 0.049 ENST00000536493.1
 AQP9
aquaporin 9
chr4_+_88532028 0.048 ENST00000282478.7
 DSPP
dentin sialophosphoprotein
chr15_+_58430368 0.046 ENST00000558772.1
ENST00000219919.4
 AQP9

aquaporin 9

chr18_+_66465302 0.046 ENST00000360242.5
ENST00000358653.5
 CCDC102B

coiled-coil domain containing 102B

chr21_-_35014027 0.044 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
 CRYZL1







crystallin, zeta (quinone reductase)-like 1







chr2_+_45168875 0.040 ENST00000260653.3
 SIX3
SIX homeobox 3
chr6_-_26027480 0.038 ENST00000377364.3
 HIST1H4B
histone cluster 1, H4b
chr16_+_24266874 0.037 ENST00000005284.3
 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_-_89591749 0.037 ENST00000370466.3
 GBP2
guanylate binding protein 2, interferon-inducible
chrX_+_99839799 0.035 ENST00000373031.4
 TNMD
tenomodulin
chr8_+_76452097 0.034 ENST00000396423.2
 HNF4G
hepatocyte nuclear factor 4, gamma
chr9_+_105757590 0.033 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr19_+_22235310 0.033 ENST00000600162.1
 ZNF257
zinc finger protein 257
chr6_+_26199737 0.031 ENST00000359985.1
 HIST1H2BF
histone cluster 1, H2bf
chr19_+_42212526 0.025 ENST00000221992.6
ENST00000405816.1
ENST00000598976.1
ENST00000435837.2
 CEACAM5

CEA

carcinoembryonic antigen-related cell adhesion molecule 5

Uncharacterized protein

chr2_+_145780739 0.024 ENST00000597173.1
ENST00000602108.1
ENST00000420472.1
 TEX41


testis expressed 41 (non-protein coding)


chr12_-_25348007 0.024 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr11_+_24518723 0.024 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
 LUZP2


leucine zipper protein 2


chr12_-_10955226 0.020 ENST00000240687.2
 TAS2R7
taste receptor, type 2, member 7
chr3_-_131221790 0.019 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
 MRPL3



mitochondrial ribosomal protein L3



chr4_+_128554081 0.019 ENST00000335251.6
ENST00000296461.5
 INTU

inturned planar cell polarity protein

chr3_+_119187785 0.018 ENST00000295588.4
ENST00000476573.1
 POGLUT1

protein O-glucosyltransferase 1

chr13_-_19755975 0.018 ENST00000400113.3
 TUBA3C
tubulin, alpha 3c
chr4_+_70796784 0.017 ENST00000246891.4
ENST00000444405.3
 CSN1S1

casein alpha s1

chr7_-_14880892 0.016 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
 DGKB


diacylglycerol kinase, beta 90kDa


chr2_-_208989225 0.016 ENST00000264376.4
 CRYGD
crystallin, gamma D
chr18_-_19994830 0.015 ENST00000525417.1
 CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr14_+_22694606 0.015 ENST00000390463.3
 TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr10_-_90712520 0.014 ENST00000224784.6
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_+_156433573 0.014 ENST00000311822.8
 RNF32
ring finger protein 32
chr2_+_173686303 0.011 ENST00000397087.3
 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr14_+_56078695 0.004 ENST00000416613.1
 KTN1
kinectin 1 (kinesin receptor)
chrX_-_138724677 0.003 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
 MCF2


MCF.2 cell line derived transforming sequence


chr17_+_17082842 0.003 ENST00000579361.1
 MPRIP
myosin phosphatase Rho interacting protein
chr12_+_122688090 0.002 ENST00000324189.4
ENST00000546192.1
 B3GNT4

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4

chr9_+_21440440 0.002 ENST00000276927.1
 IFNA1
interferon, alpha 1
chr12_+_94071129 0.001 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
 CRADD



CASP2 and RIPK1 domain containing adaptor with death domain




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0030913 paranodal junction assembly(GO:0030913)
0.2 1.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.1 0.5 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.0 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.0 0.3 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.1 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.2 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.3 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) bile acid secretion(GO:0032782)
0.0 0.2 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.2 GO:0060749 mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)
0.0 0.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0050798 activated T cell proliferation(GO:0050798)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.1 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.0 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.0 0.9 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.6 GO:0003823 antigen binding(GO:0003823)